Accessible interactive digital signage for visually impaired

In this workshop we discuss the potential of cross-modal haptic-auditory feedback for empowering visually impaired people to experience Interactive Digital Signage

PROCEDURAL MODELLING FOR HBIM OF ITALIAN RAILWAYS IRON BRIDGES

Abstract. The development of the railways network in the 19th century represented a significant scenario for the technological advancement of the entire Italian building sector; consequently, it produced a relevant renewal of construction techniques. Icons of this robust infrastructure building program were the railway bridges built over the Po river; their construction represented an arduous technological challenge. Unfortunately, in the years following the proclamation of the Kingdom of Italy the national industry was disorganized and unprepared to face this ambitious challenge; indeed, the first four bridges were built by foreign companies that could guarantee the necessary technological know-how. However, the industrial scenario immediately changed and the last two bridges were designed and built by Italian engineers and steelwork companies. The railway bridges over the River Po are now lost; the changing needs of railway traffic or bombings during the Second World War unavoidably led to their demolition. Their enhancement through 3d modelling and virtual representation is fundamental for the rediscovering of the role they played not only in the construction of the national infrastructural system but also in the life of the young state. To this aim, the paper proposes the outcomes of research that explores the potentialities of 3d software with Visual Programming Language (VPL), in order to create modelling tools useful for the disclosure and dissemination of the historical value of this lost heritage

THE LOST HERITAGE OF ROMAN IRON AND STEEL BRIDGES. VIRTUAL RECONSTRUCTION OF TWO CASE STUDIES

Abstract. In the second half of 19th century the city of Rome knew a period of great urban transformations: the Pope Pio IX and after, the government of the new Kingdom of Italy, strongly pushed the modernization of the ancient and underdeveloped city, trying to follow the examples of the main European capitals. One of the most relevant signs of that period was the construction of multiple iron and steel bridges along the Tiber, that were built to improve the crossing network guaranteed by the old masonry links. Different supporting systems were used and many experimental technologies for the Italian context were tested, representing a crucial phase for the settle of a design and an industrial know-how that was firstly imported from the most advanced countries of the Northern Europe. In the 20th century most of these connections were unfortunately replaced, losing this precious heritage which was strongly linked to the technological culture of the time. Garibaldi Bridge, still present but radically transformed, and Alari Bridge, completely demolished, have been accurately modelled thanks to the availability of appropriate archival documentation and on-site tests, applied following a proposed methodology. The virtual reconstruction of the two case studies permits to spread the knowledge of this lost heritage, to ease the divulgation of past technologies and to recover the unusual image of exposed iron and steel structures surrounded by the ancient panorama of the Eternal city.</p

HBIM AND THE 20TH CENTURY STEEL BUILDING HERITAGE – A PROCEDURE SUITABLE FOR THE CONSTRUCTION HISTORY IN ITALY

Abstract. The use of steel technologies in Italian architecture still represents an unexplored field of research, characterised by limited and fragmented episodes that reveal important design experimentations and relevant architectural results of the 20th century. For this reason, the aim of the research consists of defining a HBIM methodological approach addressed to the study of modern steel architectures, considering their specific features and their hybrid constructive nature. Indeed these buildings are often characterized by a high level of industrial production of building components merged with the recovery of a craftsmanship tradition, particularly appearing at the scale of structure and envelope details. The balance between standardization and traditional techniques in production processes, leads to the definition of a HBIM method composed of three steps: an operational tools for existing buildings of 20th century made of steel that could support the construction of building digital archives, the organisation of maintenance programs and possible transformative actions, avoiding the loss of this heritage sometimes caused by bad interventions that deeply change original and valuable features of these architectures.</p

Mixed trichuroid infestation in a dog from Italy

Background: Capillaria aerophila, Capillaria boehmi and Trichuris vulpis are trichuroid nematodes affecting wild and companion animals all over the World. The canine intestinal whipworm, T. vulpis, is the most common and wellknown in veterinary practice, whereas the respiratory C. aerophila and C. boehmi have been rarely reported in pets as a likely consequence of overlapping morphometric and morphological features of the eggs, which impair a correct etiological diagnosis. Findings: In December 2011, a mixed infestation by T. vulpis, C. aerophila and C. boehmi was diagnosed in an asymptomatic dog living in central Italy. Morphometric and morphological findings and pictures of the eggs found at the copromicroscopic analysis are herein reported. Conclusions: The present work demonstrates that when trichuroid eggs are found in a faecal sample from a dog, a careful morphological and morphometric analysis of individual parasite elements is mandatory. Key diagnostic features (i.e., size, wall surface pattern and aspects of plugs) should be carefully examined when eggs with overlapping shape and appearance are detected. In conclusion, given the importance in clinical practice of canine trichuroids and the zoonotic potential of C. aerophila, these nematodes should be included into the differential diagnosis of intestinal and respiratory parasitoses of dogs by a thorough microscopic analysis of all trichuroid ova present in microscopic fields

Efficacy and toxicity of bevacizumab in recurrent ovarian disease: an update meta-analysis on phase III trials

Background: To analyze the efficacy and toxicity of bevacizumab on survival outcomes in recurrent ovarian cancer. Results: Bevacizumab was associated with significant improvement of PFS and OS compared with standard treatment with HRs of 0.53 (95% CI 0.44 - 0.63; p &lt; 0.00001) and 0.87 (95% CI, 0.77 to 0.99; p = 0.03), respectively. Bevacizumab increased the incidence of G3/G4 hypertension (RR 19.01, 95% CI 7.77 - 46.55; p &lt; 0.00001), proteinuria (RR 17.31, 95% CI 5.42 - 55.25; p &lt; 0.00001), arterial thromboembolic events (ATE) (RR 4.99, 95% CI 1.29 - 19.27; p = 0.02) and bleeding (RR 3.14, 95% CI 1.35 - 7.32; p = 0.008). Materials and Methods: Three randomized phase III trials representing 1502 patients were identified. Pooled hazard ratio (HR), odd ratio (OR), risk ratio (RR) with 95% confidence interval (CI) were calculated using fixed or random effects model. Conclusions: Adding bevacizumab to standard chemotherapy improved ORR, PFS and OS, and it had a higher, but manageable, incidence of toxicities graded 3 to 4

Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control

Dopamine (DA) is a key neurotransmitter involved in multiple physiological functions including motor control, modulation of affective and emotional states, reward mechanisms, reinforcement of behavior, and selected higher cognitive functions. Dysfunction in dopaminergic transmission is recognized as a core alteration in several devastating neurological and psychiatric disorders, including Parkinson's disease (PD), schizophrenia, bipolar disorder, attention deficit hyperactivity disorder (ADHD) and addiction. Here we will discuss the current insights on the role of DA in motor control and reward learning mechanisms and its involvement in the modulation of synaptic dynamics through different pathways. In particular, we will consider the role of DA as neuromodulator of two forms of synaptic plasticity, known as long-term potentiation (LTP) and long-term depression (LTD) in several cortical and subcortical areas. Finally, we will delineate how the effect of DA on dendritic spines places this molecule at the interface between the motor and the cognitive systems. Specifically, we will be focusing on PD, vascular dementia, and schizophrenia