48 research outputs found
Sorologia rápida para hansenÃase (teste ML Flow) em pacientes dimorfos classificados como paucibacilares pelo número de lesões cutâneas: uma ferramenta útil
Prevention of repeated episodes of type 2 reaction of leprosy with the use of thalidomide 100 mg/day
Efeitos adversos da poliquimioterapia em pacientes com hansenÃase: um levantamento de cinco anos em um Centro de Saúde da Universidade Federal de Uberlândia
Granulomatous Reactivation during the Course of a Leprosy Infection: Reaction or Relapse
Leprosy is a serious infectious disease whose treatment still poses some challenges. Patients are usually treated with a combination of antimicrobial drugs called multidrug therapy. Although this treatment is effective against Mycobacterium leprae, the bacillus that causes leprosy, patients may develop severe inflammatory reactions during treatment. These reactions may be either attributed to an improvement in the immunological reactivity of the patient along with the treatment, or to relapse of the disease due to the proliferation of remaining bacilli. In certain patients these two conditions may be difficult to differentiate. The present study addresses the histopathology picture of and the M. leprae bacilli in sequential biopsies taken from lesions of patients who presented such reactions aiming to improve the differentiation of the two conditions. This is important because these reactions are one of the major causes of the disabilities of the patients with leprosy, and should be treated early and appropriately. Our results show that the histopathology picture alone is not sufficient, and that bacilli's counting is necessary