Teacher Contract Non-Renewal in the Rocky Mountains

Success for students in the 21st century increasingly relies on competencies and proficiencies typically available on]y through formal educational processes. Researchers have noted the paramount importance of quality teaching as the important criterion for student success (Haycock, 1998; Marzano, 2003). Recent reforms have increased the expectation that school principals energetically address teacher evaluations and subsequently remove ineffective teachers. These recent reforms tend to have common priorities, including emphasizing high quality teaching, evaluating teachers for merit pay purposes, and linking evaluation to student performance with an emphasis on the removal of ineffective teachers from the classroom

Issue 13: Syrian Refugee Resettlement and the Role of Local Immigration Partnerships (LIPs) in Ontario, Canada

During the peak of the Syrian refugee “crisis” in 2015 and early 2016, the Canadian Federal Government responded with a push to drastically increase the number of Syrian refugees it planned to resettle. The resulting Syrian Refugee Resettlement Initiative (SRRI) put to the test Local Immigration Partnerships (LIPs), a form of place-based policy that had been in place since 2008 where communities collaborate in the support, development and execution of local immigration and refugee resettlement plans. This issue of Policy Points discusses a study of three LIPs (Hamilton, Ottawa, and Waterloo Region) and their response to the SRRI. The research provides three policy insights relevant to refugee and immigrant community resettlement. Bringing the community into the fold through multi stakeholder tables such as LIPs can coordinate local responses to the resettlement of refugees (policy insight 1). LIPs must be embedded in the local community and include leaders and personnel able to build and enhance local stakeholder networks (policy insight 2). Finally, it is key to involve LIPs in communication channels during mass resettlement events (policy insight 3). Policy action under points 2 and 3 will in turn enable LIPs to effectively support refugee resettlement at the local level. The experience of the three Ontario LIPs in this study is relevant to existing and potential new LIPs, but it also offers a unique place-based policy approach to engaging local communities in resettlement at other locations and scales

Issue 13: Syrian Refugee Resettlement and the Role of Local Immigration Partnerships (LIPs) in Ontario, Canada

During the peak of the Syrian refugee “crisis” in 2015 and early 2016, the Canadian Federal Government responded with a push to drastically increase the number of Syrian refugees it planned to resettle. The resulting Syrian Refugee Resettlement Initiative (SRRI) put to the test Local Immigration Partnerships (LIPs), a form of place-based policy that had been in place since 2008 where communities collaborate in the support, development and execution of local immigration and refugee resettlement plans. This issue of Policy Points discusses a study of three LIPs (Hamilton, Ottawa, and Waterloo Region) and their response to the SRRI. The research provides three policy insights relevant to refugee and immigrant community resettlement. Bringing the community into the fold through multi stakeholder tables such as LIPs can coordinate local responses to the resettlement of refugees (policy insight 1). LIPs must be embedded in the local community and include leaders and personnel able to build and enhance local stakeholder networks (policy insight 2). Finally, it is key to involve LIPs in communication channels during mass resettlement events (policy insight 3). Policy action under points 2 and 3 will in turn enable LIPs to effectively support refugee resettlement at the local level. The experience of the three Ontario LIPs in this study is relevant to existing and potential new LIPs, but it also offers a unique place-based policy approach to engaging local communities in resettlement at other locations and scales

Status Report of the DPHEP Study Group: Towards a Global Effort for Sustainable Data Preservation in High Energy Physics

Data from high-energy physics (HEP) experiments are collected with significant financial and human effort and are mostly unique. An inter-experimental study group on HEP data preservation and long-term analysis was convened as a panel of the International Committee for Future Accelerators (ICFA). The group was formed by large collider-based experiments and investigated the technical and organisational aspects of HEP data preservation. An intermediate report was released in November 2009 addressing the general issues of data preservation in HEP. This paper includes and extends the intermediate report. It provides an analysis of the research case for data preservation and a detailed description of the various projects at experiment, laboratory and international levels. In addition, the paper provides a concrete proposal for an international organisation in charge of the data management and policies in high-energy physics

Time to Osteoporosis and Major Fracture in Older Men

For older men who undergo bone mineral density (BMD) testing, the optimal osteoporosis screening schedule is unknown. Time-to-disease estimates are necessary to inform screening intervals

Time to Osteoporosis and Major Fracture in Older Men

For older men who undergo bone mineral density (BMD) testing, the optimal osteoporosis screening schedule is unknown. Time-to-disease estimates are necessary to inform screening intervals

US Scientific Leadership Addressing Energy, Ecosystems, Climate, and Sustainable Prosperity: Report in Brief from the BERAC Subcommittee on International Benchmarking

This document presents the subcommittee’s overarching and domain-specific findings and recommendations for the next decade, identified by consensus across the full BERAC subcommittee and experts interviewed for this assessment

In Vivo Fluorescence Immunohistochemistry:Localization of Fluorescently Labeled Cetuximab in Squamous Cell Carcinomas

Anti-EGFR (epidermal growth factor receptor) antibody based treatment strategies have been successfully implemented in head and neck squamous cell carcinoma (HNSCC). Unfortunately, predicting an accurate and reliable therapeutic response remains a challenge on a per-patient basis. Although significant efforts have been invested in understanding EGFR-mediated changes in cell signaling related to treatment efficacy, the delivery and histological localization in (peri-) tumoral compartments of antibody-based therapeutics in human tumors is poorly understood nor ever made visible. In this first in-human study of a systemically administered near-infrared (NIR) fluorescently labeled therapeutic antibody, cetuximab-IRDye800CW (2.5 mg/m(2), 25 mg/m(2), and 62.5 mg/m(2)), we show that by optical molecular imaging (i.e. denominated as In vivo Fluorescence Immunohistochemistry) we were able to evaluate localization of fluorescently labeled cetuximab. Clearly, optical molecular imaging with fluorescently labeled antibodies correlating morphological (peri-) tumoral characteristics to levels of antibody delivery, may improve treatment paradigms based on understanding true tumoral antibody delivery

Dementia Revealed: Novel Chromosome 6 Locus for Late-Onset Alzheimer Disease Provides Genetic Evidence for Folate-Pathway Abnormalities

Genome-wide association studies (GWAS) of late-onset Alzheimer disease (LOAD) have consistently observed strong evidence of association with polymorphisms in APOE. However, until recently, variants at few other loci with statistically significant associations have replicated across studies. The present study combines data on 483,399 single nucleotide polymorphisms (SNPs) from a previously reported GWAS of 492 LOAD cases and 496 controls and from an independent set of 439 LOAD cases and 608 controls to strengthen power to identify novel genetic association signals. Associations exceeding the experiment-wide significance threshold () were replicated in an additional 1,338 cases and 2,003 controls. As expected, these analyses unequivocally confirmed APOE's risk effect (rs2075650, ). Additionally, the SNP rs11754661 at 151.2 Mb of chromosome 6q25.1 in the gene MTHFD1L (which encodes the methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like protein) was significantly associated with LOAD (; Bonferroni-corrected P = 0.022). Subsequent genotyping of SNPs in high linkage disequilibrium () with rs11754661 identified statistically significant associations in multiple SNPs (rs803424, P = 0.016; rs2073067, P = 0.03; rs2072064, P = 0.035), reducing the likelihood of association due to genotyping error. In the replication case-control set, we observed an association of rs11754661 in the same direction as the previous association at P = 0.002 ( in combined analysis of discovery and replication sets), with associations of similar statistical significance at several adjacent SNPs (rs17349743, P = 0.005; rs803422, P = 0.004). In summary, we observed and replicated a novel statistically significant association in MTHFD1L, a gene involved in the tetrahydrofolate synthesis pathway. This finding is noteworthy, as MTHFD1L may play a role in the generation of methionine from homocysteine and influence homocysteine-related pathways and as levels of homocysteine are a significant risk factor for LOAD development