Formes cliniques de la sarcoïdose au diagnostic (étude monocentrique rétrospective de 41 observations recueillies en médecine interne)

MONTPELLIER-BU Médecine UPM (341722108) / SudocPARIS-BIUM (751062103) / SudocMONTPELLIER-BU Médecine (341722104) / SudocSudocFranceF

Vitamine B6 et maladie thrombo-embolique veineuse

MONTPELLIER-BU Médecine UPM (341722108) / SudocPARIS-BIUM (751062103) / SudocMONTPELLIER-BU Médecine (341722104) / SudocSudocFranceF

Signification de la ferritinémie au cours du syndrome inflammatoire (étude rétrospective de trente-six patients vus pendant un an dans le service de Médecine interne de l'hôpital d'Auch)

Une étude rétrospective a été menée sur trente-six patients vus entre Septembre 2005 et Septembre 2006 dans le service de Médecine interne de l'hôpital d'Auch visant à montrer une corrélation entre un syndrome inflammatoire biologique, la ferritinémie et l'orientation diagnostique au cours de l'enquête étiologique. Il apparaît qu'un syndrome inflammatoire biologique associé à une hyperferritinémie est le plus souvent dû à une pathologie inflammatoire ou infectieuse, d'autant plus que l'inflammation clinique et biologique est marquée. A contrario, un syndrome inflammatoire biologique accompagné par une ferritinémie normale ou basse est lié à une néoplasie d'autant plus que l'inflammation est fruste, que l'anémie est profonde et que les signes cliniques généraux sont pauvres. On retiendra enfin que le dosage du récepteur soluble de la transferrine est le meilleur outil actuel permettant d'évaluer le statut martial au cours de l'inflammation.TOULOUSE3-BU Santé-Centrale (315552105) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Study of the influences of film processing conditions and glycerol amount on the water sorption and gas barrier properties of novel sodium caseinate films

International audienceThis study deals with water sorption characteristics and gas barrier properties of sodium caseinate based edible films as a function of processing type and processing additives. Two processing routes are adopted: solution casting and blown-film-extrusion. Two processing additives are used: glycerol as plasticizer and ethanol as protein denaturing agent. It is shown at first that the water and gas transport properties are neither affected by the processing technology nor by the use of ethanol during the fabrication step. Water sorption and thermal properties of blown films prepared for glycerol contents varying from 15 to 25 wt% are then studied for a wide range of relative humidity. The determination of the water sorption isotherms and their modeling by Park's equation as well as the study of the water sorption kinetics parameters allow discussing the sorption mechanisms as a function of the respective plasticizing effect of glycerol and water, on one hand and of the ability of water molecules to form clusters within the material, on the other hand. The decrease of the glass transition temperature values of the films as a function of increasing water content is analyzed thanks to Gordon-Taylor equation and it is related to the respective plasticizing role of glycerol and water, as evidenced from water sorption analysis

Antimicrobial Activity of Nisin and Natamycin Incorporated Sodium Caseinate Extrusion-Blown Films: A Comparative Study with Heat-Pressed/Solution Cast Films

International audienceAntimicrobial edible films based on sodium caseinate, glycerol, and 2 food preservatives (nisin or natamycin) were prepared by classical thermomechanical processes. Food preservatives were compounded (at 65 degrees C for 2.5 min) with sodium caseinate in a twin-screw extruder. Anti-Listeria activity assays revealed a partial inactivation of nisin following compounding. Thermoplastic pellets containing food preservatives were then used to manufacture films either by blown-film extrusion process or by heat-press. After 24 h of incubation on agar plates, the diameters of K. rhizophila growth inhibition zones around nisin-incorporated films prepared by solution casting (control), extrusion blowing or heat pressing at 80 degrees C for 7 min of nisin-containing pellets were 15.5 +/- 0.9, 9.8 +/- 0.2, and 8.6 +/- 1.0 mm, respectively. Since heat-pressing for 7 min at 80 degrees C of nisin-incorporated pellets did not further inactivate nisin, this indicates that nisin inactivation during extrusion-blowing was limited. Moreover, the lower diameter of the K. rhizophila growth inhibition zone around films prepared with nisin-containing pellets compared to that observed around films directly prepared by solution casting confirms that nisin inactivation mainly occurred during the compounding step. Natamycin-containing thermoplastic films inhibited Aspergillus niger growth; however, by contrast with nisin-containing films, heat-pressed films had higher inhibition zone diameters than blown films, therefore suggesting a partial inactivation of natamycin during extrusion-blowing

Active biodegradable sodium caseinate films manufactured by blown-film extrusion: Effect of thermo-mechanical processing parameters and formulation on lysozyme stability

International audienceSodium caseinate-based edible/biodegradable films containing lysozyme were prepared directly by extrusion processes to obtain antimicrobial films. Thermoplastic pellets containing I% (w/w) lysozyme were blown by an industrial-like blown-film-extruder to obtain thermoplastic thin films. Lysozyme stability depended mainly on processing temperature and glycerol content. A correct choice of these parameters allowed obtaining pellets and films with 40.8 +/- 0.5% and 26.4 +/- 0.6% lysozyme residual activity, respectively. Whatever the storage temperature (-20 degrees C or room temperature), lysozyme activity of pellets remained constant for at least 5 weeks of storage. Antimicrobial activity against Micrococcus luteus was assayed in Tryptone Soya Broth (TSB): no bacterial growth was observed for 25 h at 37 degrees C in the presence of 0.05 g.L-1 pellets, while a 2.4 log increase of bacterial population was observed in the presence of control pellets without lysozyme. Traditional properties of films such as their water sorption and mechanical properties were also investigated and proved that addition of lysozyme at a 1% concentration did not affect these properties as well as their ultimate aerobic biodegradability. The application potential of such edible antimicrobial films is discussed in relation with these properties

Using Anthocyanin Extracts from Butterfly Pea as pH Indicator for Intelligent Gelatin Film and Methylcellulose Film

International audienceAmong variety of intelligent food packaging, pH indicator packaging is becoming more popular, which can be made from synthetic and natural compounds. The search for natural pH indicator dyes that can be used in intelligent food packaging systems has recently focused on anthocyanins extracted from plants. Thus, this work aimed to develop and characterize an intelligent tag for pH indicator based on gelatin and methylcellulose-film with butterfly pea extract (BPE). The results showed that the colors of BPE solutions had a tendency to change from red to blue in a pH range of 4.0 to 8.0. The maximum absorption peak moved to a higher wavelength was observed at around 627 nm at pH 8.0 and shifted to 574 nm when the pH decreased to 5.0. After BPE was incorporated into the gelatin and methylcellulose-based films, the film’s properties were characterized. The color of the incorporated films changed from purple to blue and blue to green in buffers with pH ranging from 2.0 to 6.0 and 7.0 to 10.0, respectively. The incorporated gelatin-based film containing BPE showed a clearer response to pH variation and showed a high pigment releasing rate when immerse in buffer of pH 10. The incorporated methylcellulose-based film containing BPE had higher water solubility than that of gelatin-based film (p < 0.05), as well as improved mechanical properties and water vapor permeability (WVP). Therefore, it is possible to use the BPE (anthocyanins) as a visual pH indicator for food package