Evidence for a Massive Dark Object in NGC 4350

In this work we build a detailed dynamic model for a S0 galaxy possibly hosting a central massive dark object (MDO). We show that the photometric profiles and the kinematics along the major and minor axes, including the h3 and h4 profiles, imply the presence of a central MDO of mass M = 1.5 - 9.7 10^8 solar masses, i.e. 0.3-2.8% of the mass derived for the stellar spheroidal component. Models without MDO are unable to reproduce the kinematic properties of the inner stars and of the rapidly rotating nuclear gas. The stellar population comprise of an exponential disc (27% of the light) and a diffuse spheroidal component (73% of the light) that cannot be represented by a simple de Vaucouleurs profile at any radius. The M/L ratios we found for the stellar components (respectively 3.3 and 6.6) are typical of those of disc and elliptical galaxies.Comment: 9 pages, 4 encapsulated postscript figures. Requires mn.sty, psfig.sty. Accepted for publication in MNRA

Disfranchisement, Women\u27s Suffrage and the Failure of Florida\u27s Grandfather Clause

Following the adoption of the Constitution of 1885, Florida joined its sister southern states in enacting a series of election laws aimed at disfranchising black voters. This statutory labyrinth, with the Democratic party’s white primary system as its centerpiece, had all but excluded the state’s African-American citizens from the political arena by 1913. Although virtually complete in its practical effects, that process legally operated only in the primary elections. African-American males remained technically eligible to vote in general elections if their poll taxes were paid. In the same period, women’s suffrage was intruding on the existing political structure from another direction with a momentum that clearly portended ultimate success. Although both movements focused on the most fundamental dynamic of American politics, the right to vote, each ran to its historical conclusion on essentially separate courses. Yet, for a brief period between 1915 and 1916, the two converged in a confusing and almost forgotten episode of Florida political history

Railroads, Farmers and Senatorial Politics: The Florida Commission in the 1890s

The 1887 Florida Legislature created the state’s first Railroad Commission to curb monopoly abuses by railroad companies. 1 The legislation, which vested regulatory jurisdiction in a three-person commission appointed by the governor, was popular and suited to the reform tenor of the times. It had passed unanimously in the house and with only three dissenting votes in the senate. 2 Yet, in a peculiar twist of Florida political history, the commission’s statutory basis was abruptly repealed only four years later. Florida’s intrastate rail service was left once again unfettered by regulatory constraints.3 Then, six years later, the legislature reestablished the commission in almost its original form.4 Such quick reversals of political direction strongly infer that collateral issues dominated the outcome on the main question of railroad regulation. The episode prompts a two-fold question: Why the repeal in the first place, and why reenactment six years later? This article explores the interrelated dynamics of senatorial elections prior to enactment of the 17th Amendment, the agrarian reform movement and railroad politics in the context of those questions

On syntheses of the X-ray background with power-law sources

The conditions under which the combined emission from power law sources can mimic the X-ray background (XRB) spectrum in the 3-50 keV range are considered in view of HEAO 1 A-2 experiment measurements, and it is confirmed that a good fit may be obtained. The required spectral properties of the component sources differ, however, from those observed for local active galactic nuclei. Constraints are deduced for both the low luminosity extension and evolution of such local objects, and it is shown that any other class of sources contributing to the X-ray background must be characterized by an energy spectral index lower than about 0.4, which is the mean index of the XRB, and exhibit sleeper spectra at higher energies

Spectroscopy of moderately high-redshift RCS-1 clusters

We present spectroscopic observations of 11 moderately high-redshift (z~0.7- 1.0) clusters from the first Red-Sequence Cluster Survey (RCS-1). We find excellent agreement between the red-sequence estimated redshift and the spectroscopic redshift, with a scatter of 10% at z>0.7. At the high-redshift end (z>~0.9) of the sample, we find two of the systems selected are projections of pairs of comparably rich systems, with red-sequences too close to discriminate in (R-z') colour. In one of these systems, the two components are close enough to be physically associated. For a subsample of clusters with sufficient spectroscopic members, we examine the correlation between B_gcR (optical richness) and the dynamical mass inferred from the velocity dispersion. We find these measurements to be compatible, within the relatively large uncertainties, with the correlation established at lower redshift for the X-ray selected CNOC1 clusters and also for a lower redshift sample of RCS-1 clusters. Confirmation of this and calibration of the scatter in the relation will require larger samples of clusters at these and higher redshifts. [abridged]Comment: AJ accepted. 30 pages, 7 figures (figure 5 reduced quality

CAIRNS: The Cluster And Infall Region Nearby Survey I. Redshifts and Mass Profiles

The CAIRNS (Cluster And Infall Region Nearby Survey) project is a spectroscopic survey of the infall regions surrounding eight nearby, rich, X-ray luminous clusters of galaxies. We collect 15665 redshifts (3471 new or remeasured) within \sim 5-10 Mpc of the centers of the clusters, making it the largest study of the infall regions of clusters. We determine cluster membership and the mass profiles of the clusters based on the phase space distribution of the galaxies. All of the clusters display decreasing velocity dispersion profiles. The mass profiles are fit well by functional forms based on numerical simulations but exclude an isothermal sphere. Specifically, NFW and Hernquist models provide good descriptions of cluster mass profiles to their turnaround radii. Our sample shows that the predicted infall pattern is ubiquitous in rich, X-ray luminous clusters over a large mass range. The caustic mass estimates are in excellent agreement with independent X-ray estimates at small radii and with virial estimates at intermediate radii. The mean ratio of the caustic mass to the X-ray mass is 1.03\pm0.11 and the mean ratio of the caustic mass to the virial mass (when corrected for the surface pressure term) is 0.93\pm0.07. We further demonstrate that the caustic technique provides reasonable mass estimates even in merging clusters.Comment: 54 pages, 18 figures, to appear in The Astronomical Journa

Vascular endothelial growth factor C disrupts the endothelial lymphatic barrier to promote colorectal cancer invasion

Background & Aims Colorectal cancer (CRC) is highly metastatic. Metastases spread directly into local tissue or invade distant organs via blood and lymphatic vessels, but the role of lymphangiogenesis in CRC progression has not been determined. Lymphangiogenesis is induced via vascular endothelial growth factor C (VEGFC) activation of its receptor, VEGFR3; high levels of VEGFC have been measured in colorectal tumors undergoing lymphangiogenesis, and correlated with metastasis. We investigated VEGFC signaling and lymphatic barriers in human tumor tissues and mice with orthotopic colorectal tumors. Methods We performed immunohistochemical, immunoblot, and real-time PCR analyses of colorectal tumor specimens collected from patients; healthy intestinal tissues collected during surgeries of patients without CRC were used as controls. CT26 CRC cells were injected into the distal posterior rectum of BALB/c-nude mice. Mice were given injections of an antibody against VEGFR3 or an adenovirus encoding human VEGFC before orthotopic tumors and metastases formed. Lymph node, lung, and liver tissues were collected and evaluated by flow cytometry. We measured expression of vascular endothelial cadherin (CDH5) on lymphatic vessels in mice and in human intestinal lymphatic endothelial cells. Results Levels of podoplanin (a marker of lymphatic vessels), VEGFC, and VEGFR3 were increased in colorectal tumor tissues, compared with controls. Mice that expressed VEGFC from the adenoviral vector had increased lymphatic vessel density and more metastases in lymph nodes, lungs, and livers, compared with control mice. Anti-VEGR3 antibody reduced numbers of lymphatic vessels in colons and prevented metastasis. Expression of VEGFC compromised the lymphatic endothelial barrier in mice and endothelial cells, reducing expression of CDH5, increasing permeability, and increasing trans-endothelial migration by CRC cells. Opposite effects were observed in mice and cells when VEGFR3 was blocked. Conclusions VEGFC signaling via VEGFR3 promotes lymphangiogenesis and metastasis by orthotopic colorectal tumors in mice and reduces lymphatic endothelial barrier integrity. Levels of VEGFC and markers of lymphatic vessels are increased in CRC tissues from patients, compared with healthy intestine. Strategies to block VEGFR3 might be developed to prevent CRC metastasis in patients