2 research outputs found
Targeted Isolation of Monoterpene Indole Alkaloids from <i>Palicourea sessilis</i>
Phytochemical investigation of the
alkaloid extract of <i>Palicourea sessilis</i> by LC-HRMS/MS
using molecular networking
and an in silico MS/MS fragmentation approach suggested the presence
of several new monoterpene indole alkaloids. These compounds were
isolated by semipreparative HPLC, and their structures confirmed by
means of HRMS, NMR, and ECD measurements as 4-<i>N</i>-methyllyaloside
(<b>3</b>), 4-<i>N</i>-methyl-3,4-dehydrostrictosidine
(<b>4</b>), 4β-hydroxyisodolichantoside (<b>6</b>), and 4α-hydroxyisodolichantoside (<b>7</b>), as well
as the known alkaloids alline (<b>1</b>), <i>N</i>-methyltryptamine (<b>2</b>), isodolichantoside (<b>5</b>), and 5-oxodolichantoside (<b>8</b>). In addition, the acetylcholinesterase
inhibitory activity of the compounds was evaluated up to 50 μM
Targeted Isolation of Monoterpene Indole Alkaloids from <i>Palicourea sessilis</i>
Phytochemical investigation of the
alkaloid extract of <i>Palicourea sessilis</i> by LC-HRMS/MS
using molecular networking
and an in silico MS/MS fragmentation approach suggested the presence
of several new monoterpene indole alkaloids. These compounds were
isolated by semipreparative HPLC, and their structures confirmed by
means of HRMS, NMR, and ECD measurements as 4-<i>N</i>-methyllyaloside
(<b>3</b>), 4-<i>N</i>-methyl-3,4-dehydrostrictosidine
(<b>4</b>), 4β-hydroxyisodolichantoside (<b>6</b>), and 4α-hydroxyisodolichantoside (<b>7</b>), as well
as the known alkaloids alline (<b>1</b>), <i>N</i>-methyltryptamine (<b>2</b>), isodolichantoside (<b>5</b>), and 5-oxodolichantoside (<b>8</b>). In addition, the acetylcholinesterase
inhibitory activity of the compounds was evaluated up to 50 μM