4,061 research outputs found
Paolo di Tarso nella filosofia del Novecento. Heidegger, Jonas, Taubes, Rosenzweig.
In questo lavoro mi sono impegnato ad analizzare l'uso che la filosofia del Novecento, per ri-pensare le sue categorie, fa dell'esperienza religiosa del cristinesimo delle origini, così come essa è desunta dalla nuova analitica esistenziale dell'epistolario paolino. Se Heidegger è il primo autore incluso nel nostro ragionamento, l'obiettivo insito in quest'ultimo è andare oltre la sua proposta filosofica per non esaurire in essa le possibilità che la riscoperta dell'esperienza religiosa di Paolo di Tarso può significare per il pensiero novecentesco. Se quindi Heidegger ricaverà da un Paolo fortemente antigiudaico e anticosmico quell'escatologia scevra di eschaton caratteristica delle pagine di Essere e tempo, attraverso autori come Jonas e Taubes, alla ricerca invece di un'ebraicità costitutiva del cristianesimo e dell'escatologia paolina, giungeremo fino all'alternativa ermeneutica rappresentata invece da Franz Rosenzweig. Quest'ultimo, nel segno di una lettura della divisione fra cristiani ed ebrei in Paolo come uno spazio per una relazione fra questi due mondi, riuscirà a suggerirci un nuovo pensiero di Eternità accanto al nuovo sentire del tempo ri-scoperto da Heidegger
A case study for spacegate point-to-point transportation: Evaluation of a reference end-to-end mission operations and assessment of the associated safety aspects
The ALTEC-conducted Spacegate feasibility study addresses the opportunities offered by the sub-orbital flight with special emphasis to future generation transportation. Pursuing the same systemic methodology of the initial Spacegate definition activities, this paper focuses on some specific aspects of suborbital operations and outlines a top level end-to-end operating cycle for a reference suborbital mission spanning from pre-flight, to flight, re-entry and post landing operations and associated Ground Segment. Special focus is given to identification of suitable locations in Italy for suborbital operations, and to liftoff and re-entry phases; the results of specific simulations are also reported, showing some lift off options and the feasibility of the spiral shaped descent maneuver that improves the pilot controllability of the vehicle during the re-entry phase. Further, this paper outlines within the selected reference mission, the main safety aspects considered as driving factors in planning and implementing future generation transportation; areas such as launch/landing range and relevant risk management/mitigation policies, as well as selection of safety driving criteria in the definition of trajectories and space transition corridors, and capabilities to monitor the vehicle ascent and re-entry will be assessed. Safety regulations will also be evaluated to protect launch range, drive spaceport site selection and consequently the ability of the spaceport to accommodate large numbers of passengers and participants, as well as a number of simultaneous operations such as training, vehicle integration tasks, and passenger preparation for flight. For human flight in general, and in particular for commercial point to point activities at this early stage, it is vital to minimize risk since a fatal accident at the very beginning of flights will put the entire business in jeopardy. The regulatory challenges with regards to safety will also be outlined in this paper, related to executing Spacegate activities in Europe and collaborations with the involved Agencies in the USA and Europe (FAA, ENAC, ENAV, SESAR, EASA) will be explored; in particular, some initiatives have already been started, that include active ALTEC participation to the IAASS Space Safety Technical Committee (SSTC) that was created to contribute to the advancement of the Safety in the area of the "Commercial Suborbital Flight"
modelling of acoustic ageing of rubberized pavements
Abstract Tyre-road noise is the most important source of traffic noise in the mid-to-high speed range. The use of low noise road surfaces represents an ideal solution to mitigate traffic noise, because it directly affects the source, generating a widespread benefit for all the dwellings near the road and decreasing the number of people annoyed. More knowledge about long-term acoustic performance is required to promote the use of low noise road surfaces as mitigation action. In fact, as for a traditional road surface, the acoustic properties of low noise surfaces worsen over time: only by knowing the initial noise reduction and its time evolution, public administrations can design their application and related maintenance plans. In this work, an innovative approach was used to investigate and model acoustic ageing of some rubberized road surfaces surveyed for several years. This type of quiet pavements represents an efficient road surface technology in terms of traffic noise reduction. A new regression model was applied to estimate the acoustic ageing of the investigated pavements, considering the complex interacting system composed of three main elements: pavement type, traffic loads and climatic conditions
Relationship between tyre cavity noise and road surface characteristics on low-noise pavements
Abstract In this work, a protocol to study Tyre Cavity Noise (TCN) was developed. Using this new method, TCN was measured on 24 different road pavements, together tyre noise emission measured with the Close-Proximity (CPX) method and road texture measurements. The results were used to model the relationship between TCN and road surface parameters. The analysis shows that the Standard Reference Test Tyre's (SRTT) TCN is correlated to megatexture at low frequencies and that the correlation between TCN and outside noise emission is significant for frequencies lower than 1 kHz. The use of sensors placed inside the tyre for monitoring the acoustic performance of road pavements presents several advantages compared to the CPX method, such as a more compact design, lower cost and lower hazards both for the instrumentation and for other vehicles
Impact of monotherapy on HIV-1 reservoir, immune activation, and co-infection with Epstein-Barr virus
Abstract
Objectives
Although monotherapy (mART) effectiveness in maintaining viral suppression and CD4 cell count has been extensively examined in HIV-1-infected patients, its impact on HIV-1 reservoir, immune activation, microbial translocation and co-infection with Epstein-Barr Virus (EBV) is unclear.
Methods
This retrospective study involved 32 patients who switched to mART; patients were studied at baseline, 48 and 96 weeks after mART initiation. Thirty-two patients who continued combined antiretroviral therapy (cART) over the same period of time were included in the study. Markers of HIV-1 reservoir (HIV-1 DNA and intracellular HIV-1 RNA) were quantified by real-time PCR. Markers of T-(CD3(+)CD8(+)CD38(+)) and B-(CD19(+)CD80/86(+) and CD19(+)CD10-CD21(low)CD27(+)) cell activation were evaluated by flow cytometry. Plasma levels of microbial translocation markers were quantified by real-time PCR (16S ribosomal DNA and mitochondrial [mt] DNA) or by ELISA (LPS and sCD14). EBV was typed and quantified by multiplex real-time PCR.
Results
At baseline, no differences were found between mART and cART groups. Three (10%) mART-treated patients had a virological failure vs none in the cART group. Levels of HIV-1 DNA, intracellular HIV-1 RNA and EBV-DNA remained stable in the mART group, while decreased significantly in the cART group. Percentages of T-and B-activated cells significantly increased in the mART-treated patients, while remained at low levels in the cART-treated ones (p = 0.014 and p<0.001, respectively). Notably, levels of mtDNA remained stable in the cART group, but significantly rose in the mART one (p<0.001).
Conclusions
Long-term mART is associated with higher levels of T-and B-cell activation and, conversely to cART, does not reduce the size of HIV-1 reservoir and EBV co-infection
Influence of texture on tyre road noise spectra in rubberized pavements
Abstract Road traffic noise is the most common source of environmental pollution in urban areas and therefore, the study of noise mitigation actions is fundamental for urban planning. The main source of road traffic noise is tyre/road interaction; thus, the use of low noise road surfaces represents an optimal solution for its mitigation. Several studies tried to find a correlation between road texture and broadband noise data, trying to provide guidelines for the development of acoustically optimised road surfaces. The present work studies the correlation between road texture and tyre/road noise from an experimental point of view, by analysing texture and noise spectra on ten different road surfaces. Tyre deformation has also been addressed by analysing two already existing tyre envelopment algorithms. The first algorithm, proposed by Von Meier and based on the limitation of the second order derivative of the profile signal, shows poor correlation with high frequency noise, while the second algorithm, based on a novel method proposed by Sandberg and Goubert and called indenter method, enhances correlation with low frequency noise and preserves information at higher frequencies. Correlation patterns show that rolling noise can be separated in three main contributions: low, middle and high frequency noise. Finally, experimental tyre/road noise and enveloped texture data obtained with the indenter algorithm have been used to elaborate a linear model that relates low and high frequency noise to texture one-third octave bands. This model deepens knowledge on tyre/road interaction
The EMAS Registration of the Livenza Furniture District in the Province of Pordenone (Italy)
Abstract: One of the most important manufacturing areas of the Friuli Venezia Giulia region is the territory close to Pordenone, the Livenza furniture district. This industrial district, consisting of industries of wood, wood and cork products, furniture, straw articles, and weave materials, located in 11 municipalities of that area, was the \ufb01rst Italian district to obtain the Eco-Management and Audit Scheme (EMAS) Registration in 2006. Data and information from a questionnaire compiled by more than 100 \ufb01rms and 11 municipalities of the district were used to draw up the territorial environmental analysis (TEA). For the EMAS registration renewal, obtained in 2016, the TEA was updated by reviewing the methodology of the environmental impact evaluation: the ecological footprint(EF)wascomparedwiththecarryingcapacity(CC)ofthatarea. Theresultsputinlightthat theEFwasgreaterthantheCC.Severalactionsforreducingtheenvironmentalimpactsofthedistrict activities were highlighted
The EMAS Recognition of the Livenza Furniture District in the Province of Pordenone (Italy)
The EC Regulation No 761/2001, known as EMAS II, provided the possibility of obtaining the EMAS recognition also by industrial districts. As a consequence, the Livenza furniture district obtained the EMAS recognition in 2006 as the first industrial district in Italy. The Livenza district includes several manufacturing enterprises which carry out their activity in 11 municipalities of the province of Pordenone, Italy. Industries of wood, wood and cork products, straw articles, weave materials and furniture take part in the district. A Territorial Environmental Analysis was drawn up to obtain the recognition, by collecting data and information from questionnaires compiled by more than 100 firms and by the 11 municipalities of the district. For the EMAS registration renewal, obtained by the district in 2016, the Territorial Environmental Analysis was updated by revising in particular the methodology of evaluation of environmental impacts. More specifically, Ecological Footprint (EF) (that is, the quantitative evaluation of consumption of raw materials and energy and of waste production) was compared with Carrying Capacity (CC) (that is, the quantitative evaluation of the area able to assure the availability of the resources required and to absorb waste produced). In this way, it was possible to put in light that the EF of the district is much greater than the corresponding CC. The main actions which might be chosen to reduce EF have been pinpointed, with the aim of warranting a better sustainability of the district activities
modelling the acoustic performance of newly laid low noise pavements
Abstract Road traffic in urban contexts produces noise mainly by the interaction of tyres with pavement surface and, therefore, the use of low-noise surfaces represents the best solution since they aim to mitigate the source. Moreover, in urban contexts it is often the only viable solution, together with a careful traffic planning. The main challenge in their adoption as noise mitigation actions is to be able to forecast the acoustical performances that the new road surface will be able to offer. In the UE, the new Green Public Procurement requires experimental verification of noise performance compliance: the designer must declare the acoustical performance of the proposed low-noise pavement and, a few months after the laying, the actual performance of the road surface must be tested using the Close Proximity Method (CPX). Due to the importance of being able to forecast CPX levels, the present work reports a novel way to model CPX broadband levels of newly laid low-noise road surfaces using only data available to the designer before the laying or easily obtained through coring tests, such as grading curve, fractal dimension, asphalt binder content, air voids, voids in mineral aggregates. Two models were elaborated, using two different frequency separations for tyre/road noise. The first model separates low and high frequency contributions, while the second one also considers noise around 1 kHz separately, using a three-band model. Both models are capable of forecasting the acoustic performance of newly laid low-noise road surfaces, using different road mixture parameters at different frequency ranges. The three band model shows a lower RMSE
evaluation of tyre road noise and texture interaction on rubberised and conventional pavements using cpx and profiling measurements
Road traffic noise is the most common source of environmental pollution in urban areas, and therefore, the study of noise mitigation actions is fundamental for urban planning. The use of low noise ..
- …