Организация продажи продуктов питания через интернет

Рассмотрение экономических, управленческих и технических аспектов создания стартапа. Проведение исследования потребительских предпочтений на основе технологии Customer Development. Осуществление подготовки проекта стартапа. Объектом исследования является проект "S-Market" - приложение и веб-страница по продажи продуктов on-line в г. Томск. Предметом исследования является процесс создания старт-ап проекта при выведении нового продукта на рынок. Цель работы – разработка старт-ап плана по выведению нового продукта (приложения и веб-страницу) проекта "S-Market" на томский рынок онлайн-продаж продуктов питания.Consideration of economic, managerial and technical aspects creating a startup. Conducting research consumer preferences based Technology Customer Development. Training startup project. The object of the study is the S-Market project - an application and a web page for selling on-line products in Tomsk. The subject of the study is the process of creating a start-up project when introducing a new product to the market. The purpose of the work is to develop a start-up plan for introducing a new product (application and web page) of the S-Market project to the Tomsk market for online food sales

Use of gaming and simulation‐design technology in the formation of the readiness would‐be teachers of geography for specialized education of senior pupils

 В статті здійснено аналіз використання імітаційноігрових і проектних технологій у процесі професійнопедагогічної підготовки майбутніх учителів географії. Виявлено можливості та з’ясовано вплив означених технологій на процес формування готовності майбутніх учителів географії до профільного навчання старшокласників

Анализ напряженно-деформированного состояния компенсаторов при проектировании нефтепроводов с использованием программного комплекса ANSYS

В работе рассмотрены характеристики исследуемого объекта – термокомпенсационные блоки на участке нефтепровода "Заполярье-Пурпе". Приведен расчет толщины стенки трубопровода, проверка его прочности и устойчивости, расчет компенсатора и его компенсирующей способности. Выполнено моделирование компенсаторов различного типа в программном комплексе Autodesk Inventor. Проведен анализ напряженно-деформированного состояния конструкций в программной среде ANSYS.The paper describes the characteristics of the studied object - thermal compensation blocks on the section of the Zapolyarye-Purpe oil pipeline. The calculation of the wall thickness of the pipeline, the verification of its strength and stability, the calculation of the compensator and its compensating ability. Compensators of various types have been simulated in the Autodesk Inventor software package. The analysis of the stress-strain state of structures in the ANSYS program is carried out

Neuroprotective role of gonadal steroid hormones in a rat stroke model

Stroke is the third leading cause of mortality in the Western civilization and the first listed for severe disability and intensive aftercare. It is classified by the World Health Organisation as a pathological acute brain disease of cerebrovascular origin that can lead to long-lasting neurological impairments or even death. Two major forms of stroke exist, namely embolism of brain arteries and rupture of a brain blood vessel. For embolism, hitherto, lysis of blood clots by tissue plasminogen activator is the only accepted therapeutic option for acute stroke. Many other compounds have been tested in animals and pilot human trials but finally failed to prove effectiveness in human stroke therapy. The gonadal hormones 17ß-estradiol (E) and progesterone (P) are known to be neuroprotective factors in the brain preventing neuronal death or damage under different injury paradigms. The present study demonstrates that both steroids in combination derogate brain damage, improve behavioral function, and regulate decisive cellular/molecular routes of neuroprotective mechanism such as neuroinflammatory responses or induction of growth factor expression after 1 h transient middle cerebral artery occlusion (tMCAO). 51 male and 12 ovariectomized female rats were included in the study and subjected either to single or combined hormone treatment. The survival period was 24 h. Effective doses of steroid hormones were 25 µg/kg body weight E and 10 mg/kg body weight P. The steroid hormones were applied two-times, immediately after tMCAO and 12 h later. The combined application of both gonadal hormones diminished the cerebral cortical infarct volume to a similar extent in both sexes by ~70%. In this context, P was more effective as E, when applied seperately. Evaluation of neurological scoring revealed an equal degree of improved functional motor performance after hormone treatment in both genders. Expression studies in the delineated penumbra indicated that the combined gonadal hormone treatment dampended tMCAO-induced pro-inflammatory mediators such as interleukin 6, and the chemokines CCL2 and CCL5. Equally, the numbers of infiltrated microglial cells, macrophages, and lymphocytes were reduced after hormone application. Beside steroid-dependent anti-inflammatory effects, the expression of vascular endothelial growth factor A was potentiated by steroid hormones. In addition, nuclear factor erythroid 2-related factor 2 (Nrf2), a anti-oxidative transcriptional marker, was activated in the penumbra after stroke as indicated by immunofluorescence staining. Nrf2 was discovered in microglia, astrocytes, and neurons within the penumbra. The evaluation of the putative target genes of Nrf2, NAD(P)H: quinone oxidoreductase (NQO1)and heme oxygenase (decycling) 1 (Hamox1), revealed a tMCAO-induced upregulation of these anti-oxidative enzymes on mRNA. Gonadal hormones significantly intensified NQO1 but not Hamox1 expression. These data clearly indicate the short-term neuroprotective potency of a combined treatment with E and P under ischemic conditions in both genders in a rat model. We assume that the dampening of the early local neuroinflammation and the reduction of oxidative stress are both crucial for this neuroprotective action. Further experimental studies are required to analyze the long-term efficacy of both steroids under ischemic coinditions before translational studies in human patients can be started

Neuroprotective role of gonadal steroid hormones in a rat stroke model

Stroke is the third leading cause of mortality in the Western civilization and the first listed for severe disability and intensive aftercare. It is classified by the World Health Organisation as a pathological acute brain disease of cerebrovascular origin that can lead to long-lasting neurological impairments or even death. Two major forms of stroke exist, namely embolism of brain arteries and rupture of a brain blood vessel. For embolism, hitherto, lysis of blood clots by tissue plasminogen activator is the only accepted therapeutic option for acute stroke. Many other compounds have been tested in animals and pilot human trials but finally failed to prove effectiveness in human stroke therapy. The gonadal hormones 17ß-estradiol (E) and progesterone (P) are known to be neuroprotective factors in the brain preventing neuronal death or damage under different injury paradigms. The present study demonstrates that both steroids in combination derogate brain damage, improve behavioral function, and regulate decisive cellular/molecular routes of neuroprotective mechanism such as neuroinflammatory responses or induction of growth factor expression after 1 h transient middle cerebral artery occlusion (tMCAO). 51 male and 12 ovariectomized female rats were included in the study and subjected either to single or combined hormone treatment. The survival period was 24 h. Effective doses of steroid hormones were 25 µg/kg body weight E and 10 mg/kg body weight P. The steroid hormones were applied two-times, immediately after tMCAO and 12 h later. The combined application of both gonadal hormones diminished the cerebral cortical infarct volume to a similar extent in both sexes by ~70%. In this context, P was more effective as E, when applied seperately. Evaluation of neurological scoring revealed an equal degree of improved functional motor performance after hormone treatment in both genders. Expression studies in the delineated penumbra indicated that the combined gonadal hormone treatment dampended tMCAO-induced pro-inflammatory mediators such as interleukin 6, and the chemokines CCL2 and CCL5. Equally, the numbers of infiltrated microglial cells, macrophages, and lymphocytes were reduced after hormone application. Beside steroid-dependent anti-inflammatory effects, the expression of vascular endothelial growth factor A was potentiated by steroid hormones. In addition, nuclear factor erythroid 2-related factor 2 (Nrf2), a anti-oxidative transcriptional marker, was activated in the penumbra after stroke as indicated by immunofluorescence staining. Nrf2 was discovered in microglia, astrocytes, and neurons within the penumbra. The evaluation of the putative target genes of Nrf2, NAD(P)H: quinone oxidoreductase (NQO1)and heme oxygenase (decycling) 1 (Hamox1), revealed a tMCAO-induced upregulation of these anti-oxidative enzymes on mRNA. Gonadal hormones significantly intensified NQO1 but not Hamox1 expression. These data clearly indicate the short-term neuroprotective potency of a combined treatment with E and P under ischemic conditions in both genders in a rat model. We assume that the dampening of the early local neuroinflammation and the reduction of oxidative stress are both crucial for this neuroprotective action. Further experimental studies are required to analyze the long-term efficacy of both steroids under ischemic coinditions before translational studies in human patients can be started