Superhelasticity in aged single crystals of FeMnAlNi alloy

На [112]-монокристаллах Fe[43,5]Mnx[34]Al[15]Ni[7,5] показано, что при старении при T=437 K, 3 h наблюдается высокотемпературная сверхэластичность при деформации растяжением в температурном интервале от 298 K до 473 K. Экспериментально установлено, что механические и функциональные свойства зависят от ориентации кристалла, которая определяет вклад деформации раздвойникованием [epsilon][detw] в теоретическую величину деформации решетки

Alterations in peptide levels in Parkinson's disease and incidental Lewy body disease

The levels of the neuropeptides Met- and Leu-enkephalin (MET-ENK, LEU-ENK), substance P and neurotensin were measured by a combined high performance liquid chromatography/radioimmunoassay (HPLC/RIA) method in postmortem samples of basal ganglia from Parkinson's disease patients, incidental Lewy body disease patients (presymptomatic Parkinson's disease) and matched controls. Dopamine (DA) levels were reduced in the caudate nucleus and putamen in Parkinson's disease, but unaltered in incidental Lewy body disease. The levels of MET-ENK were reduced in the caudate nucleus, putamen and substantia nigra in Parkinson's disease. Met-enkephalin levels were reduced in the caudate nucleus and in the putamen in incidental Lewy body disease. Leu-enkephalin levels were decreased in the putamen and were undetectable in the substantia nigra in Parkinson's disease. Leu-enkephalin levels were unchanged in incidental Lewy body disease, although there was a tendency to a reduction in putamen. Substance P levels were reduced in the putamen in Parkinson's disease. No significant changes in substance P content were observed in incidental Lewy body disease. Neurotensin levels were increased in the substantia nigra in Parkinson's disease. Neurotensin levels in incidental Lewy body disease were not altered significantly, but tended to parallel the changes in Parkinson's disease. The changes in basal ganglia peptide levels in incidental Lewy body disease generally followed a trend similar to those seen in Parkinson's disease, but were less marked. This suggests that they are an integral part of the pathology of the illness and not secondary to DA neuronal loss or a consequence of prolonged drug therapy.Peer Reviewe

Optimizing sequencing protocols for leaderboard metagenomics by combining long and short reads.

As metagenomic studies move to increasing numbers of samples, communities like the human gut may benefit more from the assembly of abundant microbes in many samples, rather than the exhaustive assembly of fewer samples. We term this approach leaderboard metagenome sequencing. To explore protocol optimization for leaderboard metagenomics in real samples, we introduce a benchmark of library prep and sequencing using internal references generated by synthetic long-read technology, allowing us to evaluate high-throughput library preparation methods against gold-standard reference genomes derived from the samples themselves. We introduce a low-cost protocol for high-throughput library preparation and sequencing

Организация продажи продуктов питания через интернет

Рассмотрение экономических, управленческих и технических аспектов создания стартапа. Проведение исследования потребительских предпочтений на основе технологии Customer Development. Осуществление подготовки проекта стартапа. Объектом исследования является проект "S-Market" - приложение и веб-страница по продажи продуктов on-line в г. Томск. Предметом исследования является процесс создания старт-ап проекта при выведении нового продукта на рынок. Цель работы – разработка старт-ап плана по выведению нового продукта (приложения и веб-страницу) проекта "S-Market" на томский рынок онлайн-продаж продуктов питания.Consideration of economic, managerial and technical aspects creating a startup. Conducting research consumer preferences based Technology Customer Development. Training startup project. The object of the study is the S-Market project - an application and a web page for selling on-line products in Tomsk. The subject of the study is the process of creating a start-up project when introducing a new product to the market. The purpose of the work is to develop a start-up plan for introducing a new product (application and web page) of the S-Market project to the Tomsk market for online food sales

Анализ напряженно-деформированного состояния компенсаторов при проектировании нефтепроводов с использованием программного комплекса ANSYS

В работе рассмотрены характеристики исследуемого объекта – термокомпенсационные блоки на участке нефтепровода "Заполярье-Пурпе". Приведен расчет толщины стенки трубопровода, проверка его прочности и устойчивости, расчет компенсатора и его компенсирующей способности. Выполнено моделирование компенсаторов различного типа в программном комплексе Autodesk Inventor. Проведен анализ напряженно-деформированного состояния конструкций в программной среде ANSYS.The paper describes the characteristics of the studied object - thermal compensation blocks on the section of the Zapolyarye-Purpe oil pipeline. The calculation of the wall thickness of the pipeline, the verification of its strength and stability, the calculation of the compensator and its compensating ability. Compensators of various types have been simulated in the Autodesk Inventor software package. The analysis of the stress-strain state of structures in the ANSYS program is carried out