Output Volatility in Emerging Market and Developing Countries: What Explains the “Great Moderation” of 1970-2003?

Output volatility and the size of output drops have declined across groups of nontransition countries studied in this paper over the past three decades, but have remained considerably higher in developing countries than in industrial countries. The paper employs a Bayesian latent dynamic factor model to decompose output growth into global, regional, and country-specific components. The favorable trends in output volatility and large output drops in developing countries are found to have resulted from lower country-specific volatility and more benign country-specific events. Evidence from cross-section regressions over the 1970–2003 period suggests that the volatility of discretionary fiscal spending and terms of trade volatility together with exchange rate flexibility were key determinants of volatility and large output drops.output volatility, output drops, fiscal policy, exchange rate policy, developing countries

Conditions for inflation in an initially inhomogeneous universe

Using a long wavelength iteration scheme to solve Einstein's equations near the Big-Bang singularity of a universe driven by a massive scalar field, we find how big initial quasi-isotropic inhomogeneities can be before they can prevent inflation to set in.Comment: 9 pages, plain Tex, gr-qc/yymmnn

String-Dominated Cosmology

If string theory controls physics at the string scale, the dynamics of the early universe before the GUT era will be governed by the low-energy string equations of motion. Studying these equations for FRW spacetimes, we find that depending on the initial conditions when the stringy era starts, and on the time when it ends, there are a wide variety of qualitatively distinct types of evolution. We classify these, and present the general solution to the equations of motion

Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils

Metabolism of arachidonic acid by cyclooxygenase is one of the primary sources of reactive oxygen species in the ischemic brain. Neuronal overexpression of cyclooxygenase-2 has recently been shown to contribute to neurodegeneration following ischemic injury. In the present study, we examined the possibility that the neuroprotective effects of the cyclooxygenase-2 inhibitor nimesulide would depend upon reduction of oxidative stress following cerebral ischemia. Gerbils were subjected to 5 min of transient global cerebral ischemia followed by 48 h of reperfusion and markers of oxidative stress were measured in hippocampus of gerbils receiving vehicle or nimesulide treatment at three different clinically relevant doses (3, 6 or 12 mg/kg). Compared with vehicle, nimesulide significantly (P<0.05) reduced hippocampal glutathione depletion and lipid peroxidation, as assessed by the levels of malondialdehyde (MDA), 4-hydroxy-alkenals (4-HDA) and lipid hydroperoxides levels, even when the treatment was delayed until 6 h after ischemia. Biochemical evidences of nimesulide neuroprotection were supported by histofluorescence findings using the novel marker of neuronal degeneration Fluoro-Jade B. Few Fluoro-Jade B positive cells were seen in CA1 region of hippocampus in ischemic animals treated with nimesulide compared with vehicle. These results suggest that nimesulide may protect neurons by attenuating oxidative stress and reperfusion injury following the ischemic insult with a wide therapeutic window of protection

Growth, physiological processes and yield of tomatoes grown in different root zone volumes using sand culture

The effects of different root zone volumes (2000, 4000 and 6000 cm3) an growth, water relations, stomatal responses, photosynthetic rate, mineral nutrition and yield of tomatoes (Lycopersicon esculentum Mill.) grown in sand culture were investigated. The plants were sampled for growth analysis fortnightly for a 56-day period. Leaf growth, stem and root dry weights were significanlty reduced with root zane volumes of 2000 and 4000 cm3. Total fruit fresh weight was reduced when plants were grown with decreasing root z.one volumes. Root zone volumes, however, did not produce a significant effect an percentage of fruit dry matter and total soluble solids. The reduction in plant growth and development was associated with reduction in water potential, photosynthetic rate and mineral nutrient uptake when plants were grown in root zone volumes of 4000 cm3 or less

CARDIOVASCULAR RISK SCREENING SERVICES IN SUDANESE COMMUNITY PHARMACIES

Objectives: The objective of this study was to investigate the Sudanese community pharmacists' knowledge and practice of cardiovascular disease risk assessment services.Methods: The study was conducted as a non-interventional, descriptive, cross sectional community-pharmacy based survey.Results: The Response rate was 91%. The obese and the elderly received the highest ratings for cardiovascular disease risk assessment. Hypertension, type 1 and type 2 diabetes mellitus and ages &gt;55 and 36-55 years were mostly targeted for screening. Variable responses were reported regarding the type of fasting lipid profile that is screened. One third of the participants claimed to have screening evaluation forms. Most participants had the appropriate equipment for screening but only a few had cholesterol measures. Only 27% reported the use of cardiovascular risk charts or calculator for the evaluation. Overwhelming majority had no documentation records and the most available reference was the BNF.Conclusion: The current knowledge and practice of cardiovascular disease risk assessment is poor and need fundamental development. Community pharmacy practice in the Sudan is still product oriented. These services were provided by respondents on voluntary bases without full knowledge or appropriate training on proper assessment and evaluation of the risks that they measured. This needs to change if pharmacy's potential is to be reached. Collaboration between health authorities and universities is essential to acknowledge the new roles of the pharmacist and provide the appropriate knowledge and training needed to promote and implement the change process that is required

A Comment on Junction and Energy Conditions in Thin Shells

This comment contains a suggestion for a slight modification of Israel's covariant formulation of junction conditions between two spacetimes, placing both sides on equal footing with normals having uniquely defined orientations. The signs of mass energy densities in thin shells at the junction depend not only on the orientations of the normals and it is useful therefore to discuss the sign separately. Calculations gain in clarity by not choosing the orientations in advance. Simple examples illustrate our point and complete previous classifications of spherical thin shells in spherically symmetric spacetimes relevant to cosmology.Comment: (Tex file + PS file with a figure) Tex errors were correcte

Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia

Cyclooxygenase-2 is involved in the inflammatory component of the ischemic cascade, playing an important role in the delayed progression of the brain damage. The present study evaluated the pharmacological effects of the selective cyclooxygenase-2 inhibitor nimesulide on delayed neuronal death of hippocampal CA1 neurons following transient global cerebral ischemia in gerbils. Administration of therapeutically relevant doses of nimesulide (3, 6 and 12 mg/kg; i.p.) 30 min before ischemia and at 6, 12, 24, 48 and 72 h after ischemia significantly (P<0.01) reduced hippocampal neuronal damage. Treatment with a single dose of nimesulide given 30 min before ischemia also resulted in a significant increase in the number of healthy neurons in the hippocampal CA1 sector 7 days after ischemia. Of interest is the finding that nimesulide rescued CA1 pyramidal neurons from ischemic death even when treatment was delayed until 24 h after ischemia (34+/-9% protection). Neuroprotective effect of nimesulide is still evident 30 days after the ischemic episode, providing the first experimental evidence that cyclooxygenase-2 inhibitors confer a long-lasting neuroprotection. Oral administration of nimesulide was also able to significantly reduce brain damage, suggesting that protective effects are independent of the route of administration. The present study confirms the ability of cyclooxygenase-2 inhibitors to reduce brain damage induced by cerebral ischemia and indicates that nimesulide can provide protection when administered for up to 24 h post-ischemia

Experiences and perspectives of adults on using opioids for pain management in the postoperative period : A scoping review protocol.

Funding The main reviewer (DA) is funded by Prince Sultan Military College of Health Sciences, Dhahran, Saudi Arabia and the Saudi Arabian Cultural Bureau in London, UK. This review will be part of DA’s PhD study at the University of Aberdeen.Peer reviewedPublisher PD