Modeling and dynamic analysis of rotating composite shaft

Structural modeling and dynamical analysis of rotating composite shaft are conducted in this paper. A thin-walled composite shaft structure model, which includes the transverse shear deformation of the shaft, rigid disks and the flexible bearings, is presented and then used to predict natural frequencies and dynamical stability. Based on the thin-walled composite beam theory referred to as variational asymptotically method (VAM), the displacement and strain fields of the shaft are described. Hamilton’s principle is employed to derive the equations of motion of the shaft system. Galerkin’s method is used to discretize and solve the governing equations. The validity of the model is proved by comparing the results with those in literatures and convergence examination. The effects of fiber orientation, ratios of length over radius, ratios of radius over thickness and shear deformation on natural frequency and critical speeds are investigated. Finally the unbalance transient responses of the composite shaft system are also given by using the time-integration method

Primary resonance of a rotating composite shaft with geometrical nonlineary

The primary resonance of a simply supported rotating composite shafts with geometrical nonlineary is studied. The composite shaft is modeled as a thin-walled Euler-Bernoulli beam. A variational-asymptotical method (VAM) applied to anisotropic thin-walled closed-cross-sectional beams is used to describe the displacement and strain fields of the composite shafts. The geometrical nonlineary is considered in the relationships of strain and displacement of the shaft. The nonlinear extensional-bending-torsional equations of motion for the composite shaft are derived by using the Hamilton principle. In order to emphatically study nonlinear transverse bending vibration, the effects of extensional and torsional deformations are ignored. By means of the method of multiple scales the approximation solution of primary resonance of transverse bending vibration is obtained. The Galerkin method is employed to reduce the governing equations to the ordinary differential equations. By using fourth-order Runge-Kutta method the time histories, phase diagrams and power spectrums are plotted. The study shows the effect of the external damping, ply angle, eccentricity, ratios of length over radius, ratios of radius over thickness and rotating speed on nonlinear dynamic behavior of the shaft. Specifically, the numerical simulation results show that the shaft exhibits the complex dynamic behavior including periodic, quasi-periodic and chaotic motion

Modeling and Dynamical Behavior of Rotating Composite Shafts with SMA Wires

A dynamical model is developed for the rotating composite shaft with shape-memory alloy (SMA) wires embedded in. The rotating shaft is represented as a thin-walled composite of circular cross-section with SMA wires embedded parallel to shaft’s longitudinal axis. A thermomechanical constitutive equation of SMA proposed by Brinson is employed and the recovery stress of the constrained SMA wires is derived. The equations of motion are derived based on the variational-asymptotical method (VAM) and Hamilton’s principle. The partial differential equations of motion are reduced to the ordinary differential equations of motion by using the Galerkin method. The model incorporates the transverse shear, rotary inertia, and anisotropy of composite material. Numerical results of natural frequencies and critical speeds are obtained. It is shown that the natural frequencies of the nonrotating shaft and the critical rotating speed increase as SMA wire fraction and initial strain increase and the increase in natural frequencies becomes more significant as SMA wire fraction increases. The initial strain of SMA wires appears to have marginal effect on dynamical behaviors of the shaft. The actuation performance of SMA wires is found to be closely related to the ply-angle

ACY1 Downregulation Enhances the Radiosensitivity of Cetuximab-Resistant Colorectal Cancer by Inactivating the Wnt/β-Catenin Signaling Pathway

Treatment of cetuximab-resistant colorectal cancer (CRC) is a global healthcare problem. This study aimed to assess the effects of radiotherapy on cetuximab-resistant CRC and explore the underlying mechanism. We established a cetuximab-resistant HCT116 cell line (HCT116-R) by extracorporeal shock. Differentially expressed mRNAs were screened from cells treated with different radiation doses using second-generation high-throughput sequencing. Sequence data showed that ACY1 was significantly downregulated in HCT116-R cells after irradiation. Analysis of the GEO and TCGA datasets revealed that high ACY1 expression was associated with lymph node metastasis and a poor prognosis in CRC patients. In addition, immunohistochemistry results from CRC patients revealed that ACY1 protein expression was related to cetuximab resistance and lymph node metastasis. These findings suggested that ACY1 may function as an oncogene to promote CRC progression and regulate the radiosensitivity of cetuximab-resistant CRC. As expected, ACY1 silencing weakened the proliferation, migration, and invasion abilities of HCT116-R cells after radiotherapy. Mechanistically, TCGA data demonstrated that ACY1 expression was closely related to the Wnt/β-catenin pathway in CRC. We validated that radiotherapy first reduced β-catenin levels, followed by decreased expression of the metastasis-related protein E-cadherin. Silencing ACY1 dramatically enhanced these changes in β-catenin and E-cadherin after radiotherapy. In conclusion, ACY1 downregulation could enhance the radiosensitivity of cetuximab-resistant CRC by inactivating Wnt/β-catenin signaling, implying that ACY1 may serve as a radiotherapy target for cetuximab-resistant CRC

Self-Powered Human-Interactive Transparent Nanopaper Systems

Self-powered human-interactive but invisible electronics have many applications in anti-theft and anti-fake systems for human society. In this work, for the first time, we demonstrate a transparent paper-based, self-powered, and human-interactive flexible system. The system is based on an electrostatic induction mechanism with no extra power system appended. The self-powered, transparent paper device can be used for a transparent paper-based art anti-theft system in museums or for a smart mapping anti-fake system in precious packaging and documents, by virtue of the advantages of adding/removing freely, having no impairment on the appearance of the protected objects, and being easily mass manufactured. This initial study bridges the transparent nanopaper with a self-powered and human-interactive electronic system, paving the way for the development of smart transparent paper electronics