Cellular and cytokine immunoregulation in patients with chronic obstructive pulmonary disease and bronchial asthma.

BACKGROUND: Different forms of chronic airway inflammation may involve diverse pathogenic elements. In general, deficient defence response is a feature of chronic obstructive pulmonary disease (COPD), whereas distorted immunoregulatory mechanisms lead to development of asthmatic symptoms. In addition to diverse effector mechanisms, the cellular and humoral elements participating in the development of immune response may appear to be different in COPD and bronchial asthma (BA) patients. AIMS: To evaluate the immunoregulatory properties of T cells and monocytes in cultures of peripheral blood mononuclear cells (PBMC) and to determine the chosen cytokine profiles in COPD and BA patients. METHODS: The microcultures of PBMC from COPD and BA patients were assessed for the T-cell response to mitogens, saturation of interleukin (IL)-2 receptors, T-cell suppressive activity and monokine influence on lymphocyte proliferation. Concomitantly, the cytokine (IL-1beta, interleukin-1 receptor antagonist, tumour necrosis factor-alpha, IL-4, IL-6, IL-8) concentrations were determined in the serum, the broncho-alveolar lavage fluid and in the culture supernatants. RESULTS: The T-lymphocyte reactions (response to phytohaemagglutinin, IL-2 receptor saturation, suppressive activity) were lower in BA patients than in COPD patients. Reversely, the immunogenic activity of monocytes (IL-1beta versus IL-1ra production) was higher in BA patients than in COPD patients. The highest values of cytokine concentrations were found in the culture supernatants. The concentrations of tumour necrosis factor-alpha, IL-4, IL-6 and IL-8 were significantly higher and the concentration of IL-1ra was lower in BA patients than in COPD patients. CONCLUSION: The assessments of cellular immunoregulatory properties and cytokine profiles in the cultures of blood mononuclear cells may prove helpful for diagnostic and therapeutic discrimination between BA and COPD patients

The Global Financial Crisis and its Impact on Emerging Market Economies in Europe and the CIS: Evidence from Mid-2010

Emerging market economies were major beneficiaries of the economic boom before 2007. More recently, they have become victims of the global financial crisis. Their future development depends, to a large extent, on global economic prospects. Today the global economy and the European economy are much more integrated and interdependent than they were ten or twenty years ago. Every country must recognize its limited economic sovereignty and must be prepared to deal with the consequences of global acroeconomic fluctuations. The statistical data for 2009 provides a mixed picture with respect to the impact of the crisis on various groups of countries and individual economies. On average, Central and Eastern Europe experienced a smaller output decline than the Euro area and the entire EU while the CIS, especially its European part, contracted more dramatically. However, there was a deep differentiation within each country group. Looking globally, richer countries, which are more open to trade and in which the banking sector plays a larger role and which rely more on external financing, suffered more than less sophisticated economies, which are less dependent on trade and credit (especially from external sources). With some exceptions, the previous good growth performance helped rather than handicapped countries in the CEE and CIS regions in the crisis year of 2009. The post-crisis recovery has been rather modest and incomplete. It remains vulnerable to new shocks (like the Greek Fiscal crisis), the danger of sovereign default and other uncertainties. Full post-crisis recovery and increasing potential growth will require far going economic and institutional reforms on both national, regional (e.g., EU) and global levels

Fiscal and Monetary Policy Determinants of the Eurozone Crisis and Its Resolution

Unlike the crisis years of 2007-2009 (when the insolvency of large banks was a major problem), the current round of the global financial crisis has fiscal origins. Almost all developed countries suffer from an excessive public debt burden that has been built up over the last two decades or more. The financial crisis caused a further deterioration of government accounts as a result of ill-tailored countercyclical fiscal response and, in some cases, a costly financial sector rescue. All excessively indebted countries must conduct fiscal adjustment, even if this involves economic and political costs in terms of lower output and higher unemployment. Central banks can reduce these costs through accommodative monetary policies but without compromising their anti-inflationary missions and institutional independence. The ECB is additionally constrained by its institutional status which is based on a delicate cross-country political consensus. Excessive ECB involvement in quasi-fiscal rescue operations can undermine this consensus and lead to a disintegration of the Eurozone. There are also strong arguments in favor of strengthening fiscal and banking integration within the EU, especially the fiscal discipline mechanism at national levels, and building the EU rescue capacity in respect to sovereigns and banks based on strong policy conditionality

Brane universes tested by supernovae

We discuss observational constrains coming from supernovae Ia \cite{Perlmutter99} imposed on the behaviour of the Randall-Sundrum models. In the case of dust matter on the brane, the difference between the best-fit general relativistic model with a $\Lambda$-term \cite{Perlmutter99} and the best-fit brane models becomes detectable for redshifts $z > 0.6$. It is interesting that brane models predict brighter galaxies for such redshifts which is in agreement with the measurement of the $z = 1.7$ supernova \cite{Riess01} and with the New Data from the High Z Supernovae Search Team \cite{schmit02}. We also demonstrate that the fit to supernovae data can also be obtained, if we admit the "super-negative" dark energy $p = - (4/3) \varrho$ on the brane, where the dark energy in a way mimics the influence of the cosmological constant. It also appears that the dark energy enlarges the age of the universe which is demanded in cosmology. Finally, we propose to check for dark radiation and brane tension by the application of the angular diameter of galaxies minimum value test.Comment: 4 pages, 5 figures, REVTEX4, amended versio

Macroeconomic and Fiscal Challenges Faced by the Southern and Eastern Mediterranean Region

The current fiscal imbalances and fragilities in the Southern and Eastern Mediterranean countries (SEMC) are the result of decades of instability, but have become more visible since 2008, when a combination of adverse economic and political shocks (the global and European financial crises, Arab Spring) hit the region. In an environment of slower growth and higher public expenditure pressures, fiscal deficits and public debts have increased rapidly. This has led to the deterioration of current accounts, a depletion of official reserves, the depreciation of some currencies and higher inflationary pressure. To avoid the danger of public debt and a balance-of-payment crisis, comprehensive economic reforms, including fiscal adjustment, are urgently needed. These reforms should involve eliminating energy and food subsidies and replacing them with targeted social assistance, reducing the oversized public administration and privatizing public sector enterprises, improving the business climate, increasing trade and investment openness, and sector diversification. The SEMC may also benefit from a peace dividend if the numerous internal and regional conflicts are resolved. However, the success of economic reforms will depend on the results of the political transition, i.e., the ability to build stable democratic regimes which can resist populist temptations and rally political support for more rational economic policies

The silicon Multiplicity Detector for the NA50 experiment

Abstract The operation and performance of the silicon strip Multiplicity Detector in the heavy-ion experiment NA50 at CERN are presented together with a selection of physics results. The main features of the detector are high speed (50 MHz sampling frequency), high granularity (more than 13,000 strips), and good radiation resistance. The detector provided a measurement of event centrality in Pb–Pb collisions, as well as target identification and the measurement of charged particle pseudorapidity distributions as a function of centrality

The silicon multiplicity detector for the NA50 experiment at CERN

The design, operation and performance of the silicon strip Multiplicity Detector for the heavy-ion experiment NA50 at CERN are presented. The main features of the detector are high speed (50 MHz sampling frequency), high granularity (more than 13,000 strips), and good radiation resistance. The detector provided a measurement ofevent centrality in Pb–Pb collisions, as well as target identification and the measurement ofcharged particle pseudorapidity distributions as a function of centrality. r 2002 Elsevier Science B.V. All rights reserved. PACS: 29.4

Analysis of radiation effects on silicon strip detectors in the NA50 experiment

Abstract During the operation of the Multiplicity Detector in the NA50 experiment the single sided AC-coupled p-on-n silicon strip detectors were exposed to charged particle fluences resulting in an equivalent 1 MeV neutron fluence up to 10 14 eq. n/cm 2 and a total ionising dose up to 20 Mrad, with a very non-uniform radiation spatial distribution. In this paper detailed analysis of radiation effects observed on the detectors during the 1996 lead ion run as well as results of measurements performed after the run are presented

Design and operation of a fast high-granularity silicon detector system in a high-radiation environment

Abstract We have designed, realized and operated a fast silicon detector system (50 MHz sampling frequency) to measure the angular distribution and the multiplicity of charged secondaries produced in high-energy Pb–Pb interactions, within the NA50 experiment. We present here the detector design, discuss some of the problems faced during the commissioning and report on the first results on the operation of the full system. In particular, the questions related to the operation of an integrated high-speed binary readout in a high-radiation environment (1014 particles/cm2 and about 10 Mrads) and to the radiation effects on the system during the run will be addressed