13 research outputs found
Segmental Ileal Dilatation With Supernumerary Intestinal Muscle Coat In A Neonate
Segmental intestinal dilatation (SID) is a rare developmental anomaly of the midgut, characterized by sharply demarcated dilatation of a gastrointestinal segment with clinical findings of intestinal obstruction. Although morphologic criteria for SID are clearly delineated, etiological origin of dilated intestine is unknown. Histology of the resected segment is usually reported to have normal presence of ganglion cells in the myenteric and submucosal plexuses. Intestinal muscle is hypertrophied, and heterotopic gastric mucosa may also be encountered. A 3-day-old male infant presenting with clinical findings of intestinal obstruction was diagnosed to have SID and had supernumerary intestinal muscle coat (SIMC) in the dilated segment, without any evidence of neurological abnormality. Histopathological findings of the resected ileal segment are reported to discuss the role of architectural malformation of muscularis propria as a cause of SID.PubMe
Voice characteristics of acromegaly
Acromegaly’s effect on voice is still indefinite.
We aimed to define acoustic characteristics of patients with
acromegaly. Cross-sectional case–control study was
designed. Thirty-seven patients with acromegaly and 30
age- and sex-matched healthy controls were included.
Fundamental frequency (F0) and measurements related to
frequency, amplitude, noise and tremor of the obtained
voice sample were analyzed using Multi-Dimensional
Voice Program. Absolute jitter (Jita) and jitter percent
(Jitt), shimmer in decibel and shimmer percent, noise to
harmonic ratio and soft phonation index, fundamental
frequency tremor frequency and frequency tremor intensity
index represented the parameters related to frequency,
amplitude, noise and tremor of the voice sample, respectively.
Patients with acromegaly, especially the uncontrolled
patients, exhibited significant differences in
frequency perturbation measurements. Jitt of all patients
and Jita of uncontrolled patients were significantly higher
than that of control group (p = 0.044 and p = 0.043,
respectively). Jitter which is a measure of frequency perturbation
can be assumed as an indicator of hoarse and
deepened voice. Jita of all patients and Jitt of uncontrolled
patients were elevated, but not reaching a statistical significance.
Controlled and active patients had similar analysis
of acoustic parameters. In the correlation analysis,
shimmer and IGF-1 (insulin like growth factor 1) was
found to be positively correlated in all patients with acromegaly
and in female patients. When the p value is
adjusted according to Bonferroni correction regarding the
use of ten parameters for acoustic analysis (so adjusted p is
\0.005), all the statistically significant findings become
insignificant. Considering the parameters test different
properties of voice, it is reasonable to pay attention to the
findings. Patients with acromegaly have increased frequency
perturbations measures, but this increase is nonsignificant
according to Bonferroni correction. This may be
perceptually sensed as hoarse voice. Amplitude perturbations
within the voice of the patients with acromegaly are
positively correlated with IGF-1 levels, this correlation is
also non-significant according to Bonferroni correction