Mesoscopic effects in tunneling between parallel quantum wires

We consider a phase-coherent system of two parallel quantum wires that are coupled via a tunneling barrier of finite length. The usual perturbative treatment of tunneling fails in this case, even in the diffusive limit, once the length L of the coupling region exceeds a characteristic length scale L_t set by tunneling. Exact solution of the scattering problem posed by the extended tunneling barrier allows us to compute tunneling conductances as a function of applied voltage and magnetic field. We take into account charging effects in the quantum wires due to applied voltages and find that these are important for 1D-to-1D tunneling transport.Comment: 8 pages, 7 figures, improved Figs., added Refs. and appendix, to appear in Phys. Rev.

The PHENIX Experiment at RHIC

The physics emphases of the PHENIX collaboration and the design and current status of the PHENIX detector are discussed. The plan of the collaboration for making the most effective use of the available luminosity in the first years of RHIC operation is also presented.Comment: 5 pages, 1 figure. Further details of the PHENIX physics program available at http://www.rhic.bnl.gov/phenix

Global surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2)

BACKGROUND: Worldwide data for cancer survival are scarce. We aimed to initiate worldwide surveillance of cancer survival by central analysis of population-based registry data, as a metric of the effectiveness of health systems, and to inform global policy on cancer control. METHODS: Individual tumour records were submitted by 279 population-based cancer registries in 67 countries for 25·7 million adults (age 15-99 years) and 75,000 children (age 0-14 years) diagnosed with cancer during 1995-2009 and followed up to Dec 31, 2009, or later. We looked at cancers of the stomach, colon, rectum, liver, lung, breast (women), cervix, ovary, and prostate in adults, and adult and childhood leukaemia. Standardised quality control procedures were applied; errors were corrected by the registry concerned. We estimated 5-year net survival, adjusted for background mortality in every country or region by age (single year), sex, and calendar year, and by race or ethnic origin in some countries. Estimates were age-standardised with the International Cancer Survival Standard weights. FINDINGS: 5-year survival from colon, rectal, and breast cancers has increased steadily in most developed countries. For patients diagnosed during 2005-09, survival for colon and rectal cancer reached 60% or more in 22 countries around the world; for breast cancer, 5-year survival rose to 85% or higher in 17 countries worldwide. Liver and lung cancer remain lethal in all nations: for both cancers, 5-year survival is below 20% everywhere in Europe, in the range 15-19% in North America, and as low as 7-9% in Mongolia and Thailand. Striking rises in 5-year survival from prostate cancer have occurred in many countries: survival rose by 10-20% between 1995-99 and 2005-09 in 22 countries in South America, Asia, and Europe, but survival still varies widely around the world, from less than 60% in Bulgaria and Thailand to 95% or more in Brazil, Puerto Rico, and the USA. For cervical cancer, national estimates of 5-year survival range from less than 50% to more than 70%; regional variations are much wider, and improvements between 1995-99 and 2005-09 have generally been slight. For women diagnosed with ovarian cancer in 2005-09, 5-year survival was 40% or higher only in Ecuador, the USA, and 17 countries in Asia and Europe. 5-year survival for stomach cancer in 2005-09 was high (54-58%) in Japan and South Korea, compared with less than 40% in other countries. By contrast, 5-year survival from adult leukaemia in Japan and South Korea (18-23%) is lower than in most other countries. 5-year survival from childhood acute lymphoblastic leukaemia is less than 60% in several countries, but as high as 90% in Canada and four European countries, which suggests major deficiencies in the management of a largely curable disease. INTERPRETATION: International comparison of survival trends reveals very wide differences that are likely to be attributable to differences in access to early diagnosis and optimum treatment. Continuous worldwide surveillance of cancer survival should become an indispensable source of information for cancer patients and researchers and a stimulus for politicians to improve health policy and health-care systems

T-cell receptor excision circle levels and safety of paediatric immunization: A population-based self-controlled case series analysis

T-cell receptor excision circle levels are a surrogate marker of T-cell production and immune system function. We sought to determine whether non-pathological levels of infant T-cell receptor excision circles were associated with adverse events following immunization. A self-controlled case series design was applied on a sample of 231,693 children who completed newborn screening for severe combined immunodeficiency in Ontario, Canada between August 2013 and December 2015. Exposures included routinely administered pediatric vaccines up to 15 months of age. Main outcomes were combined health services utilization for recognized adverse events following immunization. 1,406,981 vaccination events were included in the final dataset. 103,007 children received the Pneu-C-13 or Men-C-C vaccine and 97,998 received the MMR vaccine at 12 months of age. 67,725 children received the varicella immunization at 15 months. Our analysis identified no association between newborn T-cell receptor excision circle levels and subsequent health services utilization events following DTa-IPV-Hib, Pneu-C-13, and Men-C-C vaccinations at 2-month (RI 0.94[95%CI 0.87-1.02]), 4-month (RI 0.82[95%CI 0.75-0.9]), 6-month (RI 0.63[95%CI 0.57-0.7]) and 12-month (RI 0.49[95%CI 0.44-0.55]). We also found no trends in health services utilization following MMR (RI 1.43[95%1.34-1.52]) or varicella (RI 1.14[95%CI 1.05-1.23]) vaccination. Our findings provide further support for the safety of pediatric vaccinations

Quantum theory of bilayer quantum Hall smectics

Mean-field theory predicts that bilayer quantum Hall systems at odd integer total filling factors can have stripe ground states, in which the top Landau level is occupied alternately by electrons in one of the two layers. We report on an analysis of the properties of these states based on a coupled-Luttinger-liquid description that is able to account for quantum fluctuations of charge-density and position along each stripe edge. The soft modes associated with the broken symmetries of the stripe state lead to an unusual coupled-Luttinger-liquid system with strongly enhanced low-temperature heat capacity and strongly suppressed low-energy tunneling density of states. We assess the importance of the intralayer and interlayer backscattering terms in the microscopic Hamiltonian, which are absent in the Luttinger liquid description, by employing a perturbative renormalization group approach which rescales time and length along but not transverse to the stripes. With interlayer backscattering interactions present the Luttinger-liquid states are unstable either to an incompressible striped state that has spontaneous interlayer phase coherence and a sizable charge gap even at relatively large layer separations, or to Wigner crystal states. Our quantitative estimates of the gaps produced by backscattering interactions are summarized in Fig. 11 by a schematic phase diagram intended to represent predicted experimental findings in very high mobility bilayer systems at dilution refrigerator temperatures as a function of layer separation and bilayer density balance. We predict that the bilayer will form incompressible isotropic interlayer phase-coherent states for small layer separations, say d<~1.5l. At larger interlayer spacings, however, the bilayer will tend to form one of several different anisotropic states depending on the layer charge balance, which we parametrize by the fractional filling factor ν contributed by one of the two layers. For large charge imbalances (ν far from 1/2), we predict states in which anisotropic Wigner crystals form in each of the layers. For ν closer to 1/2, we predict stripe states that have spontaneous interlayer phase-coherence and a gap for charged excitations. These states should exhibit the quantum Hall effect for current flowing within the layers and also the giant interlayer tunneling conductance anomalies at low bias voltages that have been observed in bilayers when the N=0 Landau level is partially filled. When the gaps produced by backscattering interactions are sufficiently small, the phenomenology observed at typical dilution fridge temperatures will be that of a smectic metal, anisotropic transport without a quantum Hall effect. For stripe states in the N=2 Landau level, this behavior is expected over a range of bilayer charge imbalances on both sides of ν=1/2