5,291 research outputs found
Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited
The cellular and molecular mechanisms of tumor angiogenesis and its prospects for anti-angiogenic cancer therapy are major issues in almost all current concepts of both cancer biology and targeted cancer therapy. Currently, (1) sprouting angiogenesis, (2) vascular co-option, (3) vascular intussusception, (4) vasculogenic mimicry, (5) bone marrow-derived vasculogenesis, (6) cancer stem-like cell-derived vasculogenesis and (7) myeloid cell-driven angiogenesis are all considered to contribute to tumor angiogenesis. Many of these processes have been described in developmental angiogenesis; however, the relative contribution and relevance of these in human brain cancer remain unclear. Preclinical tumor models support a role for sprouting angiogenesis, vascular co-option and myeloid cell-derived angiogenesis in glioma vascularization, whereas a role for the other four mechanisms remains controversial and rather enigmatic. The anti-angiogenesis drug Avastin (Bevacizumab), which targets VEGF, has become one of the most popular cancer drugs in the world. Anti-angiogenic therapy may lead to vascular normalization and as such facilitate conventional cytotoxic chemotherapy. However, preclinical and clinical studies suggest that anti-VEGF therapy using bevacizumab may also lead to a pro-migratory phenotype in therapy resistant glioblastomas and thus actively promote tumor invasion and recurrent tumor growth. This review focusses on (1) mechanisms of tumor angiogenesis in human malignant glioma that are of particular relevance for targeted therapy and (2) controversial issues in tumor angiogenesis such as cancer stem-like cell-derived vasculogenesis and bone-marrow-derived vasculogenesis
The End of the Lines for OX 169: No Binary Broad-Line Region
We show that unusual Balmer emission line profiles of the quasar OX 169,
frequently described as either self-absorbed or double peaked, are actually
neither. The effect is an illusion resulting from two coincidences. First, the
forbidden lines are quite strong and broad. Consequently, the [N II]6583 line
and the associated narrow-line component of H-alpha present the appearance of
twin H-alpha peaks. Second, the redshift of 0.2110 brings H-beta into
coincidence with Na I D at zero redshift, and ISM absorption in Na I D divides
the H-beta emission line. In spectra obtained over the past decade, we see no
substantial change in the character of the line profiles, and no indication of
intrinsic double-peaked structure. The H-gamma, Mg II, and Ly-alpha emission
lines are single peaked, and all of the emission-line redshifts are consistent
once they are correctly attributed to their permitted and forbidden-line
identifications. A systematic shift of up to 700 km/s between broad and narrow
lines is seen, but such differences are common, and could be due to
gravitational and transverse redshift in a low-inclination disk. Stockton &
Farnham (1991) had called attention to an apparent tidal tail in the host
galaxy of OX 169, and speculated that a recent merger had supplied the nucleus
with a coalescing pair of black holes which was now revealing its existence in
the form of two physically distinct broad-line regions. Although there is no
longer any evidence for two broad emission-line regions in OX 169, binary black
holes should form frequently in galaxy mergers, and it is still worthwhile to
monitor the radial velocities of emission lines which could supply evidence of
their existence in certain objects.Comment: 19 pages, 5 figures, accepted for publication in Ap.
X-ray enabled MOCASSIN: a 3D code for photoionized media
We present a new version of the fully 3D photoionization and dust radiative
transfer code, MOCASSIN, that uses a Monte Carlo approach for the transfer of
radiation. The X-ray enabled MOCASSIN allows a fully geometry independent
description of low-density gaseous environments strongly photoionized by a
radiation field extending from radio to gamma rays. The code has been
thoroughly benchmarked against other established codes routinely used in the
literature, using simple plane parallel models designed to test performance
under standard conditions. We show the results of our benchmarking exercise and
discuss applicability and limitations of the new code, which should be of
guidance for future astrophysical studies with MOCASSIN.Comment: Accepted for publication in ApJS 9 pages, 5 figure
Radar Detection of High Concentrations of Ice Particles - Methodology and Preliminary Flight Test Results
High Ice Water Content (HIWC) has been identified as a primary causal factor in numerous engine events over the past two decades. Previous attempts to develop a remote detection process utilizing modern commercial radars have failed to produce reliable results. This paper discusses the reasons for previous failures and describes a new technique that has shown very encouraging accuracy and range performance without the need for any hardware modifications to industrys current radar designs. The performance of this new process was evaluated during the joint NASA/FAA HIWC RADAR II Flight Campaign in August of 2018. Results from that evaluation are discussed, along with the potential for commercial application, and development of minimum operational performance standards for a future commercial radar product
Acute Effects of Delta-9-Tetrahydrocannabinol on Performance Monitoring in Healthy Volunteers
Rationale: The error-related negativity (ERN) is a negative event-related potential that occurs immediately after an erroneous response and is thought to reflect human performance monitoring. Delta-9-Tetrahydrocannabinol (THC) administration in healthy volunteers has been linked to impaired performance monitoring in behavioral studies, but to date no studies have examined the effects of cannabinoids on the ERN. Methods: EEG data from 10 healthy volunteers was recorded during execution of a speeded choice-reaction-time task (Flankers task) after administration of THC or placebo vapor in a double-blind randomized crossover design. Results: The findings of this study show that the ERN was significantly reduced after administration of THC. The behavioral outcomes on the Flankers task showed no indications of drug-induced impairments. Discussion: The diminished ERN reflects impairments in the process of performance monitoring. The task design was not optimized to find behavioral effects. The study shows that cannabinoids impair performance monitoring
Emission-Line Properties of z > 4 Quasars
We present results of a program of high signal-to-noise spectroscopy for 44
QSOs at redshifts > 4 using the MMT and Keck observatories. The quasar spectra
cover 1100 -- 1700 A in the rest frame for sources spanning a luminosity range
of approximately 2 orders of magnitude. Comparisons between these data and
spectra of lower redshift quasars reveal a high degree of similarity, although
differences are present in the profiles and the strengths of some emission
features. An examination of the luminosity dependence of the emission lines
reveals evidence for a weak or absent Baldwin effect among z > 4 QSOs. We
compare measurements for objects in our sample with results from other high
redshift surveys characterized by different selection techniques. Distributions
of equivalent widths for these different ensembles are consistent with a common
parent population, suggesting that our sample is not strongly biased, or in any
case, subject to selection effects that are not significantly different from
other surveys, including the Sloan Digital Sky Survey. Based on this
comparison, we tentatively conclude that the trends identified here are
representative of high z QSOs. In particular, the data bolster indications of
supersolar metallicities in these luminous, high-z sources, which support
scenarios that assume substantial star formation at epochs preceding or
concurrent with the QSO phenomena.Comment: 26 pages (incl. 9 figures), AASTeX v5.0, to appear in The
Astrophysical Journa
Phase Control of Nonadiabaticity-induced Quantum Chaos in An Optical Lattice
The qualitative nature (i.e. integrable vs. chaotic) of the translational
dynamics of a three-level atom in an optical lattice is shown to be
controllable by varying the relative laser phase of two standing wave lasers.
Control is explained in terms of the nonadiabatic transition between optical
potentials and the corresponding regular to chaotic transition in mixed
classical-quantum dynamics. The results are of interest to both areas of
coherent control and quantum chaos.Comment: 3 figures, 4 pages, to appear in Physical Review Letter
Aperiodic Ising Quantum Chains
Some years ago, Luck proposed a relevance criterion for the effect of
aperiodic disorder on the critical behaviour of ferromagnetic Ising systems. In
this article, we show how Luck's criterion can be derived within an exact
renormalisation scheme for Ising quantum chains with coupling constants
modulated according to substitution rules. Luck's conjectures for this case are
confirmed and refined. Among other outcomes, we give an exact formula for the
correlation length critical exponent for arbitrary two-letter substitution
sequences with marginal fluctuations of the coupling constants.Comment: 27 pages, LaTeX, 1 Postscript figure included, using epsf.sty and
amssymb.sty (one error corrected, some minor changes
- …