Conventional and unconventional treatments for migraine

Migraine is one of the leading causes of disability in humans. It causes significant deterioration in patients' lives and prevents daily functioning. Its main symptoms include photophobia, an enormous stabbing headache, nausea and vomiting. In addition, it can be accompanied by tinnitus, visual disturbances or dizziness. Before diagnosing migraine, serious intracranial pathology or other neurological conditions should be ruled out. Treatment of acute migraine is difficult due to significant rates of nonresponse to medications and the difficulty in predicting individual response to a particular agent or dose. A new class of drugs, calcitonin gene-related peptide (CGRP) antagonists, has been approved for the prevention of migraine in adults. In contrast, effective first-line therapies for mild to moderate migraine are over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs) and combination analgesics containing paracetamol, aspirin and caffeine

Food hypersensitivity - classification, pathogenesis, diagnosis. What are food allergies?

Introduction: Food hypersensitivity is a pathological, increased and inadequate reaction of the body to a particular substance, the consumption of which can cause various types of body symptoms. Purpose: The purpose of this study is to distinguish different types of hypersensitivity mechanisms, resulting in the introduction of appropriate diagnosis and treatment. Results and conclusions: Food hypersensitivity is becoming an epidemic of the 21st century. This is due to many individual factors as well as environmental pollution. It is important to identify the type of mechanism involved in a given food hypersensitivity and to eliminate the causative factors, or incorporate appropriate treatment. Understanding this forms the basis of therapy. Methods:  Data for the article were retrieved using PubMed setting the time descriptors to 2014-2020

Conventional and unconventional treatments for migraine

MIELNICZEK, Katarzyna, DOŁOMISIEWICZ, Diana, DALMATA, Weronika, GĄBKA, Ilona and DĄBROWSKI, Jan. Conventional and unconventional treatments for migraine. Journal of Education, Health and Sport. 2023;19(1):227-236. eISSN 2391-8306. http://dx.doi.org/10.12775/JEHS.2023.19.01.020 https://apcz.umk.pl/JEHS/article/view/45843 https://zenodo.org/record/8364590 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of 17.07.2023 No. 32318. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 17.07.2023 Lp. 32318. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2023; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 22.08.2023. Revised: 15.09.2023. Accepted: 20.09.2023. Published: 22.09.2023. Conventional and unconventional treatments for migraine Katarzyna Mielniczek1, Diana Dołomisiewicz2, Weronika Dalmata1, Ilona Gąbka1, Jan Dąbrowski1 1 Students' Scientific Circle at the Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin 2 Student Research Group at the Depatment of Neurology “NEKON”, Medical University of Warsaw Abstract Migraine is one of the leading causes of disability in humans. It causes significant deterioration in patients' lives and prevents daily functioning. Its main symptoms include photophobia, an enormous stabbing headache, nausea and vomiting. In addition, it can be accompanied by tinnitus, visual disturbances or dizziness. Before diagnosing migraine, serious intracranial pathology or other neurological conditions should be ruled out. Treatment of acute migraine is difficult due to significant rates of nonresponse to medications and the difficulty in predicting individual response to a particular agent or dose. A new class of drugs, calcitonin gene-related peptide (CGRP) antagonists, has been approved for the prevention of migraine in adults. In contrast, effective first-line therapies for mild to moderate migraine are over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs) and combination analgesics containing paracetamol, aspirin and caffeine. Keywords: acute migraine attack, migraine treatment, migraine headache, headach

Irritable bowel syndrome - pathophysiology, diagnosis, treatment. The role of low FODMAP diet

Introduction: The gut microbiota is the microorganisms in the digestive tract. They are mainly bacteria. They play a very important role in maintaining the body's homeostasis. The state of the microbiota is influenced by lifestyle including diet, stress and physical activity. In irritable bowel syndrome, there are disorders in the composition of the intestinal microbiota. It is also associated with a disruption in the proper functioning of the gut-brain axis.     Aim: The aim of this study was to review the literature reports on irritable bowel syndrome and the impact of a low FODMAP diet. Methods:  Data for the article were retrieved using PubMed setting the time descriptors to 2017-2021. Results and conclusions: Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disease. It is manifested by chronic abdominal pain , diarrhea or constipation and changes in the frequency of bowel movements. It significantly affects the quality of life of patients. The diagnosis uses the Roman IV criteria. Pharmacological as well as non-pharmacological methods are important in the treatment. A low-FODMAP diet plays a major role. Studies show that its proper use significantly alleviates the symptoms of IBS

PCOS as a generational disease - risks to mother and children

INTRODUCTION: Polycystic ovary syndrome (PCOS) is the dominant endocrine and metabolic disorder in young women. The incidence has increased significantly over the years and now affects approximately 6-20% of women of childbearing age. AIM: The aim of the work is to present the current state of knowledge about PCOS, to show what complications it brings and to present the disease as a multi-generational problem. TECHNICAL CONDITION. DESCRIPTION: It is widely accepted that hyperandrogenism plays a fundamental role in the development of most of the reproductive and metabolic disorders associated with PCOS. Excess androgens have a detrimental effect on the metabolic homeostasis of women with PCOS, acting on various metabolic tissues. PCOS is associated with reduced fertility or infertility. Women should be aware of factors affecting fertility, especially the effects of obesity and age. After pregnancy, women with PCOS have a significantly increased risk of pregnancy-related complications, including gestational diabetes, high blood pressure disorders, preterm and caesarean delivery, and pre-eclampsia.The offspring of women with PCOS may have an increased risk of birth defects and hospitalization in childhood. According to the DOHaD theory, the unfavorable uterine environment caused by mothers with PCOS, consisting in changes in fetal metabolism, may increase the susceptibility of the offspring to diseases in adulthood, according to the DOHaD theory. In addition, the offspring of PCOS are prone to a range of metabolic diseases in early adulthood, which will also affect the health of their children. CONCLUSION: The effects of endocrine disorders affect women with PCOS as well as their offspring. Diet, weight maintenance, physical activity, anti-androgenic drugs and metformin are recommended to reduce symptoms in mothers and their children. Breaking the vicious circle of intergenerational transmission remains a huge challenge

Hair loss following COVID-19 infection - the state of current knowledge and treatment approaches.

Introduction: Telogen effluvium is a non-scarring hair loss that can occur after COVID-19 infection. It usually occurs after about 3 months, causes diffused hair loss and lasts up to 6 months. The purpose of this narrative review is to collect and summarize the effects of potential methods to promote hair regrowth in patients after COVID-19 infection. Material and method: The article reviews available in PubMed and ResearchGate databases, studies on telogen effluvium and SARS-CoV-2. Due to the limited literature, articles on telogenetic hair loss progressing independently of COVID-19 were also included in the review. Results:  Hair loss after COVID-19 infection occurs in almost 30% of patients. This is likely related to pro-inflammatory cytokines released during infection and the pro-thrombotic effect of the virus. Telogen effluvium is the most common type of alopecia occurring after COIVD-19 infection - about 86% of all cases. It affects women more often than men.  It seems that its severity may correlate with the severity of the infection. Other than female gender and a history of chronic disease, it is unlikely to find any other contributing factors. Effective treatments seem to include the use of oral supplements such as vitamin D, polyunsaturated fatty acids and zinc. In addition, topical application of minoxidil and high-platelet plasma treatments have shown good outcomes. Conclusions:  Given the fairly common occurrence of hair loss after COVID-19 infection, it seems reasonable to seek the most effective strategies for its treatment. At present, it appears that the best results are obtained by combining different treatment approaches

The role of the gut microbiota and the use of new therapies in Irritable Bowel Syndrome

Introduction: Irritable bowel syndrome is a functional disorder of the gastrointestinal tract with a multifactorial nature of the disease. IBS affects 11% of the population, with the gut microbiota playing an important role in the pathophysiology. Purpose: The aim of this article is to present the course of irritable bowel syndrome, the role of the gut microbiota in pathophysiology, and new therapeutic approaches, including probiotics, based on the current state of knowledge. Conclusions: IBS is a syndrome whose exact pathophysiology is not fully understood. The state of the gut microbiota has a huge impact on the course of the disease, but also on the functioning of the whole body. New therapies currently in use, i.e. probiotics, are showing promising results, but more research is needed to find the golden mean to treat the disease. Methods: Data for the article were retrieved using PubMed setting the time descriptors to 2013-2023. Irritable bowel syndrome is one of the more common functional disorders of the gastrointestinal tract. It manifests as recurrent abdominal pain, discomfort and bloating accompanied by bowel movements without a direct underlying cause. From multicentre clinical studies, it is known that disorders of various mechanisms within the brain-gut axis, altered gastrointestinal motility and visceral hypersensitivity are the underlying causes. In addition, many scholars are of the opinion that disturbances in the gut microbiota play a key role in the pathogenesis of IBS

What do we know about rosacea? - pathophysiology and treatment

Introduction: rosacea affects approximately 10% of the world's population. It is a recurrent, inflammatory dermatosis that is difficult to deal with despite treatment. Material and methods: literature review from PubMed databases from 2017-2022. Conclusions: It is very difficult to find the cause of acne lesions. What is certain is that various factors overlap: genetic, environmental, immunological disorders, intestinal abnormalities, dietary factors. New treatments are constantly being sought. The overall health of the organism is very important in maintaining the proper function of every organ, but also of the skin - as a barrier against rosacea

Conventional and unconventional treatments for migraine

Migraine is one of the leading causes of disability in humans. It causes significant deterioration in patients' lives and prevents daily functioning. Its main symptoms include photophobia, an enormous stabbing headache, nausea and vomiting. In addition, it can be accompanied by tinnitus, visual disturbances or dizziness. Before diagnosing migraine, serious intracranial pathology or other neurological conditions should be ruled out. Treatment of acute migraine is difficult due to significant rates of nonresponse to medications and the difficulty in predicting individual response to a particular agent or dose. A new class of drugs, calcitonin gene-related peptide (CGRP) antagonists, has been approved for the prevention of migraine in adults. In contrast, effective first-line therapies for mild to moderate migraine are over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs) and combination analgesics containing paracetamol, aspirin and caffeine

Hashimoto's disease - the role of factors and diet in the course of the disease

Introduction: Hashimoto's disease is an autoimmune disorder that develops as a result of a pathological reaction of the patient's immune system, which consequently destroys the body's own healthy cells and tissues. Genetic, environmental and immunological factors influence its development. The disease may initially be asymptomatic. The exact aetiology of the disease is unknown. The worldwide incidence is approximately 10-12%. Purpose: This paper aims to present the influence of genetic factors, environmental factors, trace elements, and diet on the development and course of Hashimoto's disease based on the current state of knowledge. Conclusions: Hashimoto's disease is a multifactorial disease, but the relevance of all factors presented in the development and progression has not yet been confirmed. To date, a special diet for patients has not been created. Further research is needed to better understand the pathogenesis of the disease in order to help patients control HT. Methods: Data for the article were retrieved using PubMed setting the time descriptors to 2013-2023