43 research outputs found
A Functional Variant in MicroRNA-146a Promoter Modulates Its Expression and Confers Disease Risk for Systemic Lupus Erythematosus
- Author
- A Mencia
- A Rahman
- AM Delgado-Vega
- B Xu
- Betty P. Tsao
- C Xiao
- D Baltimore
- DL Flesher
- Dong-Qing Ye
- DP Bartel
- DP D'Cruz
- EC Baechler
- Edward K. Wakeland
- EF Remmers
- G Curtale
- G Hom
- GM Han
- HF Lodish
- Huijuan Cui
- JB Harley
- JC Barrett
- JW Han
- K Jazdzewski
- KD Taganov
- KK Wu
- L Bennett
- L Ronnblom
- L Ronnblom
- MK Crow
- MK Crow
- Nan Shen
- Nattiya Hirankarn
- Niek de Vries
- OJ Rullo
- Paul Peter Tak
- R Duan
- RR Graham
- RR Graham
- RR Graham
- S Purcell
- S Sigurdsson
- SN Kariuki
- SV Kozyrev
- T Xu
- V Gateva
- V Pascual
- W Yang
- Wanling Yang
- X Luo
- Xiaobing Luo
- Xiaoxia Qian
- Y Tang
- Yan Zhang
- Yu Lung Lau
- Yuanjia Tang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a strong genetic predisposition, characterized by an upregulated type I interferon pathway. MicroRNAs are important regulators of immune homeostasis, and aberrant microRNA expression has been demonstrated in patients with autoimmune diseases. We recently identified miR-146a as a negative regulator of the interferon pathway and linked the abnormal activation of this pathway to the underexpression of miR-146a in SLE patients. To explore why the expression of miR-146a is reduced in SLE patients, we conducted short parallel sequencing of potentially regulatory regions of miR-146a and identified a novel genetic variant (rs57095329) in the promoter region exhibiting evidence for association with SLE that was replicated independently in 7,182 Asians (Pmeta = 2.74×10−8, odds ratio = 1.29 [1.18–1.40]). The risk-associated G allele was linked to reduced expression of miR-146a in the peripheral blood leukocytes of the controls. Combined functional assays showed that the risk-associated G allele reduced the protein-binding affinity and activity of the promoter compared with those of the promoter containing the protective A allele. Transcription factor Ets-1, encoded by the lupus-susceptibility gene ETS1, identified in recent genome-wide association studies, binds near this variant. The manipulation of Ets-1 levels strongly affected miR-146a promoter activity in vitro; and the knockdown of Ets-1, mimicking its reduced expression in SLE, directly impaired the induction of miR-146a. We also observed additive effects of the risk alleles of miR-146a and ETS1. Our data identified and confirmed an association between a functional promoter variant of miR-146a and SLE. This risk allele had decreased binding to transcription factor Ets-1, contributing to reduced levels of miR-146a in SLE patients
Unauthorized Horizontal Spread in the Laboratory Environment: The Tactics of Lula, a Temperate Lambdoid Bacteriophage of Escherichia coli
- Author
- A Kuzminov
- A Kuzminov
- A Matsushiro
- AA Vostrov
- Andrei Kuzminov
- B Thoms
- BJ Bachmann
- BJ Barnhart
- C Mundy
- CD Jepson
- DP Kozyrev
- EC Friedberg
- EcoliWiki
- EL Bolt
- EL Ellis
- Ella Rotman
- FX Abad
- G Bogosian
- G Edlin
- H Takebe
- HS James
- JJ Dermody
- JR Songer
- KC Katz
- KE Jones
- L Amado
- LM Van Valen
- LN Csonka
- Luciana Amado
- M Radman
- Martin G. Marinus
- MH Adams
- ML Campbell-Renton
- MT Kenny
- N De Lappe
- P Howard-Flanders
- P Howard-Flanders
- P Hughes
- RE Anderson
- RG Lloyd
- RH Haynes
- RW Hendrix
- S Aizawa
- S Rottem
- T Segawa
- T Trouwborst
- T Trouwborst
- T Trouwborst
- TN Mandal
- Trouwborst
- VN Rybchin
- WJ Burman
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
We investigated the characteristics of a lambdoid prophage, nicknamed Lula, contaminating E. coli strains from several sources, that allowed it to spread horizontally in the laboratory environment. We found that new Lula infections are inconspicuous; at the same time, Lula lysogens carry unusually high titers of the phage in their cultures, making them extremely infectious. In addition, Lula prophage interferes with P1 phage development and induces its own lytic development in response to P1 infection, turning P1 transduction into an efficient vehicle of Lula spread. Thus, using Lula prophage as a model, we reveal the following principles of survival and reproduction in the laboratory environment: 1) stealth (via laboratory material commensality), 2) stability (via resistance to specific protocols), 3) infectivity (via covert yet aggressive productivity and laboratory protocol hitchhiking). Lula, which turned out to be identical to bacteriophage phi80, also provides an insight into a surprising persistence of T1-like contamination in BAC libraries
Search for Higgs Boson Pair Production in the Four b Quark Final State in Proton-Proton Collisions at root s=13 TeV
- Author
- Aarrestad T
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WW
- Abdullin S
- Abercrombie D
- Abreu A
- Acharya H
- Acosta D
- Adam W
- Adamidis K
- Adams E
- Adams M
- Adams T
- Addesa F
- Adloff C
- Adzic P
- Adán DP
- Afanasiev S
- Agapitos A
- Agarwal G
- Aggleton R
- Agram J
- Aguilar-Benitez M
- Ahmad A
- Ahmad M
- Ahmad WH
- Ahmed A
- Ahuja S
- Aime` C
- Akchurin N
- Akgun B
- Akpinar A
- Albergo S
- Albert A
- Albrecht S
- Albrow M
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Almond J
- Alonso AG
- Alpana K
- Alvarez JR
- Alverson G
- Alves G
- Aly R
- Alyari M
- Amapane N
- Amaral SSD
- Amarilo KM
- Ambrozas M
- Amendola C
- Amin N
- Amram O
- Amsler C
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- Anagnostou G
- Anampa KH
- Andrea J
- Andreassi G
- Andreev V
- Andreev Y
- Andrejkovic J
- Andrews M
- Androsov K
- Angioni GP
- Anguiano J
- Antchev G
- Antequera JB
- Anthony D
- Antunovic Z
- Anuar AB
- Apollinari G
- Apparu D
- Appelt E
- Apresyan A
- Apyan A
- Araujo M
- Arcaro D
- Arcidiacono R
- Arenton M
- Argiro S
- Arneodo M
- Aruta C
- Asavapibhop B
- Asawatangtrakuldee C
- Asenov P
- Asghar M
- Asilar E
- Askew A
- Asmuss P
- Atakisi I
- Attikis A
- Auffray E
- Aushev T
- Auzinger G
- Avati V
- Avery P
- Avila C
- Awais A
- Awan M
- Ayala E
- Ayala G
- Azarkin M
- Azhgirey I
- Aziz T
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- Azzurri P
- Baarmand M
- Babaev A
- Bacchetta N
- Bachiller I
- Bachtis M
- Backhaus M
- Baden A
- Baechler J
- Bagliesi G
- Bahinipati S
- Baillon P
- Bainbridge R
- Bakas G
- Bakhshiansohi H
- Bakshi A
- Ban Y
- Band R
- Bandyopadhyay H
- Banerjee S
- Banos LE
- Bansal S
- Barbagli G
- Barberis E
- Bargassa P
- Baringer P
- Barnes V
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- Barrera CB
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- Yalvac M
- Yan F
- Yan X
- Yang S
- Yang U
- Yang Y
- Yao Y
- Yarar H
- Yates B
- Yazgan E
- Ye Z
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- Yi K
- Yigitbasi E
- Yohay R
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- Yuldashev B
- Yumiceva F
- Yusli M
- Yzquierdo AP
- Zabi A
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- Zahid S
- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
- Zarucki M
- Zecchinelli A
- Zeinali M
- Zeuner W
- Zghiche A
- Zhang F
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- Zhang Y
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- Zhizhin I
- Zhokin A
- Zhu D
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- Ziemons T
- Zoi I
- Zolkapli Z
- Zorbakir I
- Zorbilmez C
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- Zou R
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Álvarez CR
- Özçelik Ö
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Search for invisible decays of the Higgs boson produced via vector boson fusion in proton-proton collisions at root s=13 TeV
- Author
- Aarrestad T
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim A
- Abdullin S
- Abercrombie D
- Abreu A
- Acharya H
- Acosta D
- Acosta HE
- Adam W
- Adamidis K
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- Adzic P
- Adán DP
- Afanasiev S
- Agapitos A
- Agarwal G
- Aggleton R
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- Aguilar-Benitez M
- Ahmad A
- Ahmad M
- Ahmad WH
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- Aimè C
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- Akgun B
- Akpinar A
- Albergo S
- Albert A
- Albrecht S
- Albrow M
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
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- Alonso AG
- Alpana A
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- Alverson G
- Alves BFS
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- Alyari M
- Amapane N
- Amaral SSD
- Amarilo KM
- Ambrozas M
- Amendola C
- Amin N
- Amram O
- Amsler C
- An S
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- Anagnostou G
- Anampa KH
- Andrea J
- Andreassi G
- Andreev V
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- Arcaro D
- Arcidiacono R
- Arenton M
- Argiro S
- Arneodo M
- Aruta C
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- Asawatangtrakuldee C
- Asenov P
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- Attikis A
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- Auzinger G
- Avati V
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- Lee K
- Lee R
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- Lee Y
- Leggat D
- Legger F
- Lehti S
- Leiton AS
- Lelas D
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- Lethuillier M
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- Liu M
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- Lizzo M
- Lo K
- Lobanov A
- Loeliger A
- Lohmann W
- Lokhtin I
- Lomidze I
- Long K
- Long O
- Longo E
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- Lotfy A
- Lotti M
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- Madigan G
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- Marzocchi B
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- Massironi A
- Mastrapasqua V
- Mastrolorenzo L
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- Matveev V
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- Mazumdar K
- Mcalister I
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- Norjoharuddeen NB
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- Tomalin I
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- Von Cube R
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- Wissing C
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- Wyslouch B
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- Xiang Y
- Xiao J
- Xiao M
- Xiao R
- Xie S
- Xie W
- Yagil A
- Yalvac M
- Yan F
- Yan X
- Yang H
- Yang S
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- Yao Y
- Yarar H
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- Yi K
- Yigitbasi E
- Yohay R
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- Yoo J
- Yoon I
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- Yu D
- Yu G
- Yu I
- Yu Pr
- Yu S
- Yuan L
- Yuan S
- Yuldashev B
- Yumiceva F
- Yzquierdo AP
- Zabi A
- Zacharopoulou A
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
- Zarucki M
- Zecchinelli A
- Zeinali M
- Zeuner W
- Zghiche A
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang W
- Zhang Y
- Zhang Z
- Zhao J
- Zhizhin I
- Zhokin A
- Zhu R
- Ziemons T
- Zipper N
- Zoi I
- Zolkapli Z
- Zorbakir I
- Zorbilmez C
- Zotto P
- Zotz A
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- Zou R
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Álvarez CR
- Özçelik Ö
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Alternative splicing: the pledge, the turn, and the prestige
- Author
- A Aartsma-Rus
- A Berger
- A DeMicco
- A Goren
- A Haraga
- A Ivanov
- A Kalsotra
- A Krämer
- A Malamitsi-Puchner
- A Mankodi
- A Pawellek
- A Peri
- A Sureau
- A Sveen
- A Zaghlool
- A. C. Leote
- AA Melton
- AD Norris
- AG Matera
- AGL Douglas
- AJ Linares
- AJ Ward
- AJ Westermann
- AJ Westermann
- AL Shaffer
- AM Muise
- AN Brooks
- AN Kuhn
- AR Grosso
- AR Grosso
- AR Krainer
- AR Krainer
- AV Chee
- B Chabot
- B Hu
- B Ng
- B Raj
- B Raj
- B Raj
- B Ruskin
- B Ruskin
- B Treutlein
- BD Berkovits
- BJ Albert
- BJ Blencowe
- BJG Baaten
- BK Dredge
- C Francavilla
- C Gao
- C Ghigna
- C Holland
- C Karakaya
- C Kress
- C Liu
- C Vernet
- C Wei
- C Zhu
- CA Opitz
- CA Turner Jr
- CH George
- CJ David
- CJ David
- CK Vuong
- CM Koh
- CR Rothrock
- CV Clower
- D Ahmadi Rastegar
- D Dominguez
- D Hanahan
- D Kumar
- D Lipscombe
- D Memon
- D Sakamuro
- DD Licatalosi
- DD Licatalosi
- DG Nowak
- DJ Elliott
- DO Bates
- DP Hughes
- DW Seol
- DW Walke
- E Brody
- E Lara-Pezzi
- E Lara-Pezzi
- E Sebestyén
- E Sebestyén
- EJ Love
- EL Heinzen
- ES Goers
- ET Wang
- ET Wang
- EY Osman
- F Melchers
- F Wang
- FALM Eskens
- G Lamson
- G Lev-Maor
- G Magistrelli
- G McClorey
- G Pintucci
- G Yeo
- H Bierne
- H Cheng
- H Domdey
- H Dvinge
- H Dvinge
- H Gallinaro
- H Jung
- H Maatz
- H Wang
- H Yong
- H-Y Wang
- HC DeGrendele
- HE Bryant
- HR Hernandez-Lopez
- I Evsyukova
- I Meininger
- IS Trowbridge
- J Bao
- J Bauman
- J Cheng
- J Derbinski
- J Giudice
- J Giudice
- J Guo
- J Häsler
- J Merkin
- J Okuda
- J Rogers
- J Solana
- J Ule
- J Ule
- J Wang
- J Woolard
- J Xu
- J Yang
- J-A Lee
- J-H Kim
- JA Calarco
- JC Leggere
- JC Shultz
- JD Topp
- JE Lee
- JG Conboy
- JK Nussbacher
- JM Izquierdo
- JM Izquierdo
- JM Simon
- JP Venables
- JP Venables
- JR Tollervey
- JW Harbour
- JY Ip
- KK Kim
- KS Sciabica
- KW Lynch
- L Cartegni
- L Chen
- L Conti De
- L Du
- L Klein
- L Saucedo
- L Sedlackova
- L Traunmüller
- L. M. Gallego-Paez
- LB Motta-Mena
- LH Boise
- LS Young
- LT Chow
- LT Gehman
- M Ajiro
- M Danan-Gotthold
- M Danan-Gotthold
- M Fardilha
- M Gigli
- M Hafner
- M Irimia
- M Ladomery
- M Llorian
- M Martin
- M McFarlane
- M Merkenschlager
- M Minnich
- M Pistoni
- M Polymenidou
- M Preussner
- M Ryan
- M Salton
- M Sammeth
- M Ver Heyen
- M Yano
- M Zahid
- M. Ascensão-Ferreira
- M. C. Bordone
- MA Garcia-Blanco
- MA Havens
- MA Havens
- MA Jensen
- MB Coelho
- MB Warf
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- MF Krummel
- MG Rosenfeld
- MG Rosenfeld
- MJ Benson
- MJ Mallory
- MJ Moore
- MK Oaks
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- MM Scotti
- MP Paronetto
- MP Paronetto
- MR Cookson
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- MS Anderson
- N Charlet-B
- N Droin
- N Hamada
- N Iwamori
- N Keppetipola
- N Martínez-Montiel
- N-T Chiou
- N. L. Barbosa-Morais
- N. Saraiva-Agostinho
- NA Olshavsky
- NL Barbosa-Morais
- NM Martinez
- NN Singh
- NS Foulkes
- O Anczuków
- O Anczuków
- O Kelemen
- O Muhlemann
- O Rossbach
- P Early
- P Early
- P Tucker
- PA Merwe van der
- PC Beverley
- PC Beverley
- PD Stenson
- PL Boutz
- PW Gunning
- Q Li
- R Aprianto
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- R Ashwal-Fluss
- R Benabdillah
- R Jia
- R Karni
- R Klinck
- R Lambrot
- R Reed
- R Schmid
- R Spellman
- R Sperling
- RA Padgett
- RF Luco
- RM Sandri-Goldin
- RP House
- RS Savkur
- RW Ching
- S Alsafadi
- S Berto
- S Bonomi
- S Carpenter
- S Fletcher
- S Gueroussov
- S Leu
- S Oberdoerffer
- S Oltean
- S Ramalingam
- S Rosenberger
- S Shen
- S Zheng
- SD Wagner
- SE Butcher
- SF Nagueh
- SM Berget
- SM Dehm
- SM Rueter
- SM Weyn-Vanhentenryck
- SP Wongpalee
- SV Graham
- SV Kozyrev
- T Fukuhara
- T Hermann
- T Iijima
- T Iijima
- T Nojima
- T Stiewe
- TH Ho
- TM Miller
- TR Webb
- TY-T Hsu
- U Rosani
- V Cognata La
- V Gonçalves
- V Runfola
- VR Moulton
- W Gilbert
- W Guo
- W Liu
- W Xia
- W Zhong
- WR Jeck
- X-D Fu
- Y Barash
- Y Kanemori
- Y Kanemori
- Y Ohshima
- Y Onouchi
- Y Wang
- Y Xue
- Y Zhang
- Y-H Goo
- Y-S Lin
- YS Tsai
- Z Xu
- ZM Zheng
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The IL-2/CD25 Pathway Determines Susceptibility to T1D in Humans and NOD Mice
- Author
- A Kukreja
- A Liston
- A Toda
- A Vella
- A Zhernakova
- AA Caudy
- AB Begovich
- AE Herman
- AL Bayer
- AL Putnam
- AM Pollard
- AV Villarino
- B Sadlack
- B Salomon
- BF Treiger
- BH Nelson
- BJ Barratt
- C Baecher-Allan
- C Baecher-Allan
- C Teuscher
- Calliope A. Dendrou
- CE Lowe
- CL Bennett
- CL Jiang
- CS Henney
- D Girard
- D Smyth
- DA Hafler
- DA Heel van
- DA Shackelford
- DC Parker
- DG Norman
- DJ Stauber
- DM Eicher
- DM Eicher
- DM Willerford
- DP Gong
- DT Leung
- E Gambineri
- E Jaeckel
- EA Green
- EJ Gordon
- EM Kniep
- EM Shevach
- EV O’Loughlin
- F Cozzolino
- F Granucci
- F Granucci
- F Pericle
- FD Shi
- FO Martinez
- G Roncador
- GCL Johnson
- H Dooms
- H Kobayashi
- H Schorle
- H Ueda
- HP Kim
- HQ Qu
- I Espinoza-Delgado
- J Lang
- J Waithman
- J Yamanouchi
- JA Encinas
- JA Todd
- JD Fontenot
- JD Fontenot
- JL Davies
- JL Matsuda
- JM Chapman
- JM Ellery
- JR Ortaldo
- JW Mier
- JX Lin
- JX Lin
- JX She
- JY Djeu
- L Klein
- L London
- L Su
- LA Rubin
- LA Rubin
- Linda S. Wicker
- LKL Jung
- LL Field
- LS Walker
- LS Wicker
- LS Wicker
- M Naranjo-Gomez
- M Ono
- M Rickert
- M Tritt
- M Vukmanovic-Stejic
- MA Atkinson
- MA Williams
- MA Yui
- MF Bachmann
- MJ Lenardo
- MP Neeper
- MP Rubinstein
- N Bottini
- N Kondo
- N Sharfe
- O Boulard
- OJ Brand
- PA Gottlieb
- PA Lyons
- PE Kovanen
- PL Podolin
- PR Burton
- PS Freudenthal
- Q Tang
- QZ Tang
- R del Rio
- R Khattri
- R Setoguchi
- RJ Klose
- RJ Robb
- RP Junghans
- RS Wildin
- S Cha
- S Feau
- S Fisson
- S Gregori
- S Hori
- S Horiuchi
- S Kramer
- S Lindley
- S Nervi
- S Sakaguchi
- S Sakaguchi
- S Sakaguchi
- S Valitutti
- S Wei
- S Wei
- S You
- SL Swain
- SM Pop
- SP Jiang
- SV Kozyrev
- T Brusko
- T Pearson
- TA Chatila
- TIM Tree
- TM Brusko
- TR Malek
- TR Malek
- TR Malek
- TY Roh
- VN Tsytsikov
- WJ Leonard
- WJ Leonard
- X Martinez
- XG Tai
- XQ Wang
- Y Jacques
- Y Minami
- YQ Wu
- ZB Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Observation of triple J/ψ meson production in proton-proton collisions
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim AA
- Abdullah WATW
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- Amendola C
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- Özçelik Ö
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 19/01/2023
- Field of study
Data availability:
Tabulated results are provided in the HEPData record for this analysis71. Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS policy as stated in CMS data preservation, re-use and open access policy.Code availability:
The CMS core software is publically available at https://github.com/cms-sw/cmssw.Copyright . Protons consist of three valence quarks, two up-quarks and one down-quark, held together by gluons and a sea of quark-antiquark pairs. Collectively, quarks and gluons are referred to as partons. In a proton-proton collision, typically only one parton of each proton undergoes a hard scattering – referred to as single-parton scattering – leaving the remainder of each proton only slightly disturbed. Here, we report the study of double- and triple-parton scatterings through the simultaneous production of three J/ψ mesons, which consist of a charm quark-antiquark pair, in proton-proton collisions recorded with the CMS experiment at the Large Hadron Collider. We observed this process – reconstructed through the decays of J/ψ mesons into pairs of oppositely charged muons – with a statistical significance above five standard deviations. We measured the inclusive fiducial cross-section to be 272+141−104(stat)±17(syst)fb, and compared it to theoretical expectations for triple-J/ψ meson production in single-, double- and triple-parton scattering scenarios. Assuming factorization of multiple hard-scattering probabilities in terms of single-parton scattering cross-sections, double- and triple-parton scattering are the dominant contributions for the measured process.SCOAP3.Change history:
27 February 2023A Correction to this paper has been published: https://doi.org/10.1038/s41567-023-01992-
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 07/07/2022
- Field of study
A Correction to this paper has been published (18 October 2023) : https://doi.org/10.1038/s41586-023-06164-8.Data availability:
Tabulated results are provided in the HEPData record for this analysis. Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS data preservation, re-use and open acess policy.Code availability:
The CMS core software is publicly available on GitHub (https://github.com/cms-sw/cmssw).In July 2012, the ATLAS and CMS collaborations at the CERN Large Hadron Collider announced the observation of a Higgs boson at a mass of around 125 gigaelectronvolts. Ten years later, and with the data corresponding to the production of a 30-times larger number of Higgs bosons, we have learnt much more about the properties of the Higgs boson. The CMS experiment has observed the Higgs boson in numerous fermionic and bosonic decay channels, established its spin–parity quantum numbers, determined its mass and measured its production cross-sections in various modes. Here the CMS Collaboration reports the most up-to-date combination of results on the properties of the Higgs boson, including the most stringent limit on the cross-section for the production of a pair of Higgs bosons, on the basis of data from proton–proton collisions at a centre-of-mass energy of 13 teraelectronvolts. Within the uncertainties, all these observations are compatible with the predictions of the standard model of elementary particle physics. Much evidence points to the fact that the standard model is a low-energy approximation of a more comprehensive theory. Several of the standard model issues originate in the sector of Higgs boson physics. An order of magnitude larger number of Higgs bosons, expected to be examined over the next 15 years, will help deepen our understanding of this crucial sector.BMBWF and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, FAPERGS, and FAPESP (Brazil); MES and BNSF (Bulgaria); CERN; CAS, MoST, and NSFC (China); MINCIENCIAS (Colombia); MSES and CSF (Croatia); RIF (Cyprus); SENESCYT (Ecuador); MoER, ERC PUT and ERDF (Estonia); Academy of Finland, MEC, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRI (Greece); NKFIH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); MSIP and NRF (Republic of Korea); MES (Latvia); LAS (Lithuania); MOE and UM (Malaysia); BUAP, CINVESTAV, CONACYT, LNS, SEP, and UASLP-FAI (Mexico); MOS (Montenegro); MBIE (New Zealand); PAEC (Pakistan); MES and NSC (Poland); FCT (Portugal); MESTD (Serbia); MCIN/AEI and PCTI (Spain); MOSTR (Sri Lanka); Swiss Funding Agencies (Switzerland); MST (Taipei); MHESI and NSTDA (Thailand); TUBITAK and TENMAK (Turkey); NASU (Ukraine); STFC (United Kingdom); DOE and NSF (USA). Individuals have received support from the Marie-Curie programme and the European Research Council and Horizon 2020 Grant, contract Nos. 675440, 724704, 752730, 758316, 765710, 824093, 884104, and COST Action CA16108 (European Union); the Leventis Foundation; the Alfred P. Sloan Foundation; the Alexander von Humboldt Foundation; the Belgian Federal Science Policy Office; the Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture (FRIA-Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium); the F.R.S.-FNRS and FWO (Belgium) under the “Excellence of Science – EOS” – be.h project n. 30820817; the Beijing Municipal Science & Technology Commission, No. Z191100007219010; the Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; the Stavros Niarchos Foundation (Greece); the Deutsche Forschungsgemeinschaft (DFG), under Germany’s Excellence Strategy – EXC 2121 “Quantum Universe” – 390833306, and under project number 400140256 - GRK2497; the Hungarian Academy of Sciences, the New National Excellence Program - ÚNKP, the NKFIH research grants K 124845, K 124850, K 128713, K 128786, K 129058, K 131991, K 133046, K 138136, K 143460, K 143477, 2020-2.2.1-ED-2021-00181, and TKP2021-NKTA-64 (Hungary); the Council of Science and Industrial Research, India; the Latvian Council of Science; the Ministry of Education and Science, project no. 2022/WK/14, and the National Science Center, contracts Opus 2021/41/B/ST2/01369 and 2021/43/B/ST2/01552 (Poland); the Fundação para a Ciência e a Tecnologia, grant CEECIND/01334/2018 (Portugal); the National Priorities Research Program by Qatar National Research Fund; MCIN/AEI/10.13039/501100011033, ERDF “a way of making Europe”, and the Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia María de Maeztu, grant MDM-2017-0765 and Programa Severo Ochoa del Principado de Asturias (Spain); the Chulalongkorn Academic into Its 2nd Century Project Advancement Project, and the National Science, Research and Innovation Fund via the Program Management Unit for Human Resources & Institutional Development, Research and Innovation, grant B05F650021 (Thailand); the Kavli Foundation; the Nvidia Corporation; the SuperMicro Corporation; the Welch Foundation, contract C-1845; and the Weston Havens Foundation (USA)
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Precision measurement of the W boson decay branching fractions in proton-proton collisions at √s=13 TeV
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- Zorbilmez C
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- Zuolo D
- Zygala L
- Álvarez CR
- Özçelik Ö
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 26/04/2022
- Field of study
The leptonic and inclusive hadronic decay branching fractions of the W boson are measured using
proton-proton collision data collected at ffiffi s p ¼ 13 TeV by the CMS experiment at the CERN LHC,
corresponding to an integrated luminosity of 35.9 fb−1. Events characterized by the production of one or
two W bosons are selected and categorized based on the multiplicity and flavor of reconstructed leptons, the
number of jets, and the number of jets identified as originating from the hadronization of b quarks. A
binned maximum likelihood estimate of the W boson branching fractions is performed simultaneously in
each event category. The measured branching fractions of the W boson decaying into electron, muon, and
tau lepton final states are ð10.83 0.10Þ%, ð10.94 0.08Þ%, and ð10.77 0.21Þ%, respectively,
consistent with lepton flavor universality for the weak interaction. The average leptonic and inclusive
hadronic decay branching fractions are estimated to be ð10.89 0.08Þ% and ð67.32 0.23Þ%, respec tively. Based on the hadronic branching fraction, three standard model quantities are subsequently derived: the sum of squared elements in the first two rows of the Cabibbo–Kobayashi–Maskawa (CKM) matrix
P ij jVijj 2 ¼ 1.984 0.021, the CKM element jVcsj ¼ 0.967 0.011, and the strong coupling constant at
the W boson mass scale, αSðm2 WÞ ¼ 0.095 0.033
Measurement of the Higgs boson width and evidence of its off-shell contributions to ZZ production
- Author
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- Strait J
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- Strologas J
- Strong G
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- Summers S
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- Yohay R
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- Yoo J
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- Yu GB
- Yu I
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- Yuldashev BS
- Yumiceva F
- Zabi A
- Zacharopoulou A
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
- Zarucki M
- Zecchinelli AG
- Zeinali M
- Zeuner WD
- Zghiche A
- Zhang F
- Zhang H
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- Zhizhin I
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- Zorbilmez C
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Since the discovery of the Higgs boson in 2012, detailed studies of its properties have been ongoing. Besides its mass, its width—related to its lifetime—is an important parameter. One way to determine this quantity is to measure its off-shell production, where the Higgs boson mass is far away from its nominal value, and relating it to its on-shell production, where the mass is close to the nominal value. Here we report evidence for such off-shell contributions to the production cross-section of two Z bosons with data from the CMS experiment at the CERN Large Hadron Collider. We constrain the total rate of the off-shell Higgs boson contribution beyond the Z boson pair production threshold, relative to its standard model expectation, to the interval [0.0061, 2.0] at the 95% confidence level. The scenario with no off-shell contribution is excluded at a p-value of 0.0003 (3.6 standard deviations). We measure the width of the Higgs boson as ΓH=3.2+2.4−1.7MeV, in agreement with the standard model expectation of 4.1 MeV. In addition, we set constraints on anomalous Higgs boson couplings to W and Z boson pairs