Micro Chemical Analysis Systems. Introduction, Fabrication Technologies, Instrumentation And Applications [microssistemas De Análises Químicas. Introdução, Tecnologias De Fabricação, Instrumentação E Aplicações]

The amazing world of micro total analysis systems has provided a true revolution in analytical chemistry in recent years. The application of the microfluidic devices for chemical and biochemical processing has attracted considerable interest due to its advantages such as reduced sample and reagent consumption, processing time, energy, waste, cost, and portability. The aim of the present report is to disseminate the state of the art related to the miniaturization science in Analytical Chemistry. Historical progress, microfabrication technologies, required instrumentation and applications of the ?TAS are presented in the current article, with special attention to the Brazilian contributions.30819862000van den Berg, A., Lammerink, T.S.J., (1998) Top. Curr. Chem, 194, p. 21Reyes, D.R., Iossifidis, D., Auroux, P.A., Manz, A., (2002) Anal. Chem, 74, p. 2623Auroux, P.A., Iossifidis, D., Reyes, D.R., Manz, A., (2002) Anal.Chem, 74, p. 2637Vilkner, T., Janasek, D., Manz, A., (2004) Anal. Chem, 76, p. 3373Dittrich, P.S., Tachikawa, K., Manz, A., (2006) Anal. Chem, 78, p. 3887Madou, M.J., (2002) Fundamentals of Microfabrication, , 2nd ed, CRC Press: New YorkEhrfeld, W., (2003) Electrochim. Acta, 20, p. 2857Wooley, A.T., Lao, K., Glazer, A.N., Mathies, R.A., (1998) Anal. Chem, 70, p. 684Terry, S.C., Jerman, J.H., Angell, J.B., (1979) IEEE Trans. Electron Devices, ED-26, p. 1880Manz, A., Miyahara, Y., Miura, J., Watanabe, Y., Miyagi, H., Sato, K., (1990) Sens. Actuators, B, 1, p. 249Manz, A., Graber, N., Widmer, H.M., (1990) Sens. Actuators, B, 1, p. 244(1999) Lab-on-a-chip: The Revolution in portable instrumentation, , http://www.frost.com/prod/servlet/frost-home.pag, 3 rd ed, &, New York, p17Gulliksen, A., Solli, L., Karlsen, F., Rogne, H., Hovig, E., Nordstrom, T., Sirevág, R., (2003) Anal. Chem, 76, p. 9Chen, Y., Pépin, A., (2002) Electrophoresis, 22, p. 187Meyerhofer, D., (1978) J. Appl. Phys, 49, p. 3993Ericson, C., Holm, J., Ericson, T., Hjertén, S., (2000) Anal. Chem, 72, p. 81Lagally, E.T., Simpson, P.C., Mathies, R.A., (2000) Sens. Actuators, B, 63, p. 138Xiong, L., Regnier, F.E., (2001) J. Chromatrogr., A, 924, p. 165Jacobson, S.C., Hergenröder, R., Koutny, L.B., Warmack, R.J., Ramsey, J.M., (1994) Anal. Chem, 66, p. 1107He, B., Tait, N., Regnier, F., (1998) Anal. Chem, 70, p. 3790Coltro, W. K. T.Piccin, E.Fracassi da Silva, J. A.do Lago, C. L.Carrilho, E.Lab Chip 2007, 7, 931Fintschenko, Y., van den Berg, A., (1998) J. Chromatogr., A, 819, p. 3Schultz, G.A., Corso, T.N., Prosser, S.J., Zhang, S., (2000) Anal. Chem, 72, p. 4058Lao, A.I.K., Lee, T.M.H., Sing, I.-M., Ip, N.Y., (2000) Sens. Actuators, A, 84, p. 11Harrison, D.J., Manz, A., Fan, Z., Ludi, H., Widmer, H.M., (1992) Anal. Chem, 64, p. 1926Wang, H.Y., Foote, R.S., Jacobson, S.C., Schneibel, J.H., Ramsey, J.M., (1997) Sens. Actuators, B, 45, p. 199Mcdonald, J.C., Whitesides, G.M., (2002) Acc. Chem. Res, 35, p. 491Becker, H., Gartner, C., (2000) Electrophoresis, 21, p. 12Becker, H., Locascio, L.E., (2002) Talanta, 56, p. 223Quist, A.P., Pavlovic, E., Oscarsson, S., (2005) Anal. Bioanal. Chem, 381, p. 591Martynova, L., Locascio, L.E., Gaitan, M., Kramer, G.W., Christensen, R.G., MacCrehan, W.A., (1997) Anal. Chem, 69, p. 4783McCormick, R.M., Nelson, R.J., Alonso-Amigo, M.G., Benvegnu, D.J., Hooper, H.H., (1997) Anal. Chem, 69, p. 2626Xu, J., Locascio, L., Gaitan, M., Lee, S.C., (2000) Anal. Chem, 72, p. 1930Duffy, D.C., Mcdonald, J.C., Schueller, O.J.A., Whitesides, G.M., (1998) Anal. Chem, 70, p. 4974Yi, L., Xiaodong, W., Chong, L., Zhifeng, L., Denan, C., Dehui, Y., (2005) Microsyst. Technol, 11, p. 1272Xia, Y., Whitesides, G.M., (1998) Annu. Rev. Mater. Sci, 28, p. 153Whitesides, G.M., Ostuni, E., Takayama, S., Jiang, X., Ingber, D.E., (2001) Annu. Rev. Biomed. Eng, 3, p. 335Mcdonald, J.C., Duffy, D.C., Anderson, J.R., Chiu, D.T., Wu, H., Schueller, O.J.A., Whitesides, G.M., (2000) Electrophoresis, 21, p. 27Whitesides, G.M., Sia, S.K., (2003) Electrophoresis, 24, p. 3563Piccin, E., Coltro, W.K.T., Fracassi da Silva, J.A., Mazo, L.H., Claro-Neto, S., Carrilho, E., (2007) J. Chromatogr., A, , doi:10.1016/j. chroma.2007.09.081Chen, G., Bao, H.M., Li, J.H., Chen, D., (2006) Microchim. Acta, 153, p. 151Velten, T., Ruf, H.H., Barrow, D., Aspragathos, N., Lazarou, P., Jung, E., Malek, C.K., Kruckow, J., (2005) IEEE Trans. Adv. Packag, 28, p. 533Roberts, M.A., Rossier, J.S., Bercier, P., Girault, H., (1997) Anal. Chem, 69, p. 2035Tan, A.M., Rodgers, K., Murrihy, J.P., O'Mathuna, C., Glennon, J.D., (2001) Lab Chip, 1, p. 7do Lago C. L.da Silva, H. D. T.Neves, C. A.Fracassi da Silva, J. A.Anal. Chem. 2003, 75, 3853Coltro, W. K. T.Fracassi da Silva, J. A.da Silva, H. D. T.Richter, E. M.Furlan, R.Angnes, L.do Lago C. L.Mazo, L. H.Carrilho, E.Electrophoresis 2004, 25, 3832He, F.Y., Liu, A.L., Yuan, J.H., Coltro, W.K.T., Carrilho, E., Xia, X.H., (2005) Anal. Bioanal. Chem, 382, p. 192Liu, A.L., He, F.Y., Hu, Y.L., Xia, X.H., (2006) Talanta, 68, p. 1303Coltro, W.K.T., Fracassi da Silva, J.A., Carrilho, E., Electrophoresis, , submetidoLiu, A.L., He, F.Y., Wang, K., Zhou, T., Lu, Y., Xia, X.H., (2005) Lab Chip, 5, p. 974Daniel, D., Gutz, I.G.R., (2003) Electrochem. Commun, 5, p. 782Richter, E. M.Fracassi da Silva, J. A.Gutz, I. G. R.do Lago, C. L.Angnes, L.Electrophoresis 2004, 25, 2965Daniel, D., Gutz, I.G.R., (2005) Talanta, 68, p. 429Bao, N., Zhang, Q., Xu, J.J., Chen, H.Y., (2005) J. Chromatogr., A, 1089, p. 270do Lago, C. L.de Jesus, D. P.da Silva, H. T. D.Neves, C. A.Fracassi da Silva, J. A.Electrophoresis 2004, 25, 3825de Jesus, D.P., Blanes, L., do Lago, C.L., (2006) Electrophoresis, 27, p. 4935Li, M.W., Huynh, B.H., Hulvey, M.K., Lunte, S.M., Martin, R.S., (2006) Anal. Chem, 78, p. 1042Karling, J.M., Monahan, J., Marchiarullo, D.J., Ferrance, J.P., Landers, J.P., (2005) Anal. Chem, 77, p. 3637Hisamoto, H., Horiuchi, T., Uchiyama, K., Tokeshi, M., Hibara, A., Kitamori, T., (2001) Anal. Chem, 73, p. 5551Laser, D.J., Santiago, J.G., (2004) J. Micromech. Microeng, 14, pp. R35Andersson, H., van der Wijngaart, W., Nilsson, P., Enoksson, P., Stemme, G., (2001) Sensors Actuators, B, 72, p. 259Unger, M.A., Chou, H.-P., Thorsen, T., Scherer, A., Quake, S.R., (2000) Science, 288, p. 7Figeys, D., Pinto, D., (2000) Anal. Chem, 72, pp. 330ACulbertson, C.T., Ramsey, R.S., Ramsey, J.M., (2000) Anal. Chem, 72, p. 2285McKnight, T.E., Culbertson, C.T., Jacobson, S.C., Ramsey, J.M., (2001) Anal. Chem, 73, p. 4045Morf, W.E., Guenat, O.T., de Rooij, N.F., (2001) Sensors Actuators, B, 72, p. 266Ni, J., Zhong, C.-J., Coldiron, S.J., Porter, M.D., (2001) Anal. Chem, 73, p. 103Tas, N.R., Berenschot, J.W., Lammerink, T.S.J., Elwenspoek, M., van den Berg, A., (2002) Anal. Chem, 74, p. 2224Yin, Z., Prosperetti, A., (2005) J. Micromech. Microeng, 15, p. 643Chen, G., Wang, J., (2004) Analyst, 129, p. 507Fang, Q., (2004) Anal. Bioanal. Chem, 378, p. 49Backofen, U., Matysik, F.-M., Lunte, C.E., (2002) Anal. Chem, 74, p. 4054Solignac, D., Gijs, M.A.M., (2003) Anal. Chem, 75, p. 1652Martin, R.S., Gawron, A.J., Lunte, S.M., Henry, C.S., (2000) Anal. Chem, 72, p. 3196Alarie, J.P., Jacobson, J.C., Ramsey, J.M., (2001) Electrophoresis, 22, p. 312Jacobson, S.C., Ramsey, J.M., (1995) Electrophoresis, 16, p. 481Jacobson, S.C., Ermakov, S.V., Ramsey, J.M., (1999) Anal. Chem, 71, p. 3273http://www.emcohighvoltage.com, acessada em Abril 2006http://www.matsusada.com, acessada em Abril 2006Garcia, C.D., Liu, Y., Anderson, P., Henry, C.S., (2003) Lab Chip, 3, p. 324Mogensen, K.B., Klank, H., Kutter, J.P., (2004) Electrophoresis, 25, p. 3498Viskari, P.J., Landers, J.P., (2006) Electrophoresis, 27, p. 1797Pumera, M., Merkoc, A., Alegret, S., (2006) Trends Anal. Chem, 25, p. 219Wang, J., (2005) Electroanalysis, 17, p. 1133http://www.chem.agilent.com/Scripts/PDS.ASP?lPage=51, acessada em Setembro 2006Lacher, N.A., Garrison, K.E., Martin, R.S., Lunte, S.M., (2001) Electrophoresis, 22, p. 2526Vandaveer, W.R., Pasas-Farmer, S.A., Fischer, D.J., Frankenfeld, C.N., Lunte, S.M., (2004) Electrophoresis, 25, p. 3528Brito-Neto, J.G.A., Fracassi da Silva, J.A., Blanes, L., Lago, C.L., (2005) Electroanalysis, 17, p. 1198Brito-Neto, J.G.A., Fracassi da Silva, J.A., Blanes, L., Lago, C.L., (2005) Electroanalysis, 17, p. 1207http://www.chem.agilent.com/Scripts/PDS.ASP?lpage=38308, acessada em Setembro 2006van Bentum, P.J.M., Janssen, J.W.G., Kentgens, A.P.M., (2004) Analyst, 129, p. 793Bilitewski, U., Genrich, M., Kadow, S., Mersal, G., (2003) Anal. Bioanal. Chem, 377, p. 556Effenhauser, C.S., Paulus, A., Manz, A., Widmer, H.M., (1994) Anal. Chem, 66, p. 2949Liu, S., Guttman, A., (2004) Trends Anal. Chem, 23, p. 422Khandurina, J., Guttman, A., (2002) J. Chromatogr., A, 943, p. 159Sun, Y., Kwok, Y.C., (2006) Anal. Chim. Acta, 556, p. 80Anderson, H., van den Berg, A., (2003) Sens. Actuators, B, 92, p. 315Wilding, P., Kricka, L.J., Cheng, J., Hvichia, G., Shoffner, M.A., Fortina, P., (1998) Anal. Biochem, 257, p. 95Carlson, R., Gabel, C., Chan, S., Austin, R., (1997) Phys. Rev. Lett, 79, p. 2149Huang, Y., Yang, J.M., Hopkins, P.J., Kassegne, S., Tirado, M., Forster, A.H., Reese, H., (2003) Biomed. Microdev, 5, p. 217Cui, L., Zhang, T., Morgan, H., (2002) J. Micromech. Microeng, 12, p. 7Schilling, E., Kamholz, A., Yager, P., (2002) Anal. Chem, 74, p. 798Irimia, D., Tompkins, R.G., Toner, M., (2004) Anal. Chem, 76, p. 6137Carlo, D.D., Zanetti, C.I., Zhang, Y., Hung, P., Lee, L.P., (2005) Lab Chip, 5, p. 171Taylor, M., Belgrader, P., Furman, B., Pourahmadi, F., Kovacs, G., Northrup, A., (2001) Anal. Chem, 73, p. 492Lu, H., Schimidt, E.L., Jensen, K.F., (2005) Lab. Chip, 5, p. 23Fox, M.B., Esveld, D.C., Valero, A., Luttge, R., Mastwijk, H.C., Bartels, P.V., van den Berg, A., Boom, R.M., (2006) Anal. Bioanal. Chem, 385, p. 474Verpoorte, E., (2003) Lab Chip, 3, pp. 60NChung, Y.C., Jan, M.S., Lin, Y.C., Lin, Y.H., Cheng, W.C., Fan, C.Y., (2004) Lab Chip, 4, p. 141Roper, M.G., Easley, C.J., Landers, J.P., (2005) Anal. Chem, 77, p. 3887Legendre, L.A., Bienvenue, J.M., Roper, M.G., Ferrance, J.P., Landers, J.M., (2006) Anal. Chem, 78, p. 1444Hashimoto, M., Chen, P.C., Mitchell, M.W., Nikitopoulos, D.E., Soper, S.A., Murphy, M.C., (2004) Lab Chip, 4, p. 638Emrich, C.H., Tian, H., Medintz, I.L., Mathies, R.A., (2002) Anal. Chem, 74, p. 5076Ferrance, J.P., Wu, Q., Giordano, B., Hernandez, C., Kwok, Y., Snowb, K., Thibodeau, S., Landers, J.P., (2003) Anal. Chim. Acta, 500, p. 223Soper, S.A., Ford, A.M., Xu, Y.C., Qi, S.Z., McWhorter, S., Lassiter, S., Patterson, D., Bruch, R.C., (1999) J. Chromatogr., A, 853, p. 107Liu, R.H., Yang, J.N., Lenigk, T., Bonanno, J., Grodzinski, P., (2004) Anal. Chem, 76, p. 1824Sung, W.C., Makamba, H., Chen, S., (2005) Electrophoresis, 26, p. 1783Rocklin, R.D., Ramsey, R.S., Ramsey, J.M., (2000) Anal. Chem, 72, p. 5244Ramsey, J.D., Jacobson, S.C., Culbertson, C.T., Ramsey, J.M., (2003) Anal. Chem, 75, p. 3758Shadpour, H., Soper, S.A., (2006) Anal. Chem, 78, p. 3519Herr, A.E., Molho, J.I., Drouvalakis, K.A., Mikkelsen, J.C., Utz, P.J., Santiago, J.G., Kenny, T.W., (2003) Anal. Chem, 75, p. 1180Griebel, A., Rund, S., Schemed, F., Doerner, W., Konrad, R., Hardt, S., (2004) Lab Chip, 4, p. 18Liu, Y., Garcia, C.D., Henry, C.S., (2003) Analyst, 128, p. 1002Wang, J., (2002) Electrophoresis, 23, p. 713Hadd, A.G., Raymond, D.E., Halliwell, J.W., Jacobson, S.C., Ramsey, J.M., (1997) Anal. Chem, 69, p. 3407Hadd, A.G., Jacobson, S.C., Ramsey, J.M., (1999) Anal.Chem, 71, p. 5206Wang, J., Ibáñes, A., Chatrathi, M.P., (2003) J. Am. Chem. Soc, 125, p. 8444Gawron, A.J., Martin, S., Lunte, S.M., (2001) Eur. J. Pharm. Sci, 14, p. 1Willauer, H.D., Collins, G.E., (2003) Electrophoresis, 24, p. 2193Dolnik, V., Liu, S., (1994) J. Sep. Sci, 2005, p. 28Osbourn, D.M., Lunte, C.E., (2003) Anal. Chem, 75, p. 2710Baldwin, R.P., Roussel, T.J., Crain, M.M., Bathlagunda, A., Jackson, D.J., Gullapalli, J., Conklin, J.A., Keynton, R.S., (2002) Anal. Chem, 74, p. 3690Muck, A., Wang, J., Jacobs, M., Chen, G., Chatrathi, M.P., Jurka, V., Výborný, Z., Schoning, M.J., (2004) Anal. Chem, 76, p. 2290Johirul, M., Shiddiky, A., Kim, R.E., Shim, Y.B., (2005) Electrophoresis, 26, p. 3043Munro, N.J., Huang, Z., Finegold, D.N., Landers, J.P., (2000) Anal. Chem, 72, p. 2765Throckmorton, D.J., Shepodd, T.J., Singh, A.K., (2002) Anal. Chem, 74, p. 784Wang, J., Chen, G., Pumera, M., (2003) Electroanalysis, 15, p. 862García, C.D., Henry, C.S., (2003) Anal. Chem, 75, p. 4778Abad-Villar, E.M., Kubán, P., Hauser, P.C., (2005) Electrophoresis, 26, p. 3609Suzuki, S., Honda, S., (2003) Electrophoresis, 24, p. 3577García, C.D., Henry, C., (2004) Anal. Chim. Acta, 508, p. 1Schwarz, M.A., Galliker, B., Fluri, K., Kappes, T., Hauser, P.C., (2001) Analyst, 126, p. 147Wang, J., Chen, G., Wang, M., Chatrathi, M.P., (2004) Analyst, 129, p. 512Wang, J., Chen, G., Chatrathi, M.P., (2004) Electroanalysis, 16, p. 1603Dang, F., Kakehi, K., Nakajima, K., Shinohara, Y., Ishikawa, M., Kaji, N., Tokeshi, M., Baba, Y., (2006) J. Chromatogr., A, 1109, p. 138Zamfir, A.D., Bindila, L., Lion, N., Allen, M., Girault, H.H., Peter-Katalinic, J., (2005) Electrophoresis, 26, p. 3650Honda, S., Suzuki, S., Taga, A., (2003) J. Pharm. Biomed. Anal, 30, p. 1689Belder, D., Ludwig, M., (2003) Electrophoresis, 24, p. 2422Schwarz, M.A., Hauser, P.C., (2003) Anal. Chem, 75, p. 4691Hutt, L.D., Glavin, D.P., Bada, J.L., Mathies, R.A., (1999) Anal. Chem, 71, p. 4000Rodríguez, I., Jin, L.J., Li, S.F.Y., (2000) Electrophoresis, 21, p. 211Piehl, N., Ludwig, M., Belder, D., (2004) Electrophoresis, 25, p. 3848Gao, Y., Shen, Z., Wang, H., Dai, Z., Lin, B., (2005) Electrophoresis, 26, p. 477