Anesthetic management of laryngectomy and neck dissection surgery: Retrospective analysis [Larenjektomi ve boyun diseksiyonu operasyonlarinda anestezi yönetimi: Retrospektif analiz]

Objective: Laryngectomy and neck dissection are among the special operations in terms of anesthesia management as well as surgical application. In this retrospective study, it was aimed to evaluate the perioperative anesthesia management of the patients who underwent laryngectomy and/or neck dissection operation by the otolaryngology department and discuss. Method: A total of 44 patients between 2014 and 2017 were retrospectively evaluated. Results: The study was completed with 42 patients as all records of 2 could'nt obtained. Forty patients were male and 2 were female. Total laryngectomy+neck dissection was performed in 31 patients(73.8%), total laryngectomy+total thyroidectomy+neck dissection operation was performed in 11 patients (26.2%). Mean blood loss was 239±156 ml. No blood and blood products were transfused for 35 patients (83.3%). Four patients had 1 unit and 3 patients had 2 erythrocyte suspension units. The most common complication observed during the operation was deep hypotension with 23.8% (10 patients). Ephedrine and adrenaline were applied in the treatment of hypotension. Three patients required deep bradycardia for treatment and atropine was administered. Hypocalcemia developed in 12 patients, postoperatively. Conclusion: Laryngectomy and neck dissection operations are special operations in terms of surgery and anesthesia management and require close follow-up for possible peroperative and/or postoperative complications. © 2018 Anestezi Dergisi. All rights reserved

Evaluation of oxidative stress markers and antioxidant status in dementia and Parkinson disease

36th FEBS Congress of the Biochemistry for Tomorrows Medicine -- JUN 25-30, 2011 -- Torino, ITALYWOS: 000292333102456…Federat Soc Biochem & Mol Bio

EVALUATION OF OXIDATIVE STRESS MARKERS AND ANTIOXIDANT STATUS IN THE ALZHEIMER DISEASE, VASCULAR DEMENTIA AND THE PARKINSON DISEASE

WOS: 000318748400022Oxidative stress may be involved in pathogenesis of neurodegenerative diseases. We aimed to measure MDA, NO, 8-OHdG and TAC, SOD and CAT levels in the Alzheimer disease, Parkinson disease and vascular dementia, and evaluate oxidant and antioxidant status in these diseases. Oxidative stress parameters were measured in 20 patients with vascular dementia, 20 patients with the Alzheimer disease, 20 patients with the Parkinson disease and 20 matching controls. MDA, NO and TAC were assayed with spectrophotometric methods. 8-OHdG was quantitated by the Elisa method. SOD and CAT were assayed with colorimetric methods. MDA, NO, 8-OHdG and SOD levels in total patient group were higher (p = 0.039, 0.041, 0.021 and 0.045, respectively), while TAC levels were lower (p = 0.010) as compared with controls. When compared to controls, the following were higher: MDA in the Parkinson disease (p = 0.036); NO in the Alzheimer disease (p = 0.028). However, TAC in the Alzheimer disease (p = 0.024) were lower. We observed negative correlations between TAC and MDA in the Parkinson disease (r = -0.496, p = 0.026); between SOD and 8-OHdG in the Alzheimer disease (r = 0.526, p = 0.017). These findings support the idea that the oxidative stress may play an important role in the pathogenesis of neurodegenerative diseases. This preliminary study shows an increase in free radical production in the Alzheimer disease and Parkinson disease. Also, there is a defect in the antioxidant defense system, which may lead to oxidative damage in patients with the Alzheimer disease