8,016 research outputs found
Field Quantization, Photons and Non-Hermitean Modes
Field quantization in three dimensional unstable optical systems is treated
by expanding the vector potential in terms of non-Hermitean (Fox-Li) modes in
both the cavity and external regions. The cavity non-Hermitean modes (NHM) are
treated using the paraxial and monochromaticity approximations. The NHM
bi-orthogonality relationships are used in a standard canonical quantization
procedure based on introducing generalised coordinates and momenta for the
electromagnetic (EM) field. The quantum EM field is equivalent to a set of
quantum harmonic oscillators (QHO), associated with either the cavity or the
external region NHM. This confirms the validity of the photon model in unstable
optical systems, though the annihilation and creation operators for each QHO
are not Hermitean adjoints. The quantum Hamiltonian for the EM field is the sum
of non-commuting cavity and external region contributions, each of which is sum
of independent QHO Hamiltonians for each NHM, but the external field
Hamiltonian also includes a coupling term responsible for external NHM photon
exchange processes. Cavity energy gain and loss processes is associated with
the non-commutativity of cavity and external region operators, given in terms
of surface integrals involving cavity and external region NHM functions on the
cavity-external region boundary. The spontaneous decay of a two-level atom
inside an unstable cavity is treated using the essential states approach and
the rotating wave approximation. Atomic transitions leading to cavity NHM
photon absorption have a different coupling constant to those leading to photon
emission, a feature resulting from the use of NHM functions. Under certain
conditions the decay rate is enhanced by the Petermann factor.Comment: 38 pages, tex, 2 figures, ps. General expression for decay rate
added. To be published in Journal of Modern Optic
Design of an integrated shallow water wave experiment
The experimental design and instrumentation for an integrated shallow-water surface gravity wave experiment is discussed. The experiment required the measurement of the water surface elevation, meteorological parameters, and directional spectra at a number of locations on a shallow lake. In addition, to acquire data under a wide range of conditions, an experimental period of three years was required. A system of telephone and radio modem links were installed to enable real-time monitoring of instrument performance at eight separate measurement locations on the lake. This system also enabled logging sessions to be optimized to ensure the maximum possible data return from this extended experimentIEEE Oceanic Engineering Societ
The rodent research animal holding facility as a barrier to environmental contamination
The rodent Research Animal Holding Facility (RAHF), developed by NASA Ames Research Center (ARC) to separately house rodents in a Spacelab, was verified as a barrier to environmental contaminants during a 12-day biocompatibility test. Environmental contaminants considered were solid particulates, microorganisms, ammonia, and typical animal odors. The 12-day test conducted in August 1988 was designed to verify that the rodent RAHF system would adequately support and maintain animal specimens during normal system operations. Additional objectives of this test were to demonstrate that: (1) the system would capture typical particulate debris produced by the animal; (2) microorganisms would be contained; and (3) the passage of animal odors was adequately controlled. In addition, the amount of carbon dioxide exhausted by the RAHF system was to be quantified. Of primary importance during the test was the demonstration that the RAHF would contain particles greater than 150 micrometers. This was verified after analyzing collection plates placed under exhaust air ducts and rodent cages during cage maintenance operations, e.g., waste tray and feeder changeouts. Microbiological testing identified no additional organisms in the test environment that could be traced to the RAHF. Odor containment was demonstrated to be less than barely detectable. Ammonia could not be detected in the exhaust air from the RAHF system. Carbon dioxide levels were verified to be less than 0.35 percent
Atmospheric and Oceanographic Information Processing System (AOIPS) system description
The development of hardware and software for an interactive, minicomputer based processing and display system for atmospheric and oceanographic information extraction and image data analysis is described. The major applications of the system are discussed as well as enhancements planned for the future
Novel mutations in the BRCA1 and BRCA2 genes in Iranian women with early-onset breast cancer
BACKGROUND:
Breast cancer is the most common female malignancy and a major cause of death in middle-aged women. So far, germline mutations in the BRCA1 and BRCA2 genes in patients with early-onset breast and/or ovarian cancer have not been identified within the Iranian population.
METHODS:
With the collaboration of two main centres for cancer in Iran, we obtained clinical information, family history and peripheral blood from 83 women under the age of 45 with early-onset breast cancer for scanning of germline mutations in the BRCA1 and BRCA2 genes. We analysed BRCA1 exons 11 and BRCA2 exons 10 and 11 by the protein truncation test, and BRCA1 exons 2, 3, 5, 13 and 20 and BRCA2 exons 9, 17, 18 and 23 with the single-strand conformation polymorphism assay on genomic DNA amplified by polymerase chain reaction.
RESULTS:
Ten sequence variants were identified: five frameshifts (putative mutations – four novel); three missense changes of unknown significance and two polymorphisms, one seen commonly in both Iranian and British populations.
CONCLUSIONS
Identification of these novel mutations suggests that any given population should develop a mutation database for its programme of breast cancer screening. The pattern of mutations seen in the BRCA genes seems not to differ from other populations studied. Early-onset breast cancer (less than 45 years) and a limited family history is sufficient to justify mutation screening with a detection rate of over 25% in this group, whereas sporadic early-onset breast cancer (detection rate less than 5%) is unlikely to be cost-effective
Synchronized pulse control of decoherence
We present a new strategy for multipulse control over decoherence. When a
two-level system interacts with a reservoir characterized by a specific
frequency, we find that the decoherence is effectively suppressed by
synchronizing the pulse-train application with the dynamical motion of the
reservoir.Comment: 14 pages, 8 figure
Eta Carinae: Binarity Confirmed
We report the recovery of a spectroscopic event in eta Carinae in 1997/98
after a prediction by Damineli (1996). A true periodicity with P = 2020+-5 days
(0.2% uncertainty) is obtained. The line intensities and the radial-velocity
curve display a phase-locked behavior implying that the energy and dynamics of
the event repeat from cycle to cycle. This rules out S Doradus oscillation or
multiple shell ejection by an unstable star as the explanation of the
spectroscopic events. A colliding-wind binary scenario is supported by our
spectroscopic data and by X-ray observations. Although deviations from a simple
case exist around periastron, intensive monitoring during the next event (mid
2003) will be crucial to the understanding of the system.Comment: 13 pages, accepted by ApJ Letters (January 2000
Redshifts and Velocity Dispersions of Galaxy Clusters in the Horologium-Reticulum Supercluster
We present 118 new optical redshifts for galaxies in 12 clusters in the
Horologium-Reticulum supercluster (HRS) of galaxies. For 76 galaxies, the data
were obtained with the Dual Beam Spectrograph on the 2.3m telescope of the
Australian National University at Siding Spring Observatory. After combining 42
previously unpublished redshifts with our new sample, we determine mean
redshifts and velocity dispersions for 13 clusters, in which previous
observational data were sparse. In six of the 13 clusters, the newly determined
mean redshifts differ by more than 750 km/s from the published values. In the
case of three clusters, A3047, A3109, and A3120, the redshift data indicate the
presence of multiple components along the line of sight. The new cluster
redshifts, when combined with other reliable mean redshifts for clusters in the
HRS, are found to be distinctly bi-modal. Furthermore, the two redshift
components are consistent with the bi-modal redshift distribution found for the
inter-cluster galaxies in the HRS by Fleenor et al. (2005).Comment: 13 pages, 3 figures, Accepted to A
Patient-Reported Outcomes Measurement Information System physical function correlates with Toronto Extremity Salvage Score in an orthopaedic oncology population
Background: The National Institute of Health\u27s Patient-Reported Outcomes Measurement Information System (PROMIS) uses computerised-adaptive testing to reduce survey burden and improve sensitivity. PROMIS is being used across medical and surgical disciplines but has not been studied in orthopaedic oncology.
Questions/purposes: The aim of the study was to compare PROMIS measures with upper extremity (UE) and lower extremity (LE) Toronto Extremity Salvage Score (TESS) by assessing the following: (1) responder burden, (2) correlation between scores and (3) floor/ceiling effects.
Patients and methods: This cross-sectional trial analysed all 97 adult patients treated surgically for a bone or soft tissue tumour at a tertiary institution between November 2015 and March 2016. TESS (UE or LE) and PROMIS (Physical Function, Pain Interference and Depression) surveys were administered preoperatively. Pearson correlations between each PROMIS domain and TESS were calculated, as were floor/ceiling effects of each outcome measure.
Results: (1) Completion of three PROMIS questionnaires required a mean total of 16.8 (+/- 5.8 standard deviation) questions, compared with 31 and 32 questions for the LE and UE TESS questionnaires, respectively. (2) The PROMIS Physical Function scores demonstrated a strong positive correlation with the LE TESS (r = 0.84; 95% confidence interval [CI], 0.72-0.91; p \u3c 0.001) and moderate positive correlation with the UE TESS (r = 0.64; 95% CI, 0.34-0.83; p = 0.055). The PROMIS Depression scores demonstrated a weak negative correlation with both the LE TESS (r = -0.38; 95% CI, -0.61 to -0.10; p = 0.010) and with UE TESS (r = -0.38; 95% CI, -0.67 to -0.01; p = 0.055). The PROMIS Pain Interference scores demonstrated a strong negative correlation with the LE TESS (r = -0.71; 95% CI, -0.83 to -0.52; p \u3c 0.001) and a moderate negative correlation with the UE TESS (r = -0.62; 95% CI, -0.81 to -0.30; p = 0.001). (3) The UE TESS had a range of scores from 16 to 100 with a 27% ceiling effect and no floor effect, and the LE TESS had a range from 10 to 98 with no floor or ceiling effect. There was no floor or ceiling effect for any PROMIS measures.
Conclusions: In an orthopaedic oncology population, the PROMIS Physical Function and Pain Interference scores correlate with the TESS and have the benefit of reduced survey burden and ceiling effect. The PROMIS Depression scores may provide additional information regarding patient outcomes not captured by the TESS.
Level of Evidence: Level III.
The translational potential of this article: Patient reported outcome measures asses patients\u27 symptoms, function and health-related quality of life and are designed to capture more clinical information than can be gathered by objective medial testing alone. As reimbursements and the understanding of patient outcomes are becoming tied to performance on PROMIS measures, it is an important step to establish how PROMIS measures correlate and compare to traditional legacy measures
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