Biased diffusion in a piecewise linear random potential

We study the biased diffusion of particles moving in one direction under the action of a constant force in the presence of a piecewise linear random potential. Using the overdamped equation of motion, we represent the first and second moments of the particle position as inverse Laplace transforms. By applying to these transforms the ordinary and the modified Tauberian theorem, we determine the short- and long-time behavior of the mean-square displacement of particles. Our results show that while at short times the biased diffusion is always ballistic, at long times it can be either normal or anomalous. We formulate the conditions for normal and anomalous behavior and derive the laws of biased diffusion in both these cases.Comment: 11 pages, 3 figure

Значение создания фармацевтической системы качества на предприятиях по выпуску лекарственных средств в контексте построения единого фармацевтического рынка ЕАЭС

The publication discusses the theoretical and regulatory aspects of a pharmaceutical quality system (PQS) design at the manufacturers, including its discussion through the prism of historical and foreign experience, and specifies the significance of single PQS design for the formation of the EAEU single pharmaceutical market. It is substantiated that the quality assurance of pharmaceutical products under current conditions should be based on an integral approach, the most important element of which is PQS, universal guidelines contained in the current GMP regulations. The authors propose the solutions of the problem, among which an important role is played by the further harmonization of PQS requirements and the unification of management and control systems in the market.В публикации рассматриваются теоретические и нормативно-правовые аспекты создания фармацевтической системы качества (ФСК) на предприятиях, в том числе через призму исторического и зарубежного опыта, и уточняется значимость для построения единой ФСК формирования единого фармацевтического рынка ЕАЭС. Обосновывается, что обеспечение качества фармацевтической продукции в современных условиях должно основываться на интегральном подходе, важнейшим элементом которого выступают ФСК, универсальные рекомендации, содержащиеся в актуальных руководящих документах по надлежащей производственной практике (GMP). Предлагаются направления решения проблемы, среди которых важное место отводится дальнейшей гармонизации требований к ФСК и унификации систем управления и контроля на рынке

Congenital anemia: a diagnostic algorithm

A.L. Zaplatnikov1, M.N. Podzolkova1, M.A. Ponimanskaya2, Yu.V. Denisova1, A.V. Dmitriev3, A.A. Dement’ev1, Zh.L. Chabaidze1, D.N. Smirnov1 1Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation 2F.I. Inozemtsev City Clinical Hospital, Moscow, Russian Federation 3Ryazan State Medical University, Ryazan, Russian Federation Congenital anemia is one of the major interdisciplinary problems of modern medicine. The aim of this publication is to outline the current concepts of early diagnosis of congenital anemia for their introduction in obstetric care practices. As a result, it will be possible to improve the disease prognosis and, in general, to reduce perinatal losses. Congenital anemias include those developed in the ante- and/or intranatal period. The main causes of congenital anemia comprise fetal blood loss, severe forms of intrauterine infections and hemolytic disease of the fetus. It is specified that the most common cause of congenital anemia is fetal blood loss. Prenatal fetal blood loss can be categorized as transplacental (fetal-maternal), intraplacental, retroplacental, fetal-fetal (in case of multifetal monochorionic pregnancy) and iatrogenic (rare complications of the invasive methods of patient examination and treatment). Fetal blood loss during delivery may be caused by var ious damages and/or disorders of the umbilical cord (rupture, hematoma) and/or the placenta (placental presentation or abruption, chorioangioma, etc.), as well as hemorrhages and bleedings (intracranial, into internal organs, etc.) of the fetus in case of abnormal labor and/or severe hypoxia. The article highlights the current verification criteria of congenital anemia and an algorithm of its diagnosis. Keywords: anemia, immune hydrops fetalis, intrauterine infections, congenital anemia, complete blood count, fetal blood loss, non-immune hydrops fetalis, newborn infant, posthemorrhagic anemia. For citation: Zaplatnikov A.L., Podzolkova M.N., Ponimanskaya M.A. et al. Congenital anemia: a diagnostic algorithm. Russian Journal of Woman and Child Health. 2022;5(4):358–365 (in Russ.). DOI: 10.32364/2618-8430-2022-5-4-358-365. <br