137 research outputs found
Anti-inflammatory Activity of the Plant Cannabis sativa (L) Petrolium Ether Extract in Albino Rats
In this study the plant Cannabis sativa seeds petroleum oil extract was investigated for anti- inflammatory activity on albino rats. The inflammation was firstly obtained by using carrageenan suspension 0.1 ml of 10% saline injected at the sub – plantar region of the left limb for inducing a local acute oedema. A decreased in oedema size was reported after 24 hours for the rats pretreated with carrageenan30 minutes before injection with suspension( 4.56, 0.59 and 0.93 for control, 1ml/kg per day and 0.5ml/kg per day groups given C. sativa seed extracts respectively.), compared to Indomethacin standard antiinflammatory drug which reported a decrease in oedema size diameter to 0.55mm, which indicated an increase inhibition percentages were reported for the different pretreated groups 0.00, 87.03, 79.56 and 87.91 including the comparative Indomethacin treated groups of rats respectively. On the other hand, the post-treated groups of rats (given C. sativa oil extract after 30 minutes of injection of suspension) showed a similar results for maximum concentration 1 ml/day of C. sativa oil extract in comparison to the standard drug. Hence, such results recommend the prospect focus for the preventive medication use of the extract. The study also highlights no significant changes for serum and protein of the blood taken from rats of the experiments. Although there were significant decrease in lymphocyte and neutrophil, but the changes were not significant. Indomethacin was given to the rats used for a comparative drug (10mg/kg). Moreover, the drug indomethacin used as a comparative parameter showed similar results in comparison to the extract, hence wise the reported results may be recommended for use as anti-inflammatory agent and should be explored more to formulate drug on basis of its activity
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An evidence review of research on health interventions in humanitarian crises
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Cataclysmic Variables from Sloan Digital Sky Survey. VI. The Sixth Year (2005)
The 28 cataclysmic variables (CVs) found in 2005 in the Sloan Digital Sky Survey are presented with their coordinates, magnitudes, and spectra. Five of these systems are previously known CVs (HH Cnc, SX LMi, QZ Ser, AP CrB, and HS 1016+3412), and the rest are new discoveries. Additional spectroscopic, photometric, and/or polarimetric observations of 10 systems were carried out, resulting in estimates of the orbital periods for seven of the new binaries. The 23 new CVs include one eclipsing system, one new Polar, and five systems whose spectra clearly reveal atmospheric absorption lines from the underlying white dwarf
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Cataclysmic Variables from Sloan Digital Sky Survey. VI. The Sixth Year (2005)
The 28 cataclysmic variables (CVs) found in 2005 in the Sloan Digital Sky Survey are presented with their coordinates, magnitudes, and spectra. Five of these systems are previously known CVs (HH Cnc, SX LMi, QZ Ser, AP CrB, and HS 1016+3412), and the rest are new discoveries. Additional spectroscopic, photometric, and/or polarimetric observations of 10 systems were carried out, resulting in estimates of the orbital periods for seven of the new binaries. The 23 new CVs include one eclipsing system, one new Polar, and five systems whose spectra clearly reveal atmospheric absorption lines from the underlying white dwarf
Inflation and late time acceleration in braneworld cosmological models with varying brane tension
Braneworld models with variable brane tension introduce a new
degree of freedom that allows for evolving gravitational and cosmological
constants, the latter being a natural candidate for dark energy. We consider a
thermodynamic interpretation of the varying brane tension models, by showing
that the field equations with variable can be interpreted as
describing matter creation in a cosmological framework. The particle creation
rate is determined by the variation rate of the brane tension, as well as by
the brane-bulk energy-matter transfer rate. We investigate the effect of a
variable brane tension on the cosmological evolution of the Universe, in the
framework of a particular model in which the brane tension is an exponentially
dependent function of the scale factor. The resulting cosmology shows the
presence of an initial inflationary expansion, followed by a decelerating
phase, and by a smooth transition towards a late accelerated de Sitter type
expansion. The varying brane tension is also responsible for the generation of
the matter in the Universe (reheating period). The physical constraints on the
model parameters, resulted from the observational cosmological data, are also
investigated.Comment: 25 pages, 8 figures, accepted for publication in European Physical
Journal
Reheating the Universe in Braneworld Cosmological Models with bulk-brane energy transfer
The emergence of the cosmological composition (the reheating era) after the
inflationary period is analyzed in the framework of the braneworld models, in
which our Universe is a three-brane embedded in a five-dimensional bulk, by
assuming the possibility of the brane-bulk energy exchange. The inflaton field
is assumed to decay into normal matter only, while the dark matter is injected
into the brane from the bulk. To describe the reheating process we adopt a
phenomenological approach, by describing the decay of the inflaton field by a
friction term proportional to the energy density of the field. After the
radiation dominated epoch the model reduces to the standard four dimensional
cosmological model. The modified field equations are analyzed analytically and
numerically in both the extra-dimensions dominate reheating phase (when the
quadratic terms in energy density dominate the dynamics), and in the general
case. The evolution profiles of the matter, of the scalar field and of the
scale factor of the universe are obtained for different values of the
parameters of the model, and of the equations of state of the normal and dark
matter, respectively. The equation describing the time evolution of the ratio
of the energy density of the dark and of the normal matter is also obtained.
The ratio depends on the rate of the energy flow between the bulk and the
brane. The observational constraint of an approximately constant ratio of the
dark and of the baryonic matter requires that the dark matter must be
non-relativistic (cold). The model predicts a reheating temperature of the
order of GeV, a brane tension of the order of GeV,
and the obtained composition of the universe is consistent with the
observational data.Comment: 29 pages, 9 figures, accepted for publication in JCA
Correlates of Syphilis Seroreactivity Among Pregnant Women: The HIVNET 024 Trial in Malawi, Tanzania, and Zambia
The objectives of this cross-sectional study were to determine correlates of syphilis seroprevalence among HIV-infected and -uninfected antenatal attendees in an African multisite clinical trial, and to improve strategies for maternal syphilis prevention
In Vitro and In Silico Antioxidant Efficiency of Bio-Potent Secondary Metabolites From Different Taxa of Black Seed-Producing Plants and Their Derived Mycoendophytes
Oxidative stress is involved in the pathophysiology of multiple health complications, and it has become a major focus in targeted research fields. As known, black seeds are rich sources of bio-active compounds and widely used to promote human health due to their excellent medicinal and pharmaceutical properties. The present study investigated the antioxidant potency of various black seeds from plants and their derived mycoendophytes, and determined the total phenolic and flavonoid contents in different extracts, followed by characterization of major constituents by HPLC analysis. Finally, in silico docking determined their binding affinities to target myeloperoxidase enzymes. Ten dominant mycoendophytes were isolated from different black seed plants. Three isolates were then selected based on high antiradical potency and further identified by ITS ribosomal gene sequencing. Those isolated were Aspergillus niger TU 62, Chaetomium madrasense AUMC14830, and Rhizopus oryzae AUMC14823. Nigella sativa seeds and their corresponding endophyte A. niger had the highest content of phenolics in their n-butanol extracts (28.50 and 24.43 mg/g), flavonoids (15.02 and 11.45 mg/g), and antioxidant activities (90.48 and 81.48%), respectively, followed by Dodonaea viscosa and Portulaca oleracea along with their mycoendophytic R. oryzae and C. madrasense. Significant positive correlations were found between total phenolics, flavonoids, and the antioxidant activities of different tested extracts. The n-butanol extracts of both black seeds and their derived mycoendophytes showed reasonable IC50 values (0.81–1.44 mg/ml) compared to the control with significant correlations among their phytochemical contents. Overall, seventeen standard phenolics and flavonoids were used, and the compounds were detected in different degrees of existence and concentration in the examined extracts through HPLC analysis. Moreover, the investigation of the molecular simulation results of detected compounds against the myeloperoxidase enzyme revealed that, as a targeted antioxidant, rutin possessed a high affinity (−15.3184 kcal/mol) as an inhibitor. Taken together, the black seeds and their derived mycoendophytes are promising bio-prospects for the broad industrial sector of antioxidants with several valuable potential pharmaceutical and nutritional applications
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