Two new naphthalene acylglucosides, rumexneposides A (1) and B (2), together with 12 known
compounds (3-14), were isolated from the roots of Rumex nepalensis. Their structures were established
by chemical and spectroscopic methods. The biological activities of compounds 1-14 as well as an
additional 11 compounds previously isolated from R. nepalensis and Rumex hastatus (15–25) were
evaluated against Mycobacterium tuberculosis, para-aminobenzoic acid (pAba) pathway, and a panel of
human cancer cell lines. The results showed that compound 15 was the most active against M.
tuberculosis with an MIC value of 2.85 mM similar to that of isoniazid. Compound 5 could inhibit pAba
synthetic pathway with an MIC value of 12.6 mM, comparable to that of positive control abyssomicin C,
representing a new example of the rare pAba pathway inhibitors
