Influenza vaccination for immunocompromised patients: summary of a systematic review and meta-analysis

Vaccination of immunocompromised patients is recommended in many national guidelines to protect against severe or complicated influenza infection. However, due to uncertainties over the evidence base, implementation is frequently patchy and dependent on individual clinical discretion. We conducted a systematic review and meta‐analysis to assess the evidence for influenza vaccination in this patient group. Healthcare databases and grey literature were searched and screened for eligibility. Data extraction and assessments of risk of bias were undertaken in duplicate, and results were synthesised narratively and using meta‐analysis where possible. Our data show that whilst the serological response following vaccination of immunocompromised patients is less vigorous than in healthy controls, clinical protection is still meaningful, with only mild variation in adverse events between aetiological groups. Although we encountered significant clinical and statistical heterogeneity in many of our meta‐analyses, we advocate that immunocompromised patients should be targeted for influenza vaccination

Influenza vaccination for immunocompromised patients: systematic review and meta-analysis from a public health policy perspective.

Immunocompromised patients are vulnerable to severe or complicated influenza infection. Vaccination is widely recommended for this group. This systematic review and meta-analysis assesses influenza vaccination for immunocompromised patients in terms of preventing influenza-like illness and laboratory confirmed influenza, serological response and adverse events

Virtual Prototypes and Product Models in Mechanical Engineering

This paper gives an overview of some of the modelling and virtual prototyping techniques used in product realization, with emphasis on the mechanical engineering eld. It is pointed out that virtual prototypes, in the commonly accepted sense of computer models permitting realistic graphical simulation, represent only one class amongst the many types of computer models used in design and planning for manufacture. Each such model is usually created for some comparatively narrow purpose, and one of the major problems faced by developers of integrated computer-aided product realization systems concerns the transmutation of one type of model into another. A related problem is that of interpretation by any model of information generated by interrogations of another model. These diculties are compounded by the increasing presence in such models of semantic information concerning dierent aspects of the intended functionality or manufacturing requirements of the modelled artefact. Keywords M..