An exploratory study on the social and genotypic clustering of HIV infection in men having sex with men

OBJECTIVE: To explore the clustering of HIV infected men having sex with men (MSM) using social network approach in conjunction with the phylogenetic relationship of the virus strains. DESIGN: An exploratory study incorporating social network and phylogenetic analysis. METHODS: Recently diagnosed HIV-infected MSM attending one major HIV specialist clinic in Hong Kong were recruited in the study involving the administration of a self-administered questionnaire on behaviours and partnership patterns using a Likert Scale, the results of which were assessed using social network analysis and in context of the phylogenetic analysis from sequencing the HIV-1 pol gene, as part of the clinical investigation for genotypic resistance. Clusters were defined using social and molecular methods. RESULTS: An 'Internet-centred' cluster and 'Sauna-centred' cluster could be delineated using correspondence analysis and network diagrams. The main distinguishing features of MSM in the 'Internet-centred' social cluster were: younger age, higher education level, and multiple partner types. Three genetic clusters could be identified in the phylogenetic tree, two of which associated with Internet use and one with sauna for sex partnership. There were partial overlaps between social and genetic clusters. Characteristically, the virus strains in sauna users were more disperse compared with the closely knit configuration of those using Internet. CONCLUSION: The principle of the duality of place and person can be strategically applied in epidemiologic investigation. The characterization of MSM cluster using anonymized network data provides a potentially powerful tool for informing public health intervention. © 2009 Lippincott Williams & Wilkins, Inc.postprin

Beyond the therapeutic: a Habermasian view of self-help groups’ place in the public sphere

Self-help groups in the United Kingdom continue to grow in number and address virtually every conceivable health condition, but they remain the subject of very little theoretical analysis. The literature to date has predominantly focused on their therapeutic effects on individual members. And yet they are widely presumed to fulfil a broader civic role and to encourage democratic citizenship. The article uses Habermas’ model of the public sphere as an analytical tool with which to reconsider the literature on self-help groups in order to increase our knowledge of their civic functions. In doing this it also aims to illustrate the continuing relevance of Habermas’ work to our understanding of issues in health and social care. We consider, within the context of current health policies and practices, the extent to which self-help groups with a range of different forms and functions operate according to the principles of communicative rationality that Habermas deemed key to democratic legitimacy. We conclude that self-help groups’ civic role is more complex than is usually presumed and that various factors including groups’ leadership, organisational structure and links with public agencies can affect their efficacy within the public sphere

Problem-based learning in social work: A study of student learning outcomes

This study evaluated the effects of problem-based learning (PBL) in social work education. The participants were 132 second-year social work students who took the core courses of Social Work Theory and Practice and Skills Laboratory in the PBL mode. A 40-item scale was used to measure the students' perceptions of their social work knowledge, skills, and values, Biggs's Study Process Questionnaire and Revised Study Process Questionnaire were employed to examine their learning approaches. The results indicated positive learning outcomes, with the most significant gains occurring in knowledge and lesser gains being made in skills and values. The findings suggest that students with deep learning motives and approaches reap the most benefit from PBL. © 2007 Sage Publications.link_to_subscribed_fulltex

Beyond clinical trials and narratives: A participatory action research with cancer patient self-help groups

The self-help movement in Hong Kong has been gradually gaining its momentum in recent years. The primary purpose of the research was to give voice to the experiences and views of patients towards cancer care and to influence healthcare providers and policy makers to act on patients' agendas. Self-help groups and their members are mobilized through the research activities of focus groups, interviews and a patient forum to specify and act on their needs. This article describes the project and the participatory action research (PAR) strategies in the mobilization of, and collaboration with, patient groups in research design, data analysis, and dissemination of findings. The implications on healthcare practice, particularly within an era of reform and restructuring of the healthcare system, are discussed. © 2005 Elsevier Ireland Ltd. All rights reserved.link_to_subscribed_fulltex

Competing philosophies in the classroom: A challenge to Hong Kong teachers

The present paper examines the experiences of teachers in teaching children with special needs in mainstream schools and how they see and evaluate the feasibility of the new integration initiatives in Hong Kong. The data are based on individual and focus group interviews with general class teachers, resource class teachers and principals of mainstream schools admitting students with special needs. Teachers reported difficulties and problems in maintaining classroom discipline and ambivalence in meeting the competing demands between students with and without special needs. The structural constraints of implementing a rigidly defined curriculum and being accountable for good academic results regardless of student competence pose formidable obstacles in achieving the goals of integrated education. There is a conflict at the systemic level between the philosophy of academic excellence defined by grades on the one hand and the philosophy of equality and inclusion on the other. Improving parent participation, having an ample supply of funds, the provision of necessary equipment and facilities, the availability of pre- and in-service training to teachers, and additional manpower in counselling are the most urgently needed resources in facilitating teachers to engage in teaching students with special needs alongside others.link_to_subscribed_fulltex

Specific activation of photosensitizer with extrinsic enzyme for precisive photodynamic therapy

Title on author’s file: Bioorthogonal Activation of Photosensitizer with Extrinsic Enzyme for Precisive Photodynamic Therapy202305 bcchAccepted ManuscriptRGCPublishe

Preparing social workers to be lifelong learners: Use of problem-based learning as a training component in the social work curriculum

A constant concern for educators is how best to train the students. With the knowledge explosion and increasing complexity of the social problems, we have to look for ways to strengthen social work students' ability for continual development. Enhancing their lifelong learning competence would help them to face the future demands. To achieve this, the University of Hong Kong Department of Social Work and Social Administration ventured to use the problem-based learning (PBL) approach in some Year two practice courses of the Bachelor of Social Work program. This paper reports on the findings and shares some reflection on the experience. Copyright © 2006 by The Haworth Press, Inc. All rights reserved.link_to_subscribed_fulltex

Self-administered instrument to measure the patient's experience of recovery after first-episode psychosis: Development and validation of the Psychosis Recovery Inventory

Objective: Patients who are recovering from a first-episode psychosis face specific and complex issues that are related to their illness and treatment experiences, such as the appraisal of the extent of their recovery and the risk of relapse. Currently, no instrument provides a comprehensive assessment of these related attitudes. A novel self-administered rating scale for the measurement of key perceptions during the recovery stage after a first-episode psychosis is presented. The Psychosis Recovery Inventory (PRI) is designed to specifically address a number of closely related issues that are faced by patients who are recovering from a first-episode psychosis. Method: The process of development of the PRI involved the generation of items from qualitative interviews, the construction and refinement of these items and a validation study. The longitudinal stability of the PRI items was assessed in a test-retest reliability study in which 20 patients completed the retest within 4 weeks. The internal consistency and convergent validity of the PRI were evaluated by a comparison of the PRI subscale scores and the Scale to Assess Unawareness of Mental Disorder and Drug Attitude Inventory scores in a sample of 48 first-episode psychosis patients. Results: The validation study shows that the PRI is an instrument with a good test-retest reliability, internal consistency and convergent validity. Conclusions: This pragmatic, low burden, self-administered scale can be applied in clinical and research settings to obtain reliable information on the attitudes of patients on a range of interrelated issues in the recovery stage that follows a first-episode psychosis.link_to_subscribed_fulltex

One-pot peptide cyclisation and surface modification of photosensitiser-loaded red blood cells for targeted photodynamic therapy

202209_bcwwRGCPublished12 month

One-pot synthesis of a cyclic antimicrobial peptide-conjugated phthalocyanine for synergistic chemo-photodynamic killing of multidrug-resistant bacteria

Dr. Clarence T. T. Wong, affiliated with the Hong Kong Polytechnic University at the time of final publication.202204 bcfcAccepted ManuscriptRGCPublishe