Stabilizing the spiral order with spin-orbit coupling in an anisotropic triangular antiferromagnet

We study the effects of spin-orbit coupling (SOC) on the large-U Hubbard model on anisotropic triangular lattice at half-filling using the Schwinger-boson method. We find that the SOC will in general lead to a zero temperature condensation of the Schwinger bosons with a single condensation momentum. As a consequence, the spin-spin correlation vanishes along the z-axis but develops in the $x$-$y$ plane, with the ordering wave vector being dramatically dependent on the SOC. Moreover, the phase boundary of the magnetic ordered state extends to the region of large spatial anisotropy with increased condensation density, demonstrating that the spiral order is always stabilized by the SOC.Comment: 4 pages, 4figure

STUB1 suppresseses tumorigenesis and chemoresistance through antagonizing YAP1 signaling

Yes-associated protein (YAP) is a component of the canonical Hippo signaling pathway that is known to play essential roles in modulating organ size, development, and tumorigenesis. Activation or upregulation of YAP1, which contributes to cancer cell survival and chemoresistance, has been verified in different types of human cancers. However, the molecular mechanism of YAP1 upregulation in cancer is still unclear. Here we report that the E3 ubiquitin ligase STUB1 ubiquitinates and destabilizes YAP1, thereby inhibiting cancer cell survival. Low levels of STUB1 expression were correlated with increased protein levels of YAP1 in human gastric cancer cell lines and patient samples. Moreover, we revealed that STUB1 ubiquitinates YAP1 at the K280 site by K48-linked polyubiquitination, which in turn increases YAP1 turnover and promotes cellular chemosensitivity. Overall, our study establishes YAP1 ubiquitination and degradation mediated by the E3 ligase STUB1 as an important regulatory mechanism in gastric cancer, and provides a rationale for potential therapeutic interventions

PROV-IO+: A Cross-Platform Provenance Framework for Scientific Data on HPC Systems

Data provenance, or data lineage, describes the life cycle of data. In scientific workflows on HPC systems, scientists often seek diverse provenance (e.g., origins of data products, usage patterns of datasets). Unfortunately, existing provenance solutions cannot address the challenges due to their incompatible provenance models and/or system implementations. In this paper, we analyze four representative scientific workflows in collaboration with the domain scientists to identify concrete provenance needs. Based on the first-hand analysis, we propose a provenance framework called PROV-IO+, which includes an I/O-centric provenance model for describing scientific data and the associated I/O operations and environments precisely. Moreover, we build a prototype of PROV-IO+ to enable end-to-end provenance support on real HPC systems with little manual effort. The PROV-IO+ framework can support both containerized and non-containerized workflows on different HPC platforms with flexibility in selecting various classes of provenance. Our experiments with realistic workflows show that PROV-IO+ can address the provenance needs of the domain scientists effectively with reasonable performance (e.g., less than 3.5% tracking overhead for most experiments). Moreover, PROV-IO+ outperforms a state-of-the-art system (i.e., ProvLake) in our experiments

Percutaneous closure of postinfarct muscular ventricular septal defects: A multicenter study in China

AbstractBackgroundSurgical repair is an effective method to treat ventricular septal defect (VSD) complicating acute myocardial infarction (AMI). However, the mortality rate remains high. This study was designed to assess the immediate and mid-term results of transcatheter closure of postinfarct muscular VSDs.MethodsData were retrospectively collected from 42 AMI patients who underwent attempted transcatheter VSD closure between 2008 and 2012 in seven heart centers of China.ResultsNine patients underwent emergent VSD closure in the acute phase (within two weeks from VSD) while the others underwent elective closure. The time between VSD occurrence and closure in emergency group and elective group was 7.7±2.3 days and 35±14.5 days, respectively (p<0.01). The percentage of procedure success in the emergency group and elective group was 77.8% (7/9) and 97% (32/33), respectively (p=0.048). The hospital mortality was higher for emergent closure in comparison to elective closure (66.7% vs. 6.1%, p<0.01). During a median follow-up of 25 months (0–58 months), two patients died at 8 and 29 months, respectively, and no serious complications occurred in other patients.ConclusionInterventional postinfarct VSD closure is a safe and effective approach that can be performed with a high procedural success rate, with favorable outcomes if it can be undertaken >14 days postinfarct

Bioactive compounds from Rumex plants

Two new naphthalene acylglucosides, rumexneposides A (1) and B (2), together with 12 known compounds (3-14), were isolated from the roots of Rumex nepalensis. Their structures were established by chemical and spectroscopic methods. The biological activities of compounds 1-14 as well as an additional 11 compounds previously isolated from R. nepalensis and Rumex hastatus (15–25) were evaluated against Mycobacterium tuberculosis, para-aminobenzoic acid (pAba) pathway, and a panel of human cancer cell lines. The results showed that compound 15 was the most active against M. tuberculosis with an MIC value of 2.85 mM similar to that of isoniazid. Compound 5 could inhibit pAba synthetic pathway with an MIC value of 12.6 mM, comparable to that of positive control abyssomicin C, representing a new example of the rare pAba pathway inhibitors

Distribution of nucleosides in populations of Cordyceps cicadae

A rapid HPLC method had been developed and used for the simultaneous determination of 10 nucleosides (uracil, uridine, 2'-deoxyuridine, inosine, guanosine, thymidine, adenine, adenosine, 2'-deoxyadenosine and cordycepin) in 10 populations of Cordyceps cicadae, in order to compare four populations of Ophicordyceps sinensis and one population of Cordyceps militaris. Statistical analysis system (SAS) 8.1 was used to analyze the nucleoside data. The pattern of nucleoside distribution was analyzed in the sampled populations of C. cicadae, O. sinensis and C. militaris, using descriptive statistical analysis, nested analysis and Q cluster analysis. The total amount of the 10 nucleosides in coremium was 1,463.89-5,678.21 mu g/g in 10 populations of C. cicadae, 1,369.80-3,941.64 mu g/g in sclerotium. The average contents of the 10 analytes were 4,392.37 mu g/g and 3,016.06 mu/g in coremium and sclerotium, respectively. The coefficient of variation (CV) of nucleosides ranged from 8.36% to 112.36% in coremium of C. cicadae, and from 10.77% to 155.87% in sclerotium of C. cicadae. The CV of the nucleosides was wide within C. cicadae populations. The nested variation analysis by the nine nucleosides' distribution indicated that about 42.29% of the nucleoside variability in coremium was attributable to the differentiation among populations, and the remaining 57.71% resided in the populations. It was also shown that about 28.94% of the variation in sclerotium was expressed between populations, while most of the variation (71.06%) corresponded to the populations