Rhabdomyolysis due to the additive effect of statin therapy and hypothyroidism: a case report

We describe a patient with previously undiagnosed hypothyroidism who developed rhabdomyolysis while taking a statin. He had no other precipitating factors. The statin was stopped, intravenous fluids were started immediately and L-thyroxin was given after confirming the diagnosis of hypothyroidism. His symptoms improved over a few days. Because rhabdomyolysis is a rare but potentially life threatening disorder when complicated by acute tubular necrosis and renal failure, physicians must pay special attention when starting statins in patients with hyperlipidemia

FARKLI TUTKALLARIN KAYIN ve SARIÇAM AĞAÇLARINDAKİ YAPIŞMA DİRENÇLERİNİN BELİRLENMESİ

Bu çalışmada, poliüretan esaslı Pu-Mon ve Pu-Ma, polivinilasetat esaslı PVAc-MA22, PVAc-MA35 ve PVAc-MA50 ile yapıştırılmış Doğu kayını (Fagus orientalis L.) ve sarıçam (Pinus Sylvestris L.) odunlarının yapışma direnci, TS EN 205 esaslarına göre belirlenmiştir. Deney sonuçlarına göre, en yüksek yapışma direnci Pu-Ma (16.01 N/mm2) ve PVAc-MA35 (15.12 N/mm2) ile yapıştırılmış kayın numunelerinde, en düşük yapışma direnci ise Pu-Mon (7.98 N/mm2) ve PVAc-MA35 (7.67 N/mm2) ile yapıştırılmış sarıçam numunelerinde tespit edilmiştir. 

Rhabdomyolysis due to the additive effect of statin therapy and hypothyroidism: a case report

Abstract We describe a patient with previously undiagnosed hypothyroidism who developed rhabdomyolysis while taking a statin. He had no other precipitating factors. The statin was stopped, intravenous fluids were started immediately and L-thyroxin was given after confirming the diagnosis of hypothyroidism. His symptoms improved over a few days. Because rhabdomyolysis is a rare but potentially life threatening disorder when complicated by acute tubular necrosis and renal failure, physicians must pay special attention when starting statins in patients with hyperlipidemia.</p

CFD modeling of carbon combustion and electrode radiation in an electric arc furnace

This paper, concentrates on a three-dimensional (3D) computational fluid-dynamics (CFD) model for coal combustion and electrode radiation inside an electric-arc furnace (EAF). Simulation of the melting process includes combustion reactions of coal particles and radiation from electrodes. Particle surface and gas phase reactions were used to predict injected coal particle combustion. The predicted temperature distributions are realistic because of the inclusion of combustion reactions and radiation models together. The CFD model provided detail information for the coal particles combustion and radiation interactions phoneme inside the electric-arc furnace. The cooling process of the EAF walls were considered in the CFD model hence heat losses from the walls have been found higher than the earlier studies. Results showed that CFD simulation can efficiently be used to develop and investigate EAF in design phase. (C) 2015 Elsevier Ltd. All rights reserved

CFD modeling of carbon combustion and electrode radiation in an electric arc furnace

This paper, concentrates on a three-dimensional (3D) computational fluid-dynamics (CFD) model for coal combustion and electrode radiation inside an electric-arc furnace (EAF). Simulation of the melting process includes combustion reactions of coal particles and radiation from electrodes. Particle surface and gas phase reactions were used to predict injected coal particle combustion. The predicted temperature distributions are realistic because of the inclusion of combustion reactions and radiation models together. The CFD model provided detail information for the coal particles combustion and radiation interactions phoneme inside the electric-arc furnace. The cooling process of the EAF walls were considered in the CFD model hence heat losses from the walls have been found higher than the earlier studies. Results showed that CFD simulation can efficiently be used to develop and investigate EAF in design phase. (C) 2015 Elsevier Ltd. All rights reserved

Purification and selected biochemical properties of peroxidase from cress (Lepidium sativum sub sp. sativum)

Cress (Lepidium sativum) is an annual herb from Brassicaceae family, and in some regions. It is known as peppergrass, garden cress, garden peppercress, pepperwort, or poor man’s pepper. Cress is an important medicinal plant in some countries including Turkey. This plant has major scientific and therapeutic significance. Peroxidase (POD, E.C.1.11.1.7) is an oxidoreductase enzyme produced by a number of organisms. In this study, POD enzyme was purified from cress by ammonium sulphate precipitation, gel filtration, and CM-Sephadex ion-exchange chromatographies. Km and Vmax values were calculated from the Lineweaver-Burk graph for H2O2 and guaiacol substrates and the substrate specificity of POD was investigated. The results showed that substrate specificity of H2O2 is better than substrate specificity of guaiacol for this enzyme. The inhibition effects of three cations (Al3+, Cu2+, and Cr3+) and one organic compound of cetyl trimethylammonium bromide were performed and their inhibition types were determined. Finally, optimum pH, optimum temperature, optimum ionic strength, and stable pH were determined

Ortalama trombosit hacmi ve otonomik sinir sistemi fonksiyonları arasındaki ilişki: Artmış ortalama trombosit hacmi sempatetik aktivite artışını yansıtır

Amaç: Artmış ortalama trombosit hacmi (OTH) trombosit aktivasyonundaki artışı yansıtır ve bağımsız bir koroner risk faktörü olarak kabul edilir. Adrenerjik sistemin trombosit aktivasyonu ve trombosit oluşumunda etkileri vardır. Bu çalışmada, akut miyokard enfarktüslü (ME) hastalarda otonomik sinir sistemi aktivasyonunun OTH üzerine etkileri araştırılmıştır. Yöntem ve Gereç: Akut ön duvar enfarktüslü 47 hasta koroner arterleri normal olan 32 hasta ile karşılaştırılmıştır. Tüm hastalara 24 saatlik holter monitörizasyonu ile kalp hız değişikliği analizi yapılmış ve OTH ölçümü için kan örnekleri alınmıştır. Bulgular: Akut ME’lü hastalarda ortalama kalp hızı (KH), Düşük frekans (LF), LF/Yüksek frekans (HF) oranı, OTH kontrol grubundan daha yüksek, Tüm NN aralıklarının standart sapması (SDNN), takip eden farkların kare kökü (RMSSD), bir sonrakinden 50 ms’den fazla farklılık gösteren NN aralıklarının tüm NN aralıklarına oranı (PNN50), HF ve trombosit sayısı daha düşük bulunmuştur. Her iki grupta gündüz LF, LF/HF, ve OTH değerleri geceki değerlerden daha yüksek bulunmuş ancak akut ME’lü hastalarda bu farkın çok daha anlamlı olduğu görülmüştür. Korelasyon analizinde OTH ile ventrikül skoru, sol ön inen arterdeki darlık derecesi, ortalama KH, LF, LF/HF arasında pozitif bir ilişki; SDNN, HF ve trombosit sayısı arasında negatif bir ilişki olduğunu göstermiştir. Multivaryant analiz OTH’nin ventrikül skoru ve LF/HF oranından etkilendiğini göstermiştir. Sonuç: ME’lü hastalarda OTH anlamlı olarak yüksektir. Her iki çalışma grubunda da gündüz ve gece OTH değerlerinde önemli değişim görülmekte ve bu değişim otonomik sinir sistemindeki değişimden kaynaklanmaktadır. Miyokard enfarktüslü hastalarda artmış OTH’nin prognostik değerinin bu hastalardaki artmış sempatetik aktivite ve azalmış kalp hızı değişikliği ile yakın ilişkili olduğu düşünülebilir.Aim: Increased mean platelet volume (MPV) may reflect increased platelet activation and accepted as an independent coronary risk factor. Adrenergic system has effects on platelet activation and thrombocytopoiesis. In this study, we assessed the effects of autonomic nervous system activity on MPV in patients with acute myocardial infarction (MI). Materials and Methods: Forty-seven patients with acute anterior MI were compared with 32 patients having normal coronary arteries. All patients underwent heart rate variability analysis by 24-h holter monitoring and blood samples were taken for MPV measurements during day and night times during holter monitoring. Results: Mean heart rate (HR), Low frequency (LF), LF/High frequency (HF) ratio, MPV were higher, standard deviation of all NN intervals (SDNN), root mean square of successive differences (RMSSD), the number of NN intervals that differed by more than 50 ms from adjacent interval divided by the total number of all NN intervals (PNN50), HF and platelet counts were lower in the patients with anterior MI compared to the control group. Day time LF, LF/HF, and MPV were significantly higher and HF were significantly lower compared to those measured during night time in both groups. Pearson's correlation analysis showed that MPV was positively correlated with ventricle score, degree of left anterior descending artery stenosis, mean HR, LF, LF/HF, and negatively correlated with SDNN, HF, and platelet count. Multivariate analysis revealed that MPV was affected by ventricle score and LF/HF ratio. Conclusions: MPV is significantly higher in the patients with MI and MPV in both groups shows great diurnal and nocturnal variation that is attributed to the alterations in the autonomic nervous system. We suggest that prognostic role of increased MPV in patients with MI are closely associated with increased sympathetic activity and decreased heart rate variability in these patients

Homosistein ve akut miyokard infarktüsü sonrası erken dönemde koroner kollateral gelişimi

Amaç: Homosisteinin endotelyal hücre proliferasyonunu inhibe ettiği bilinmektedir. Koroner kollateral dolaşımın gelişimini etkileyen faktörler iyi bilinmemektedir. Bu çalışmada plazma homosistein düzeylerinin akut miyokard infarktüsü sonrası anjiyografik olarak saptanabilen kollaterallerin gelişimi üzerine tekisi araştırılmıştır. Yöntem ve Gereç: Çalışmaya akut ST yükselmeli miyokard infarktüsü geçiren 60 hasta alınmıştır. Tüm hastalara hastaneye yatırıldıktan sonraki 1-4. günler arasında koroner anjiyografi yapılmıştır (ortalama 2,3 ± 1,2 gün). Kollateral damar gelişimi rentrop sınıflamasına göre derecelendirilmiş, 0 ve 1 kötü kollateral gelişimi, 2 ve 3 ise iyi kollateral gelişimi olarak gruplandırılmıştır. Bulgular: 35 hastada (% 58,3) kötü kollateral gelişimi saptanmıştır. Geri kalan 25 hastada ise (% 41,7) kollateral gelişimin iyi olduğu görülmüştür. Ortalama plasma homosistein konsantrasyonu kötü ve iyi kollateral grublarında sırasıyla 18,2 ± 8,6 ?mol/l ve 12,7 ± 2,4 ?mol/l bulunmuştur (P = 0,008). Rentrop sınıfı ile homosistein düzeyi arasında anlamlı negatif korelasyon olduğu görülmüştür (r = –0,391, P = 0,002). Yaş, cinsiyet, hipertansiyon, diyabet varlığı, sigara alışkanlığı, plazma lipid parametreleri ve homosistein konsantrasyonlarının kollateral gelişimi üzerine etkisine bakıldığında, kollateral gelişini etkileyen tek bağımsız değişkenin homosistein olduğu görülmüştür (OR: 0,71; % 95 güven aralığı 0,57-0,89, P = 0,003). Sonuç: Bu çalışma ile plazma homosistein konsantrasyonları ile akut miyokard infarktüsü sonrası erken dönemdeki kollateral gelişimi arasındaki negatif ilişkinin varlığı ilk kez gösterilmiştir.Aim: Homocysteine is known to inhibit endothelial cell proliferation, which is a key event in angiogenesis. Factors responsible for the presence or absence of coronary collateral circulation are poorly understood. Therefore, in this study we investigated the effect of plasma homocysteine level on the early formation of angiographically visible collaterals after acute myocardial infarction. Materials and Methods: The study included 60 patients that had ST-segment elevation myocardial infarction (STEMI). All the patients underwent coronary angiography 1-4 days after admission (mean: 2.3 ± 1.2 days). Patients were graded according to Rentrop classification. Patients with grade 0 or 1 collateral vessels were classified as poor collaterals; patients with grade 2 or 3 collateral vessels were classified as good collaterals. Results: In all, 35 (58.3%) patients had poor collateral vessel filling and the remaining 25 (41.7%) patients had good collateral filling. Plasma homocysteine concentration in patients with poor and good collateral formation was 18.2 ± 8.6 µmol/l and 12.7 ± 2.4 µmol/l, respectively (P = 0.008). There was a negative linear correlation between Rentrop subclasses and plasma homocysteine concentration (r = –0.391, P = 0.002). We assessed the effect of demographic variables, such as age, gender, hypertension, diabetes mellitus, smoking, lipid parameters, and plasma homocysteine concentration, on the development of collaterals. The only independent variable that affected the development of collaterals was homocysteine level (OR: 0.71; 95% CI = 0.57-0.89, P = 0.003). Conclusions: This study demonstrates for the first time that there is an inverse relationship between the early development of collateral circulation after acute myocardial infarction and plasma homocysteine concentration

2D Materials (WS₂, MoS₂, MoSe₂) Enhanced Polyacrylamide Gels for Multifunctional Applications

Multifunctional polymer composite gels have attracted attention because of their high thermal stability, conductivity, mechanical properties, and fast optical response. To enable the simultaneous incorporation of all these different functions into composite gels, the best doping material alternatives are two-dimensional (2D) materials, especially transition metal dichalcogenides (TMD), which have been used in so many applications recently, such as energy storage units, opto-electronic devices and catalysis. They have the capacity to regulate optical, electronic and mechanical properties of basic molecular hydrogels when incorporated into them. In this study, 2D materials (WS2, MoS2 and MoSe2)-doped polyacrylamide (PAAm) gels were prepared via the free radical crosslinking copolymerization technique at room temperature. The gelation process and amount of the gels were investigated depending on the optical properties and band gap energies. Band gap energies of composite gels containing different amounts of TMD were calculated and found to be in the range of 2.48–2.84 eV, which is the characteristic band gap energy range of promising semiconductors. Our results revealed that the microgel growth mechanism and gel point of PAAm composite incorporated with 2D materials can be significantly tailored by the amount of 2D materials. Furthermore, tunable band gap energies of these composite gels are crucial for many applications such as biosensors, cartilage repair, drug delivery, tissue regeneration, wound dressing. Therefore, our study will contribute to the understanding of the correlation between the optical and electronic properties of such composite gels and will help to increase the usage areas so as to obtain multifunctional composite gels