Condensation of Hard Spheres Under Gravity

Starting from Enskog equation of hard spheres of mass m and diameter D under the gravity g, we first derive the exact equation of motion for the equilibrium density profile at a temperature T and examine its solutions via the gradient expansion. The solutions exist only when \beta\mu \le \mu_o \approx 21.756 in 2 dimensions and \mu_o\approx 15.299 in 3 dimensions, where \mu is the dimensionless initial layer thickness and \beta=mgD/T. When this inequality breaks down, a fraction of particles condense from the bottom up to the Fermi surface.Comment: 9 pages, one figur

Supporting interoperability of genetic data with LOINC

Electronic reporting of genetic testing results is increasing, but they are often represented in diverse formats and naming conventions. Logical Observation Identifiers Names and Codes (LOINC) is a vocabulary standard that provides universal identifiers for laboratory tests and clinical observations. In genetics, LOINC provides codes to improve interoperability in the midst of reporting style transition, including codes for cytogenetic or mutation analysis tests, specific chromosomal alteration or mutation testing, and fully structured discrete genetic test reporting. LOINC terms follow the recommendations and nomenclature of other standards such as the Human Genome Organization Gene Nomenclature Committee’s terminology for gene names. In addition to the narrative text they report now, we recommend that laboratories always report as discrete variables chromosome analysis results, genetic variation(s) found, and genetic variation(s) tested for. By adopting and implementing data standards like LOINC, information systems can help care providers and researchers unlock the potential of genetic information for delivering more personalized care

Estimating economic and social welfare impacts of pension reform

This paper examines the impact of two effects of the pension reform package that the UK Government put forward in the May White Paper Security in retirement: the likely increase in the number of older people working due to a higher State Pension age and the likely rise in saving due to more people putting away money for retirement. The overall effect of changes to State Pension age and the introduction of personal accounts on UK incomes is likely to be in the range of 0.9 – 3.1 per cent. Although these numbers are relatively small proportions of the total economy, they represent significant sums. In terms of today’s economy, they would be worth around £11 – 38 billion. This paper also applies an innovative economic analysis to examine the scale of the increase in people’s wellbeing as a result of improved consumption smoothing. It finds that if people save for retirement through personal accounts, then generally their wellbeing will be enhanced.pension reform; consumption smoothing; social welfare

Colorectal cancer, liver metastases and biotherapies

(1) Background: colorectal cancer (CRC) is one of the deadliest causes of death by cancer worldwide. Its first main metastatic diffusion spreads to the liver. Different mechanisms such as the epithelial–mesenchymal transition and angiogenesis are the characteristics of this invasion. At this stage, different options are possible and still in debate, especially regarding the use of targeted therapeutics and biotherapies. (2) Methods: A review of the literature has been done focusing on the clinical management of liver metastasis of colorectal cancer and the contribution of biotherapies in this field. (3) Results: In a clinical setting, surgeons and oncologists consider liver metastasis in CRC into two groups to launch adapted therapeutics: resectable and non-resectable. Around these two entities, the combination of targeted therapies and biotherapies are of high interest and are currently tested to know in which molecular and clinical conditions they have to be applied to impact positively both on survival and quality of life of patients

A Galvanic Coupling Method for Assessing Hydration Rates

Recent advances in biomedical sensors, data acquisition techniques, microelectronics and wireless communication systems opened up the use of wearable technology for ehealth monitoring. We introduce a galvanic coupled intrabody communication for monitoring human body hydration. Studies in hydration provide the information necessary for understanding the desired fluid levels for optimal performance of the body’s physiological and metabolic processes during exercise and activities of daily living. Current measurement techniques are mostly suitable for laboratory purposes due to their complexity and technical requirements. Less technical methods such as urine color observation and skin turgor testing are subjective and cannot be integrated into a wearable device. Bioelectrical impedance methods are popular but mostly used for estimating total body water with limited accuracy and sensitive to 800 mL–1000 mL change in body fluid levels. We introduce a non-intrusive and simple method of tracking hydration rates that can detect up to 1.30 dB reduction in attenuation when as little as 100 mL of water is consumed. Our results show that galvanic coupled intrabody signal propagation can provide qualitative hydration and dehydration rates in line with changes in an individual’s urine specific gravity and body mass. The real-time changes in galvanic coupled intrabody signal attenuation can be integrated into wearable electronic devices to evaluate body fluid levels on a particular area of interest and can aid diagnosis and treatment of fluid disorders such as lymphoedema