837 research outputs found
Modelling the behaviour of microbulk Micromegas in Xenon/trimethylamine gas
We model the response of a state of the art micro-hole single-stage charge
amplication device (`microbulk' Micromegas) in a gaseous atmosphere consisting
of Xenon/trimethylamine at various concentrations and pressures. The amplifying
structure, made with photo-lithographic techniques similar to those followed in
the fabrication of gas electron multipliers (GEMs), consisted of a 100 um-side
equilateral-triangle pattern with 50 um-diameter holes placed at its vertexes.
Once the primary electrons are guided into the holes by virtue of an optimized
field configuration, avalanches develop along the 50 um-height channels etched
out of the original doubly copper-clad polyimide foil. In order to properly
account for the strong field gradients at the holes' entrance as well as for
the fluctuations of the avalanche process (that ultimately determine the
achievable energy resolution), we abandoned the hydrodynamic framework,
resorting to a purely microscopic description of the electron trajectories as
obtained from elementary cross-sections. We show that achieving a satisfactory
description needs additional assumptions about atom-molecule (Penning) transfer
reactions and charge recombination to be made
Improved induction of anti-melanoma T cells by adenovirus-5/3 fiber modification to target human DCs
To mount a strong anti-tumor immune response, non T cell inflamed (cold) tumors may require combination treatment encompassing vaccine strategies preceding checkpoint inhibition. In vivo targeted delivery of tumor-associated antigens (TAA) to dendritic cells (DCs), relying on the natural functions of primary DCs in situ, represents an attractive vaccination strategy. In this study we made use of a full-length MART-1 expressing C/B-chimeric adenoviral vector, consisting of the Ad5 capsid and the Ad3 knob (Ad5/3), which we previously showed to selectively transduce DCs in human skin and lymph nodes. Our data demonstrate that chimeric Ad5/3 vectors encoding TAA, and able to target human DCs in situ, can be used to efficiently induce expansion of functional tumor-specific CD8⁺ effector T cells, either from a naïve T cell pool or from previously primed T cells residing in the melanoma-draining sentinel lymph nodes (SLN). These data support the use of Ad3-knob containing viruses as vaccine vehicles for in vivo delivery. "Off-the-shelf" DC-targeted Ad vaccines encoding TAA could clearly benefit future immunotherapeutic approaches
Gaseous time projection chambers for rare event detection: Results from the T-REX project. II. Dark matter
As part of the T-REX project, a number of R&D and prototyping activities have
been carried out during the last years to explore the applicability of
Micromegas-read gaseous TPCs in rare event searches like double beta decay
(DBD), axion research and low-mass WIMP searches. While in the companion paper
we focus on DBD, in this paper we focus on the results regarding the search for
dark matter candidates, both axions and WIMPs. Small ultra-low background
Micromegas detectors are used to image the x-ray signal expected in axion
helioscopes like CAST at CERN. Background levels as low as
c keVcms have already been achieved in CAST while values
down to c keVcms have been obtained in a
test bench placed underground in the Laboratorio Subterr\'aneo de Canfranc.
Prospects to consolidate and further reduce these values down to
c keVcmswill be described. Such detectors, placed at the
focal point of x-ray telescopes in the future IAXO experiment, would allow for
10 better signal-to-noise ratio than CAST, and search for solar axions with
down to few 10 GeV, well into unexplored axion
parameter space. In addition, a scaled-up version of these TPCs, properly
shielded and placed underground, can be competitive in the search for low-mass
WIMPs. The TREX-DM prototype, with 0.300 kg of Ar at 10 bar, or
alternatively 0.160 kg of Ne at 10 bar, and energy threshold well below 1
keV, has been built to test this concept. We will describe the main technical
solutions developed, as well as the results from the commissioning phase on
surface. The anticipated sensitivity of this technique might reach
cm for low mass ( GeV) WIMPs, well beyond current
experimental limits in this mass range.Comment: Published in JCAP. New version with erratum incorporated (new figure
14
TREX-DM: a low background Micromegas-based TPC for low mass WIMP detection
Dark Matter experiments are recently focusing their detection techniques in
low-mass WIMPs, which requires the use of light elements and low energy
threshold. In this context, we present the TREX-DM experiment, a low background
Micromegas-based TPC for low-mass WIMP detection. Its main goal is the
operation of an active detection mass 0.300 kg, with an energy threshold
below 0.4 keVee and fully built with previously selected radiopure materials.
This article describes the actual setup, the first results of the comissioning
in Ar+2\%iCH at 1.2 bar and the future updates for a possible
physics run at the Canfranc Underground Laboratory in 2016. A first background
model is also presented, based on Geant4 simulations and a muon/electron
discrimination method. In a conservative scenario, TREX-DM could be sensitive
to DAMA/LIBRA and other hints of positive WIMPs signals, with some space for
improvement with a neutron/electron discrimination method or the use of other
light gases.Comment: Proceedings of the 7th Symposium on Large TPCs for Low-Energy Rare
Event Detectio
Radiopurity of Micromegas readout planes
Micromesh Gas Amplification Structures (Micromegas) are being used in an
increasing number of Particle Physics applications since their conception
fourteen years ago. More recently, they are being used or considered as readout
of Time Projection Chambers (TPCs) in the field of Rare Event searches (dealing
with dark matter, axions or double beta decay). In these experiments, the
radiopurity of the detector components and surrounding materials is measured
and finely controlled in order to keep the experimental background as low as
possible. In the present paper, the first measurement of the radiopurity of
Micromegas planes obtained by high purity germanium spectrometry in the low
background facilities of the Canfranc Underground Laboratory (LSC) is
presented. The obtained results prove that Micromegas readouts of the microbulk
type are currently manufactured with radiopurity levels below 30 microBq/cm2
for Th and U chains and ~60 microBq/cm2 for 40K, already comparable to the
cleanest detector components of the most stringent low background experiments
at present. Taking into account that the studied readouts were manufactured
without any specific control of the radiopurity, it should be possible to
improve these levels after dedicated development.Comment: 15 pages, 2 figure
Lessons from the operation of the "Penning-Fluorescent" TPC and prospects
We have recently reported the development of a new type of high-pressure
Xenon time projection chamber operated with an ultra-low diffusion mixture and
that simultaneously displays Penning effect and fluorescence in the
near-visible region (300 nm). The concept, dubbed `Penning-Fluorescent' TPC,
allows the simultaneous reconstruction of primary charge and scintillation with
high topological and calorimetric fidelity
- …