3-(1H-Tetra­zol-5-yl)pyridinium chloride

In the cation of the title compound, C6H6N5 +·Cl−, the pyridinium and tetra­zole rings are nearly coplanar, making a dihedral angle of 5.05 (12)°. The cations and anions are connected by inter­molecular N—H⋯Cl hydrogen bonds, forming a centrosymmetric [2 + 2] aggregate. The aggregates are stacked along the a axis

HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N6-methyladenosine.

Small-molecule inhibitors for the 90-kDa heat shock protein (HSP90) have been extensively exploited in preclinical studies for the therapeutic interventions of human diseases accompanied with proteotoxic stress. By using an unbiased quantitative proteomic method, we uncover that treatment with three HSP90 inhibitors results in elevated expression of a large number of heat shock proteins. We also demonstrate that the HSP90 inhibitor-mediated increase in expression of DNAJB4 protein occurs partly through an epitranscriptomic mechanism, and is substantially modulated by the writer, eraser, and reader proteins of N6-methyladenosine (m6A). Furthermore, exposure to ganetespib leads to elevated modification levels at m6A motif sites in the 5'-UTR of DNAJB4 mRNA, and the methylation at adenosine 114 site in the 5'-UTR promotes the translation of the reporter gene mRNA. This m6A-mediated mechanism is also at play upon heat shock treatment. Cumulatively, we unveil that HSP90 inhibitors stimulate the translation of DNAJB4 through an epitranscriptomic mechanism

An Augmented Subspace Based Adaptive Proper Orthogonal Decomposition Method for Time Dependent Partial Differential Equations

In this paper, we propose an augmented subspace based adaptive proper orthogonal decomposition (POD) method for solving the time dependent partial differential equations. By augmenting the POD subspace with some auxiliary modes, we obtain an augmented subspace. We use the difference between the approximation obtained in this augmented subspace and that obtained in the original POD subspace to construct an error indicator, by which we obtain a general framework for augmented subspace based adaptive POD method. We then provide two strategies to obtain some specific augmented subspaces, the random vector based augmented subspace and the coarse-grid approximations based augmented subspace. We apply our new method to two typical 3D advection-diffusion equations with the advection being the Kolmogorov flow and the ABC flow. Numerical results show that our method is more efficient than the existing adaptive POD methods, especially for the advection dominated models.Comment: 28 pages, 4 figures, 7 table

Transition from Offline to Online through Digital Resource Bricolage in A Health Crisis: A Case Study of Two Primary Schools

Background: Health crisis responses underline maintaining normal operations. By utilizing digital resources, organizations are able to maintain essential operations through transiting their operations from offline to online during a health crisis. However, little is known about how organizations rapidly adapt to online operations. By taking resource bricolage as the theoretical lens, this study investigates the process that organizations rapidly transit from offline to online through digital resource bricolage during health crises. Methods: A case study of two primary schools that maintained operations during COVID-19 was conducted, with a focus on the utilization of digital resources and resource bricolage. Secondary data collection, interviews and coding strategy were utilized to collect and analyze data to reveal the process that organizations rapidly transit from offline to online through digital resource bricolage. Results: The findings reveal a sequential three-step resource bricolage process, including redeploying digital resource functions, combining digital and non-digital resources, and coordinating interaction among participants, as well as the corresponding resource bricolage behaviors and domains. Conclusions: This study contributes to information systems (IS) studies on crisis responses by identifying the sequential steps of digital resource bricolage to transit from offline to online during health crises. In addition, this study contributes to the development of resource bricolage perspectives by identifying new resource bricolage actions that suitable for the health crisis response

Human and Machine Speaker Recognition Based on Short Trivial Events

Trivial events are ubiquitous in human to human conversations, e.g., cough, laugh and sniff. Compared to regular speech, these trivial events are usually short and unclear, thus generally regarded as not speaker discriminative and so are largely ignored by present speaker recognition research. However, these trivial events are highly valuable in some particular circumstances such as forensic examination, as they are less subjected to intentional change, so can be used to discover the genuine speaker from disguised speech. In this paper, we collect a trivial event speech database that involves 75 speakers and 6 types of events, and report preliminary speaker recognition results on this database, by both human listeners and machines. Particularly, the deep feature learning technique recently proposed by our group is utilized to analyze and recognize the trivial events, which leads to acceptable equal error rates (EERs) despite the extremely short durations (0.2-0.5 seconds) of these events. Comparing different types of events, 'hmm' seems more speaker discriminative.Comment: ICASSP 201

消化内科护理风险及管理对策分析

Objective: To explore the common nursing risk in department of gastroenterology and clinical nursing management strategies, in order to provide the basis for nursing in the department of gastroenterology. Methods: Analyze and discuss of the common characteristics of nursing risk in our hospital department of gastroenterology, and summarize the countermeasure and method of correlation of risk management. The implementation of risk management as the observation group and the other as the control group, and clinical nursing effect between the two groups would be compared. Moreover, nursing ability improvement circumstance for the nursing staff was compared before and after the implementation of risk management. Results: The observation group after the risk management of nursing errors, medical disputes and the patients' satisfaction were better than the control group, there is statistical significance (P< 0.05). After the risk management in Department of gastroenterology, nursing work of nursing staff in various digestive operation is proficient, medical record documents writing norms, communication ability, the emergency ability is superior before the implementation of risk management, there is statistical significance (P<0.05). Conclusion: In the nursing management in the Department of gastroenterology, the implementation of risk management is helpful to improve the ability of nursing and the nursing quality, reduce nursing risk in Department of gastroenterology, and improve hospital patient satisfaction.目的  探讨消化内科中常见的护理风险以及临床护理管理对策，为消化内科的安全护理提供依据。方法  对本院消化内科常见的护理风险特点进行分析讨论，总结相关风险管理的对策与方法。将未实施风险管理作为对照组，实施风险管理为观察组，比较两组临床护理效果，并对护理人员实施风险管理前、后护理能力改善情况进行对比研究。结果  观察组实施风险管理后护理差错、医疗纠纷以及患者护理满意度方面均优于对照组，比较差异有显著性（P<0.05），具有统计学意义。实施风险管理后护理人员对消化内科各种护理工作操作熟练程度，病历文书书写规范性，沟通能力，应急能力等方面均优于实施风险管理前，比较差异有显著性（P<0.05），具有统计学意义。结论  在消化内科的护理管理中，实施风险管理有助于提高护理能力和护理质量，降低消化内科的护理风险，提高患者的满意度

Truncated atomic plane wave method for the subband structure calculations of Moir\'e systems

We propose a highly efficient and accurate numerical scheme named Truncated Atomic Plane Wave (TAPW) method to determine the subband structure of Twisted Bilayer Graphene (TBG) inspired by BM model. Our method utilizes real space information of carbon atoms in the moir\'e unit cell and projects the full tight binding Hamiltonian into a much smaller subspace using atomic plane waves. We present accurate electronic band structures of TBG in a wide range of twist angles together with detailed moir\'e potential and screened Coulomb interaction at the first magic angle using our new method. Furthermore, we generalize our formalism to solve the problem of low frequency moir\'e phonons in TBG

Weathering, shock metamorphism and type distribution patterns of 98 ordinary chondrites from the Grove Mountains, Antarctica

Petrography and mineral chemistry of ninety-eight ordinary chondrites from Grove Mountains (GRV), Antarctica, were presented and their. Weathering effect, shock metamorphism and type distribution patterns were discussed in this study. Among them, six are unequilibrated ordinary chondrites, including 3H3 and 3 L3; and 92 meteorites are equilibrated ordinary chondrites, including 24H-group (13H4, 10 H5, 1H6), 64 L-group (2 L4, 44 L5, 18 L6) and 4 LL-group (3 LL4, 1 LL5). Most GRV chondrites ( > 90% ) displayed minor weathering effect (W1 and W2). About half of the meteorites experienced severe shock metamorphism. They commonly contain shock-induced melt veins and pockets. These heavily shocked meteorites provide us with natural samples for study of high-pressure polymorphs of minerals. In addition, the Grove Mountains collection seems to have more abundant unequilibrated and L group ordinary chondrites compared to the US Antarctic meteorite collection which were mainly found a long the Transantarctic Mountains