42 research outputs found

    May Measurement Month: results of 12 national blood pressure screening programmes between 2017 and 2019

    Get PDF
    The first May Measurement Month (MMM) campaign, a global blood pressure (BP) screening programme, began in 2017 as an initiative of the International Society of Hypertension.1 Two subsequent annual campaigns have also been completed in consecutive years2,3 and having had to defer activities due to the COVID-19 pandemic in 2020 the fourth campaign was run in 2021, the results of which are currently in press. Since its initiation in 2017, volunteers from more than 100 countries have participated. The aims of MMM have remained consistent from the start—to raise awareness of the importance of the measurement of BP at the individual and population level and to provide a temporary pragmatic solution to the shortfall in BP screening programmes in countries around the world

    Blood pressure screening in Mozambique: the May Measurement Month 2017 project-Sub-Saharan Africa

    Get PDF
    Elevated blood pressure (BP) is a growing burden worldwide, leading to over 10 million deaths each year. In Mozambique, two national surveys of risk factors for chronic diseases were done, using the WHO STEPWISE approach, the first in 2005 and the last in 2014/2015. In this period of 10 years, the prevalence of hypertension in the adult population increased from 33.1% to 38.9% and the extremely low levels of awareness, treatment, and control did not change significantly. May Measurement Month (MMM) is a global initiative of the International Society of Hypertension aimed at raising awareness of high BP and to act as a temporary solution to the lack of screening programmes worldwide. An opportunistic cross-sectional survey of volunteers aged ≥18 years was carried out in May 2017. Blood pressure measurement, the definition of hypertension and statistical analysis followed the standard MMM protocol. Screening was conducted by volunteers, mainly in work places, markets, and religious activities, in the capital city, in most of the provincial capitals and some rural districts. About 4454 individuals were screened with a mean age of 39 years, and, after multiple imputation, 1371 (31.1%) had hypertension. Of individuals not receiving anti-hypertensive medication, 1099 (26.6%) were hypertensive. Of individuals receiving antihypertensive medication, 166 (61.6%) had uncontrolled BP. MMM17 was the largest BP screening campaign undertaken in Mozambique. These results suggest that opportunistic screening is an important tool to identify significant numbers of patients with raised BP

    Hypertension in Sub-Saharan Africa: Cross-Sectional Surveys in Four Rural and Urban Communities

    Get PDF
    Background: Cardiovascular disease (CVD) is the leading cause of adult mortality in low-income countries but data on the prevalence of cardiovascular risk factors such as hypertension are scarce, especially in sub-Saharan Africa (SSA). This study aims to assess the prevalence of hypertension and determinants of blood pressure in four SSA populations in rural Nigeria and Kenya, and urban Namibia and Tanzania. Methods and Findings: We performed four cross-sectional household surveys in Kwara State, Nigeria; Nandi district, Kenya; Dar es Salaam, Tanzania and Greater Windhoek, Namibia, between 2009-2011. Representative population-based samples were drawn in Nigeria and Namibia. The Kenya and Tanzania study populations consisted of specific target groups. Within a final sample size of 5,500 households, 9,857 non-pregnant adults were eligible for analysis on hypertension. Of those, 7,568 respondents ≥18 years were included. The primary outcome measure was the prevalence of hypertension in each of the populations under study. The age-standardized prevalence of hypertension was 19.3% (95%CI:17.3-21.3) in rural Nigeria, 21.4% (19.8-23.0) in rural Kenya, 23.7% (21.3-26.2) in urban Tanzania, and 38.0% (35.9-40.1) in urban Namibia. In individuals with hypertension, the proportion of grade 2 (≥160/100 mmHg) or grade 3 hypertension (≥180/110 mmHg) ranged from 29.2% (Namibia) to 43.3% (Nigeria). Control of hypertension ranged from 2.6% in Kenya to 17.8% in Namibia. Obesity prevalence (BMI ≥30) ranged from 6.1% (Nigeria) to 17.4% (Tanzania) and together with age and gender, BMI independently predicted blood pressure level in all study populations. Diabetes prevalence ranged from 2.1% (Namibia) to 3.7% (Tanzania). Conclusion: Hypertension was the most frequently observed risk factor for CVD in both urban and rural communities in SSA and will contribute to the growing burden of CVD in SSA. Low levels of control of hypertension are alarming. Strengthening of health care systems in SSA to contain the emerging epidemic of CVD is urgently needed

    Nanorings and rods interconnected by self-assembly mimicking an artificial network of neurons

    Full text link
    [EN] Molecular electronics based on structures ordered as neural networks emerges as the next evolutionary milestone in the construction of nanodevices with unprecedented applications. However, the straightforward formation of geometrically defined and interconnected nanostructures is crucial for the production of electronic circuitry nanoequivalents. Here we report on the molecularly fine-tuned self-assembly of tetrakis-Schiff base compounds into nanosized rings interconnected by unusually large nanorods providing a set of connections that mimic a biological network of neurons. The networks are produced through self-assembly resulting from the molecular conformation and noncovalent intermolecular interactions. These features can be easily generated on flat surfaces and in a polymeric matrix by casting from solution under ambient conditions. The structures can be used to guide the position of electron-transporting agents such as carbon nanotubes on a surface or in a polymer matrix to create electrically conducting networks that can find direct use in constructing nanoelectronic circuits.The research leading to these results has received funding from ICIQ, ICREA, the Spanish Ministerio de Economia y Competitividad (MINECO) through project CTQ2011-27385 and the European Community Seventh Framework Program (FP7-PEOPLE-ITN-2008, CONTACT consortium) under grant agreement number 238363. We acknowledge E. C. Escudero-Adan, M. Martinez-Belmonte and E. Martin from the X-ray department of ICIQ for crystallographic analysis, and M. Moncusi, N. Argany, R. Marimon, M. Stefanova and L. Vojkuvka from the Servei de Recursos Cientifics i Tecnics from Universitat Rovira i Virgili (Tarragona, Spain).Escarcega-Bobadilla, MV.; Zelada-Guillen, GA.; Pyrlin, SV.; Wegrzyn, M.; Ramos, MMD.; Giménez Torres, E.; Stewart, A.... (2013). Nanorings and rods interconnected by self-assembly mimicking an artificial network of neurons. Nature Communications. 4:2648-2648. https://doi.org/10.1038/ncomms3648S264826484Champness, N. R. Making the right connections. Nat. Chem. 4, 149–150 (2012).Hopfield, J. J. & Tank, D. W. Computing with neural circuits: A model. Science 233, 625–633 (1986).Andres, P. R. et al. Self-assembly of a two-dimensional superlattice of molecularly linked metal clusters. Science 273, 1690–1693 (1996).Eichen, Y., Braun, E., Sivan, U. & Ben-Yoseph, G. Self-assembly of nanoelectronic components and circuits using biological templates. Acta Polym. 49, 663–670 (1998).Kawakami, T. et al. Possibilities of molecule-based spintronics of DNA wires, sheets, and related materials. Int. J. Quantum Chem. 105, 655–671 (2005).Kashtan, N., Itzkovitz, S., Milo, R. & Alon, U. Topological generalizations of network motifs. Phys. Rev. E 70, 031909 (2004).Grill, L. et al. Nano-architectures by covalent assembly of molecular building blocks. Nat. Nanotech. 2, 687–691 (2007).Lafferentz, L. et al. Controlling on-surface polymerization by hierarchical and substrate-directed growth. Nat. Chem. 4, 215–220 (2012).Alivisatos, A. P. et al. From molecules to materials: current trends and future directions. Adv. Mater. 10, 1297–1336 (1998).Pauling, L. The principles determining the structure of complex ionic crystals. J. Am. Chem. Soc. 51, 1010–1026 (1929).Damasceno, P. F., Engel, M. & Glotzer, S. C. Predictive self-assembly of polyhedra into complex structures. Science 337, 453–457 (2012).De Graaf, J. & Manna, L. A roadmap for the assembly of polyhedral particles. Science 337, 417–418 (2012).Percec, V. et al. Controlling polymer shape through the self-assembly of dendritic side-groups. Nature 391, 161–164 (1998).Stupp, S. I. et al. Supramolecular materials: self-organized nanostructures. Science 276, 384–389 (1997).Mann, S. The chemistry of form. Angew. Chem. Int. Ed. 39, 3392–3406 (2000).Sakakibara, K., Hill, J. P. & Ariga, K. Thin-film-based nanoarchitectures for soft matter: controlled assemblies into two-dimensional worlds. Small 7, 1288–1308 (2011).Huang, Z. et al. Pulsating tubules from noncovalent macrocycles. Science 337, 1521–1526 (2012).Ackermann, D., Jester, S.-S. & Famulok, M. Design strategy for DNA rotaxanes with a mechanically reinforced PX100 axle. Angew. Chem. Int. Ed. 27, 6771–6775 (2012).Marx, J. L. Microtubules: versatile organelles. Science 181, 1236–1237 (1973).Heus, H. A. & Pardi, A. Structural features that give rise to the unusual stability of RNA hairpins containing GNRA loops. Science 253, 191–194 (1991).Braun, E., Eichen, Y., Sivan, U. & Ben-Yoseph, G. DNA-templated assembly and electrode attachment of a conducting silver wire. Nature 391, 775–778 (1998).Zhang, S. Fabrication of novel biomaterials through molecular self-assembly. Nat. Biotechnol. 21, 1171–1178 (2003).Cai, X. et al. Integrated compact optical vortex beam emitters. Science 338, 363–365 (2012).Clark, A. W. & Cooper, J. M. Nanogap ring antennae as plasmonically coupled SERRS substrates. Small 7, 119–125 (2011).Armani, A. M., Kulkarni, R. P., Fraser, S. E., Flagan, R. C. & Vahala, K. J. Label-free, single-molecule detection with optical microcavities. Science 317, 783–787 (2007).Frischmann, P. D., Guieu, S., Tabeshi, R. & MacLachlan, M. J. Columnar organization of head-to-tail self-assembled Pt4 rings. J. Am. Chem. Soc. 132, 7668–7675 (2010).Frischmann, P. D. et al. Capsule formation, carboxylate exchange, and DFT exploration of cadmium cluster metallocavitands: highly dynamic supramolecules. J. Am. Chem. Soc. 132, 3893–3908 (2010).Akine, S., Hotate, S. & Nabeshima, T. A molecular leverage for helicity control and helix Inversion. J. Am. Chem. Soc. 133, 13868–13871 (2011).Salassa, G. et al. Extremely strong self-assembly of a bimetallic salen complex visualized at the single-molecule level. J. Am. Chem. Soc. 134, 7186–7192 (2012).Escárcega-Bobadilla, M. V., Salassa, G., Martínez Belmonte, M., Escudero-Adán, E. C. & Kleij, A. W. Versatile switching in substrate topicity: supramolecular chirality induction in di- and trinuclear host complexes. Chem. Eur. J. 18, 6805–6810 (2012).Frischmann, P. D., Jiang, J., Hui, J. K.-H., Grzybowski, J. J. & MacLachlan, M. J. Reversible—irreversible approach to Schiff base macrocycles. Access to isomeric macrocycles with multiple salphen pockets. Org. Lett. 10, 1255–1258 (2008).Glaser, T. Rational design of single-molecule magnets: a supramolecular approach. Chem. Commun. 47, 116–130 (2011).Lee, E. C. et al. Understanding of assembly phenomena by aromatic−aromatic interactions: benzene dimer and the substituted systems. J. Phys. Chem. A 111, 3446–3457 (2007).Grybowski, B. A., Wilmer, C. E., Kim, J., Browne, K. P. & Bishop, K. J. M. Self-assembly: from crystals to cells. Soft Matter. 5, 1110–1128 (2009).Martínez Belmonte, M. et al. Self-assembly of Zn(salphen) complexes: steric regulation, stability studies and crystallographic analysis revealing an unexpected dimeric 3,3′-t-Bu-substituted Zn(salphen) complex. Dalton Trans. 39, 4541–4550 (2010).Salassa, G., Castilla, A. M. & Kleij, A. W. Cooperative self-assembly of a macrocyclic Schiff base complex. Dalton Trans. 40, 5236–5243 (2011).Hormoz, S. & Brenner, M. P. Design principles for self-assembly with short-range interactions. Proc. Natl Acad. Sci. 108, 5193–5198 (2011).Biemans, H. A. M. et al. Hexakis porphyrinato benzenes. A new class of porphyrin arrays. J. Am. Chem. Soc. 120, 11054–11060 (1998).Lensen, M. C. et al. Aided self-assembly of porphyrin nanoaggregates into ring-shaped architectures. Chem. Eur. J. 10, 831–839 (2004).Martin, A., Buguin, A. & Brochard-Wyart, F. Dewetting nucleation centers at soft interfaces. Langmuir. 17, 6553–6559 (2001).Schenning, A. P. H. J., Benneker, F. B. G., Geurts, H. P. M., Liu, X. Y. & Nolte, R. J. M. Porphyrin wheels. J. Am. Chem. Soc. 118, 8549–8552 (1996).Deegan, R. D. et al. Capillary flow as the cause of ring strains from dried liquid drops. Nature 389, 827–829 (1997).Scriven, L. E. & Sternling, C. V. The Marangoni effects. Nature 187, 186–188 (1960).Cai, Y. & Newby, B. Z. Marangoni flow-induced self-assembly of hexagonal and stripe-like nanoparticle patterns. J. Am. Chem. Soc. 130, 6076–6077 (2008).Whitesides, G. M. & Grzybowski, B. Self-assembly at all scales. Science 295, 2418–2421 (2002).Mann, S. Self-assembly and transformation of hybrid nano-objects and nanostructures under equilibrium and non-equilibrium conditions. Nat. Mater. 8, 781–792 (2009).Gröschnel, A. H. et al. Precise hierarchical self-assembly of multicompartment micelles. Nat. Commun. 3, 710 (2012).Adam, M., Dogic, Z., Keller, S. L. & Fraden, S. Entropically driven microphase transitions in mixtures of colloidal rods and spheres. Nature 393, 349–352 (1998).Ohara, P. C., Heath, J. R. & Gelbart, W. M. Self-assembly of submicrometer rings of particles from solutions of nanoparticles. Angew. Chem. Int. Ed. 36, 1077–1080 (1997).Xu, J., Xia, J. & Lin, Z. Evaporation-induced self-assembly of nanoparticles from a sphere-on-flat geometry. Angew. Chem. Int. Ed. 46, 1860–1863 (2007).Yosef, G. & Rabani, E. Self-assembly of nanoparticles into rings: A lattice-gas model. J. Phys. Chem. B 110, 20965–20972 (2006).Khanal, B. P. & Zubarev, E. R. Rings of nanorods. Angew. Chem. Int. Ed. 46, 2195–2198 (2007).Wang, Z. et al. One-step, self-assembly, alignment, and patterning of organic semiconductor nanowires by controlled evaporation of confined microfluids. Angew. Chem. Int. Ed. 50, 2811–2815 (2011).Hong, S. W. et al. Directed self-assembly of gradient concentric carbon nanotube rings. Adv. Func. Mater. 18, 2114–2122 (2008).Palma, M. et al. Controlled formation of carbon nanotube junctions via linker-induced assembly in aqueous solution. J. Am. Chem. Soc. 135, 8440–8443 (2013).Horcas, I. et al. WSXM: A software for scanning probe microscopy and a tool for nanotechnology. Rev. Sci. Instrum. 78, 013705 (2007).Soler, J. M. et al. The SIESTA method for ab initio order-n materials simulation. J. Phys. Cond. Matter 14, 2745–2779 (2002).Haynes, P. D., Mostof, A. A., Skylaris, C. & Payne, M. C. ONETEP: Linear-scaling density-functional theory with plane-waves. J. Phys. Conf. Ser. 26, 143–148 (2006).Valiev, M. et al. NWCHEM: A comprehensive and scalable open-source solution for large scale molecular simulations. Comp. Phys. Commun. 181, 1477–1489 (2010).Plimpton, S. Fast parallel algorithms for short-range molecular dynamics. J. Comp. Phys. 117, 1–19 (1995)
    corecore