13 research outputs found
A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation
Establishing causal links between inherited polymorphisms and cancer risk is challenging. Here, we focus on the single-nucleotide polymorphism rs55705857, which confers a sixfold greater risk of isocitrate dehydrogenase ((IDH)-mutant low-grade glioma (LGG). We reveal that rs55705857 itself is the causal variant and is associated with molecular pathways that drive LGG. Mechanistically, we show that rs55705857 resides within a brain-specific enhancer, where the risk allele disrupts OCT2/4 binding, allowing increased interaction with the (Myc) promoter and increased (Myc) expression. Mutating the orthologous mouse rs55705857 locus accelerated tumor development in an Idh1(R132H)-driven LGG mouse model from 472 to 172 days and increased penetrance from 30% to 75%. Our work reveals mechanisms of the heritable predisposition to lethal glioma in ~40% of LGG patients
Plantas com possĂvel atividade hipolipidĂȘmica: uma revisĂŁo bibliogrĂĄfica de livros editados no Brasil entre 1998 e 2008 Plants with possible hypolipidemic activity: a review of books published in Brazil between 1998 and 2008
O objetivo deste trabalho foi realizar levantamento sobre as plantas medicinais indicadas para o tratamento da hiperlipidemia, hipercolesterolemia e/ou aterosclerose. Este estudo foi feito a partir da pesquisa bibliogrĂĄfica em 32 livros publicados no Brasil entre 1998 e 2008, resultando em lista de 85 espĂ©cies distribuĂdas em 53 famĂlias, principalmente Asteraceae e Fabaceae, com 54 espĂ©cies exĂłticas e 31 nativas. As espĂ©cies mais citadas foram Allium sativum (Alliaceae), Cynara scolymus (Asteraceae), Curcuma longa (Zingiberaceae), Allium cepa (Alliaceae), Echinodorus grandiflorus (Alismataceae), Taraxacum officinale (Asteraceae), Vernonia condensata (Asteraceae), Cuphea carthagenensis (Lythraceae) e Curcuma zedoaria (Zingiberaceae). As espĂ©cies nativas, citadas em pelo menos 2 livros, foram investigadas para alguma evidencia cientĂfica relacionada a possĂveis efeitos hipolipidĂȘmico, hipocolesterolĂȘmico e/ou contra aterosclerose. Somente foram encontrados estudos cientĂficos, relacionados a estes efeitos, para as espĂ©cies nativas Cuphea carthagenensis e Echinodorus grandiflorum, indicando a necessidade de pesquisas que possam garantir a segurança e a eficĂĄcia do uso destas espĂ©cies.<br>The aim of this study was to survey medicinal plants indicated for the treatment of hyperlipidemia, hypercholesterolemia and/or atherosclerosis. This study was performed from a review of 32 books published in Brazil between 1998 and 2008, resulting in a list of 85 species belonging to 53 families, especially Asteraceae and Fabaceae, with 54 exotic and 31 native species. The species most often cited were Allium sativum (Alliaceae), Cynara scolymus (Asteraceae), Curcuma longa (Zingiberaceae), Allium cepa (Alliaceae), Echinodorus grandiflorus (Alismataceae), Taraxacum officinale (Asteraceae), Vernonia condensata (Asteraceae), Cuphea carthagenensis (Lythraceae) and Curcuma zedoaria (Zingiberaceae). Native species cited in at least 2 books were investigated for some scientific evidence related to possible hypolipidemic and hypocholesterolemic effects and/or action against atherosclerosis. Scientific studies related to these effects were found only for the native species Cuphea carthagenensis and Echinodorus grandiflorum, indicating the need for studies capable of assuring the safety and the efficacy as to the use of these species
Decay studies in the AâŒ225 Po-Fr region from the DESPEC campaign at GSI in 2021
International audienceThe HISPEC-DESPEC collaboration aims at investigating the structure of exotic nuclei formed in fragmentation reactions with decay spectroscopymeasurements, as part of the FAIR Phase-0 campaign at GSI. This paper reportson first results of an experiment performed in spring 2021, with a focus on ÎČ-decaystudies in the Po-Fr nuclei in the 220 <A< 230 island of octupole deformationexploiting the DESPEC setup. Ion-beta correlations and fast-timing techniques arebeing employed, giving an insight into this difficult-to-reach region