Neural Mechanisms for Information Compression by Multiple Alignment, Unification and Search

This article describes how an abstract framework for perception and cognition may be realised in terms of neural mechanisms and neural processing. This framework — called information compression by multiple alignment, unification and search (ICMAUS) — has been developed in previous research as a generalized model of any system for processing information, either natural or artificial. It has a range of applications including the analysis and production of natural language, unsupervised inductive learning, recognition of objects and patterns, probabilistic reasoning, and others. The proposals in this article may be seen as an extension and development of Hebb’s (1949) concept of a ‘cell assembly’. The article describes how the concept of ‘pattern’ in the ICMAUS framework may be mapped onto a version of the cell assembly concept and the way in which neural mechanisms may achieve the effect of ‘multiple alignment’ in the ICMAUS framework. By contrast with the Hebbian concept of a cell assembly, it is proposed here that any one neuron can belong in one assembly and only one assembly. A key feature of present proposals, which is not part of the Hebbian concept, is that any cell assembly may contain ‘references’ or ‘codes’ that serve to identify one or more other cell assemblies. This mechanism allows information to be stored in a compressed form, it provides a robust mechanism by which assemblies may be connected to form hierarchies and other kinds of structure, it means that assemblies can express abstract concepts, and it provides solutions to some of the other problems associated with cell assemblies. Drawing on insights derived from the ICMAUS framework, the article also describes how learning may be achieved with neural mechanisms. This concept of learning is significantly different from the Hebbian concept and appears to provide a better account of what we know about human learning

How do faculty and staff perceive the effectiveness of student support systems that promote the retention of First-Generation College Students?

Research showed faculty-student interactions impact student engagement and was a primary factor to student retention (Kuh & Hu, 2001; Means & Pyne, 2017; Swecker et al., 2013; Tinto, 1987). The literature revealed while retention may be an issue for many institutions, there is a greater need to address retention specifically related to first-generation college students (FGCS). Students often seek advice from faculty and staff when faced with questions about their academic progress. Faculty and staff voices need to be collected regarding their perceptions of the effectiveness of the support systems used within an institution that promote retention for FGCS. This dissertation research study aimed to explore faculty and staff perceptions of the factors that influence retention with a qualitative-dominant explanatory sequential mixed-methods research design. In the first phase, twenty-three (n = 23) faculty and staff at a two-year community college in southeastern Minnesota participated in an online questionnaire. Key findings from Phase One included faculty and staff perceived Academic Integration, Academic Conscientiousness, Support Service Satisfaction, and Financial Strain as having a significant impact on retention of FGCS and they perceive themselves as slightly prepared to advise FGCS on topics related to Financial Strain. In the second phase, eight (n = 8) faculty and staff from the same institution participated in an interview. Key findings from Phase Two included 50% of faculty and staff commented that the institution’s support systems for FGCS were effective; of those, 66.6% of staff commented these support systems were effective whereas 40% of faculty perceived the supports as effective. This research study added to the body of literature regarding research that focused on faculty and staff perceptions regarding FGCS retention, the use of the mixed-methods approach to explore retention, and the exploration of FGCS retention at a two-year institution

Introduction.: Narrating Reality in Comics

Introduction to the Special Issue by the Guest Editor

Einleitung.: Wirklichkeit erzählen im Comic

Einleitung der Gastherausgeber/in des Themenheft

Meperidine Suppresses the Excitability of Spinal Dorsal Horn Neurons

Background: In addition to local anesthetics, meperidine has been successfully used for local anesthesia. When applied intrathecally, the dorsal horn neurons of the superficial laminae are exposed to high concentrations of meperidine. These cells represent an important point for the transmission of pain information. This study investigated the blocking effects of meperidine on different ionic currents of spinal dorsal horn neurons and, in particular, its impact on the generation of action potentials. Methods: Using a combination of the patch clamp technique and the entire soma isolation method, the action of meperidine on voltage-gated Na ؉ and K ؉ currents in spinal dorsal hor

Foot Bone in Vivo: Its Center of Mass and Centroid of Shape

This paper studies foot bone geometrical shape and its mass distribution and establishes an assessment method of bone strength. Using spiral CT scanning, with an accuracy of sub-millimeter, we analyze the data of 384 pieces of foot bones in vivo and investigate the relationship between the bone's external shape and internal structure. This analysis is explored on the bases of the bone's center of mass and its centroid of shape. We observe the phenomenon of superposition of center of mass and centroid of shape fairly precisely, indicating a possible appearance of biomechanical organism. We investigate two aspects of the geometrical shape, (i) distance between compact bone's centroid of shape and that of the bone and (ii) the mean radius of the same density bone issue relative to the bone's centroid of shape. These quantities are used to interpret the influence of different physical exercises imposed on bone strength, thereby contributing to an alternate assessment technique to bone strength.Comment: 9 pages, 4 figure

Alvimopan for the Management of Postoperative Ileus After Bowel Resection: Characterization of Clinical Benefit by Pooled Responder Analysis

BACKGROUND: A pooled post hoc responder analysis was performed to assess the clinical benefit of alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist, for the management of postoperative ileus after bowel resection. METHODS: Adult patients who underwent laparotomy for bowel resection scheduled for opioid-based intravenous patient-controlled analgesia received oral alvimopan or placebo preoperatively and twice daily postoperatively until hospital discharge or for 7 postoperative days. The proportion of responders and numbers needed to treat (NNT) were examined on postoperative days (POD) 3-8 for GI-2 recovery (first bowel movement, toleration of solid food) and hospital discharge order (DCO) written. RESULTS: Alvimopan significantly increased the proportion of patients with GI-2 recovery and DCO written by each POD (P \u3c 0.001 for all). More patients who received alvimopan achieved GI-2 recovery on or before POD 5 (alvimopan, 80%; placebo, 66%) and DCO written before POD 7 (alvimopan, 87%; placebo, 72%), with corresponding NNTs equal to 7. CONCLUSIONS: On each POD analyzed, alvimopan significantly increased the proportion of patients who achieved GI-2 recovery and DCO written versus placebo and was associated with relatively low NNTs. The results of these analyses provide additional characterization and support for the overall clinical benefit of alvimopan in patients undergoing bowel resection

Screen for Genetic Modifiers of stbm Reveals that Photoreceptor Fate and Rotation Can Be Genetically Uncoupled in the Drosophila Eye

BACKGROUND: Polarity of the Drosophila compound eye arises primarily as a consequence of two events that are tightly linked in time and space: fate specification of two photoreceptor cells, R3 and R4, and the subsequent directional movement of the unit eyes of the compound eye, or ommatidia. While it is thought that these fates dictate the direction of ommatidial rotation, the phenotype of mutants in the genes that set up this polarity led to the hypothesis that these two events could be uncoupled. METHODOLOGY/PRINCIPAL FINDINGS: To definitively demonstrate these events are genetically separable, we conducted a dominant modifier screen to determine if genes, when misexpressed, could selectively enhance subclasses of mutant ommatidia in which the direction of rotation does not follow the R3/R4 cell fates, yet not affect the number of ommatidia in which rotation follows the R3/R4 cell fates. We identified a subset of P element lines that exhibit this selective enhancement. We also identified lines that behave in the opposite manner: They enhance the number of ommatidia that rotate in the right direction, but do not alter the number of ommatidia that rotate incorrectly with respect to the R3/R4 fates. CONCLUSIONS/SIGNIFICANCE: These results indicate that fate and direction of rotation can be genetically separated, and that there are genes that act between R3/R4 fate specification and direction of ommatidial rotation. These data affirm what has been a long-standing assumption about the genetic control of ommatidial polarity

HAGE (DDX43) is a biomarker for poor prognosis and a predictor of chemotherapy response in breast cancer

Background: HAGE protein is a known immunogenic cancer-specific antigen. Methods: The biological, prognostic and predictive values of HAGE expression was studied using immunohistochemistry in three cohorts of patients with BC (n=2147): early primary (EP-BC; n=1676); primary oestrogen receptor-negative (PER-BC; n=275) treated with adjuvant anthracycline-combination therapies (Adjuvant-ACT); and primary locally advanced disease (PLA-BC) who received neo-adjuvant anthracycline-combination therapies (Neo-adjuvant-ACT; n=196). The relationship between HAGE expression and the tumour-infiltrating lymphocytes (TILs) in matched prechemotherapy and postchemotherapy samples were investigated. Results: Eight percent of patients with EP-BC exhibited high HAGE expression (HAGEþ) and was associated with aggressive clinico-pathological features (Ps<0.01). Furthermore, HAGEþexpression was associated with poor prognosis in both univariate and multivariate analysis (Ps<0.001). Patients with HAGE+ did not benefit from hormonal therapy in high-risk ER-positive disease. HAGE+ and TILs were found to be independent predictors for pathological complete response to neoadjuvant-ACT; P<0.001. A statistically significant loss of HAGE expression following neoadjuvant-ACT was found (P=0.000001), and progression-free survival was worse in those patients who had HAGE+ residual disease (P=0.0003). Conclusions: This is the first report to show HAGE to be a potential prognostic marker and a predictor of response to ACT in patients with BC