Applying calcium fluoride and silica particles: A solution to improve color homogeneity of pc-WLEDS

This article focuses on enhancing the lighting efficiency of pc-WLEDs, a new and advanced lighting solution that has received lots of attention. To adapt to the demand of modern lighting, the lighting performance of pc-WLEDs must be improved, especially the color homogeneity and luminous flux, two of the most important quality indicators of pc-WLEDs. Through experiments, this article proposes using the scattering enhancement particles (SEPs) such as CaF2 and SiO2 with yellow phosphor Y3Al5O12:Ce3+ in pc-WLEDs configuration. The pc-WLEDs model is created by using the LightTools program and set at 8500 K correlated color temperature, while the experimental results yielded from this simulation will be verified by Mie-scattering theory. The information from this article reveals the scattering coefficients of SEPs at 455 nm and 595 nm wavelengths. Moreover, it is confirmed that the employment of CaF2 is effective in promoting the color but may damage the luminous efficiency if the concentration is too high while the SEP material, SiO2, exhibits high luminous efficiency at all concentration

CHOOSE REMEMBERSHIP REMEDIES TO IMPROVE THE HAPPINESS OF FEMALE OFFICERS AND OFFICERS UNIVERSITY OF FITNESS AND SPORTS DA NANG, VIETNAM

Happiness has long been a veritable area of scientific research in most industrialized countries. Using the method of synthesis of documents and interview method, the study investigates the current state of happiness of 30 female officers and employees of Danang University of Physical Education and Sports using the author's happiness scale. Michael Argyle and Peter Hills (2002) have shown: 30.0% less are happy; 43.33% are happy on average; 26.67% are moderately happy; the most important factor in happiness is health. Subject-selected measures that can increase happiness are finding moments with loved ones in the family; practising more positive thinking; accepting the reality of the situation; join arts and sports clubs

THE PATENTED DRUGS UTILIZATION: A STUDY AT NGUYEN DINH CHIEU HOSPITAL IN BEN TRE PROVINCE FROM 2011 TO 2017

Objective: With their new and efficacious active ingredients, patented drugs have important roles in offering high-quality healthcare. However, huge cost-related barriers in accessing patented drugs along with the availability of low-cost bioequivalent generics have great impact on drugs policy in Vietnam. To understand situation of patented drugs utilization at hospitals for a certain period, this pilot study was conducted at Nguyen-Dinh-Chieu Hospital in Ben-Tre Province. Methods: The cross-sectional descriptive study was conducted on the retrospective data of all patented drugs used at Nguyen-Dinh-Chieu Hospital in Ben-Tre Province from 2011-2017. Characteristics of drugs utilization were described by frequency and percentage of drugs quantities and costs. Criteria for the description were as follows: active ingredient, route of administration, therapeutic class and manufacturing country. Data were extracted from the hospital information system and were processed by R software. Results: From 2011 to 2017, there were 212 patented drugs used which related to 145 active ingredients and 20 therapeutic classes. 88% were single active ingredient drugs and 49% were oral drugs. Antimicrobial and cardiovascular drugs represented the largest number of drugs and the highest cost. 79% of patented drugs were manufactured by companies in Europe and the majority came from France and Germany. Conclusion: This study provided initial information about the utilization of patented drugs during a long period of time at a Vietnamese hospital. The understanding gained will aid medical managers in assessment and adjustment of the drugs list, thus, optimizing the hospital budget and the equity in access to drugs within communities

The study of convex-dual-layer remote phosphor geometry in upgrading WLEDs color rendering index

The white-light light-emitting diode (LED) is a semiconductor light source that usually has one chip and one phosphor layer. Because of that simple structure, the color rendering index (CRI) is really poor. Therefore, structure with double layer of phosphor and multiple chips has been studied with the phosphorus proportions and densities in the silicone are constantly changed to find the best option to improve optical properties. In research, we use red phosphor Ca5B2SiO10:Eu3+ layer to place above the yellow phosphor one, and both of them have a convex design. Then, the experiments and measurements are carried out to figure out the effects of this red phosphor as well as the convex-double-layer remote phosphor design on the LED’s performances. The measured results reveal that the light output is enhanced significantly when using convex-dual-layer structure instead of the single-layer design. Additionally, the Ca5B2SiO10:Eu3+ concentration benefits CRI and CQS at around 6600 K and 7700 K correlated color temperature (CCT). Yet, the lumen output shows a slight decline as this red phosphor concentration surpass 26% wt. Through the experiments, it is found that a double layer of chip and double phosphorus is the best structure which could support the quality of CRI and luminous flux

FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo

<p>Abstract</p> <p>Background</p> <p>FIZ1 (Flt-3 Interacting Zinc-finger) is a broadly expressed protein of unknown function. We reported previously that in the mammalian retina, FIZ1 interacts with NRL (Neural-Retina Leucine-zipper), an essential transcriptional activator of rod photoreceptor-specific genes. The concentration of FIZ1 in the retina increases during photoreceptor terminal maturation, when two key transcription factors NRL and CRX (Cone-Rod Homeobox) become detectable on the promoters of photoreceptor-specific genes (i.e. <it>Rhodopsin, Pde6b</it>). To determine if FIZ1 is involved in regulating CRX-mediated transcriptional activation, we examined FIZ1 subcellular location in mouse neural retina, its ability to interact with CRX, and its association with CRX/NRL target genes.</p> <p>Results</p> <p>FIZ1 is present in the nucleus of adult photoreceptors as well as other retinal neurons as shown by transmission electron microscopy with nano-gold labeling. FIZ1 and CRX were co-precipitated from retinal nuclear extracts with antibodies to either protein. Chromatin immunoprecipitation (ChIP) assays revealed that FIZ1 is part of the protein complex on several rod and cone gene promoters, within photoreceptor cells of the mouse retina. FIZ1 complexes with CRX or NRL on known NRL- and CRX-responsive elements, as shown by electrophoretic mobility shift assays with FIZ1 antibody. FIZ1 can directly bind to CRX, as demonstrated using yeast two-hybrid and GST pull-down assays. Co-transfection assays demonstrated that FIZ1 increases CRX-mediated activation of <it>Opsin </it>test promoters. Quantitative ChIP analysis revealed an increased association of FIZ1 with the <it>Rhodopsin </it>promoter in adult (P-25) neural retina versus immature (P-3) neural retina. The quantity of transcriptionally active RNA Polymerase-II within the <it>Rhodopsin </it>gene (<it>Rho</it>) was significantly increased in the adult neural retina, compared to the immature retina.</p> <p>Conclusion</p> <p>FIZ1 directly interacts with CRX to enhance CRX's transactivation activity for target genes. Developmentally, in neural retina tissue, the increased association of FIZ1 with CRX target genes corresponds to an increased association of transcriptionally active Pol-II within the <it>Rho </it>gene. Together with previous findings, our results suggest that FIZ1 may act as a transcriptional co-regulator of photoreceptor-specific genes, recruited by at least two photoreceptor-specific transcription factors, CRX and NRL. Further studies are underway to elucidate the exact role of FIZ1 in photoreceptor gene expression, development and maintenance.</p

ELISA Measurement of Specific Non-antigen-bound Antibodies to Ab1-42 Monomer and Soluble Oligomers in Sera from Alzheimer\u27s Disease, Mild Cognitively Impaired, and Noncognitively Impaired Subjects

The article presents a study for enzyme-linked immunosorbent assay (ELISA) measurement of specific non-antigen-bound antibodies to Aβ1-42 monomer and soluble oligomers in Alzheimer\u27s disease (AD), mild cognitively impaired (MCI), and noncognitively impaired (NCI) sera. In the study, serum samples were obtained from the Rush Alzheimer\u27s Disease Center, Chicago, Illinois

Measuring Supply Chain Smart Village Headman Performance

The supply chain management as the general tool can be used for supporting and delivering the goods to the villages. The village head is the leader of the village government. The tenure of the village head is 6 years, and can be extended for another one term is expected to run the government with a good performance in providing services to the community. So with the proper use of the supply chain the needs of the villages can be provide by the government. The Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) method can help decision making in determining the performance index of the village head. This research is conduct by looking for the performance of positive and negative ideal solutions. Applications with the highest V value will occupy the top size in this system. Then the criteria in determining the performance index of the head of the village are: timeliness, discipline, responsibility, leadership, presence, value. The results of the decision-making system resulted in 6 alternative suggested performance indexes of village heads, with the highest score of Sending Agung Village

Measuring Supply Chain Performance through Migrant Workers Placement

To facilitate existing procedures and improve decision making, a decision support system (SPK) needs to be built. This SPK aimed  to determine the placement of workers abroad using the Simple Additive Weighting (SAW) method and supply chain process. This method was chosen because it is  able to select the best alternative from a number of alternatives, in this case the alternative in question was  someone who was entitled to receive Placement based on predetermined criteria. This research was conducted by looking for weight values for each individual. The Decision Support System produced was  capable of ranking prospective Indonesian migrant workers and  making it easier for BP3TKI to make decisions about Indonesian migrant workers by supply chain resource management for who will depart abroad