Closed-loop separation control over a sharp edge ramp using Genetic Programming

We experimentally perform open and closed-loop control of a separating turbulent boundary layer downstream from a sharp edge ramp. The turbulent boundary layer just above the separation point has a Reynolds number $Re_{\theta}\approx 3\,500$ based on momentum thickness. The goal of the control is to mitigate separation and early re-attachment. The forcing employs a spanwise array of active vortex generators. The flow state is monitored with skin-friction sensors downstream of the actuators. The feedback control law is obtained using model-free genetic programming control (GPC) (Gautier et al. 2015). The resulting flow is assessed using the momentum coefficient, pressure distribution and skin friction over the ramp and stereo PIV. The PIV yields vector field statistics, e.g. shear layer growth, the backflow area and vortex region. GPC is benchmarked against the best periodic forcing. While open-loop control achieves separation reduction by locking-on the shedding mode, GPC gives rise to similar benefits by accelerating the shear layer growth. Moreover, GPC uses less actuation energy.Comment: 24 pages, 24 figures, submitted to Experiments in Fluid

Disruption of Dnmt1/PCNA/UHRF1 Interactions Promotes Tumorigenesis from Human and Mice Glial Cells

Global DNA hypomethylation is a hallmark of cancer cells, but its molecular mechanisms have not been elucidated. Here, we show that the disruption of Dnmt1/PCNA/UHRF1 interactions promotes a global DNA hypomethylation in human gliomas. We then demonstrate that the Dnmt1 phosphorylations by Akt and/or PKC abrogate the interactions of Dnmt1 with PCNA and UHRF1 in cellular and acelluar studies including mass spectrometric analyses and the use of primary cultured patient-derived glioma. By using methylated DNA immunoprecipitation, methylation and CGH arrays, we show that global DNA hypomethylation is associated with genes hypomethylation, hypomethylation of DNA repeat element and chromosomal instability. Our results reveal that the disruption of Dnmt1/PCNA/UHRF1 interactions acts as an oncogenic event and that one of its signatures (i.e. the low level of mMTase activity) is a molecular biomarker associated with a poor prognosis in GBM patients. We identify the genetic and epigenetic alterations which collectively promote the acquisition of tumor/glioma traits by human astrocytes and glial progenitor cells as that promoting high proliferation and apoptosis evasion

Richard (R.) : « Le financement des armements maritimes du Havre au XVIIIe siècle. Position du problème »

Debien G. Richard (R.) : « Le financement des armements maritimes du Havre au XVIIIe siècle. Position du problème ». In: Revue française d'histoire d'outre-mer, tome 57, n°208, 3e trimestre 1970. p. 376

Thésée (Françoise) : « Sur deux sucreries de Jacquesy (Nord de Saint-Domingue, 1718-1802 ». — Actes du 92e congrès national des Sociétés savantes, Strasbourg et Colmar, 1967. Section d'histoire moderne et contemporaine, t. II

Debien G. Thésée (Françoise) : « Sur deux sucreries de Jacquesy (Nord de Saint-Domingue, 1718-1802 ». — Actes du 92e congrès national des Sociétés savantes, Strasbourg et Colmar, 1967. Section d'histoire moderne et contemporaine, t. II. In: Revue française d'histoire d'outre-mer, tome 58, n°212, 3e trimestre 1971. p. 378

Fabre (Le P. Camille) : Dans le sillage des caravelles. Annales de l'Église en 1675-1970

Debien G. Fabre (Le P. Camille) : Dans le sillage des caravelles. Annales de l'Église en 1675-1970. In: Revue française d'histoire d'outre-mer, tome 64, n°234, 1er trimestre 1977. pp. 123-124

Recueil de documents et travaux inédits pour servir à l'histoire de la Réunion

Debien G. Recueil de documents et travaux inédits pour servir à l'histoire de la Réunion. In: Annales. Economies, sociétés, civilisations. 11ᵉ année, N. 4, 1956. pp. 547-548