Is real GDP per capita a stationary process? Smooth transitions, nonlinear trends and unit root testing

The aim of this paper is to provide additional evidence about the order of integration of constant price GDP per capita in a selection of countries. It does so by taking into account the possibility of non-linear deterministic trends and of asymmetric adjustment towards equilibrium. We find evidence of a global stationary ESTAR process around a nonlinear deterministic trend in almost half of the selected countries. These results show that nonlinearities affect real GDP series. By neglecting them, one can draw misleading conclusions from unit root tests. Specifically, the paper questions the so-called stylised fact of a near unit root which has so influenced macroeconomic thought over the past two decades.Real GDP per capita, Unit root tests, Persistence, Nonlinearities, Smooth transitions

Developing navigational services for people with Down's Syndrome

The ability to commute and travel alone is an important skill that enables people to be more independent, and integrated with society. People with Down's Syndrome often experience low social integration, and low degree of independence. As part of the European Commission funded POSEIDON project, we want to explore how context-aware, and assistive technology can enable users with Down's Syndrome be more independent, including the ability to commute alone to a place of interest. In this paper, we report on our current progress in developing navigational services within the context of the POSEIDON project. We carried out a semi-structured qualitative evaluation of an early version of our navigational services with 6 individuals with Down's Syndrome, and report on our findings

Initiating informatics and GIS support for a field investigation of Bioterrorism: The New Jersey anthrax experience

BACKGROUND: The investigation of potential exposure to anthrax spores in a Trenton, New Jersey, mail-processing facility required rapid assessment of informatics needs and adaptation of existing informatics tools to new physical and information-processing environments. Because the affected building and its computers were closed down, data to list potentially exposed persons and map building floor plans were unavailable from the primary source. RESULTS: Controlling the effects of anthrax contamination required identification and follow-up of potentially exposed persons. Risk of exposure had to be estimated from the geographic relationship between work history and environmental sample sites within the contaminated facility. To assist in establishing geographic relationships, floor plan maps of the postal facility were constructed in ArcView Geographic Information System (GIS) software and linked to a database of personnel and visitors using Epi Info and Epi Map 2000. A repository for maintaining the latest versions of various documents was set up using Web page hyperlinks. CONCLUSIONS: During public health emergencies, such as bioterrorist attacks and disease epidemics, computerized information systems for data management, analysis, and communication may be needed within hours of beginning the investigation. Available sources of data and output requirements of the system may be changed frequently during the course of the investigation. Integrating data from a variety of sources may require entering or importing data from a variety of digital and paper formats. Spatial representation of data is particularly valuable for assessing environmental exposure. Written documents, guidelines, and memos important to the epidemic were frequently revised. In this investigation, a database was operational on the second day and the GIS component during the second week of the investigation

The user-centred intelligent environments development process as a guide to co-create smart technology for people with special needs

We report on the lessons learnt during the application of a methodology to develop Intelligent Environments. One important feature of the methodology is that of being strongly user-centred and we report on how that interaction with users took place and how it continuously shaped our project aspirations and outcomes. The methodology was applied to a project which aimed at helping people with Downs Syndrome and those with similar conditions and needs, to be more included in society. The project was developed by amconsortium of commercial, academic, and end-user supporting organizations. We explain what type of stakeholders engaging activities were considered, how these were distributed along the lifetime of the project and their impact

Assessing real world imagery in virtual environments for people with cognitive disabilities

People with cognitive disabilities are often socially excluded. We propose a system based on Virtual and Augmented Reality that has the potential to act as an educational and support tool in everyday tasks for people with cognitive disabilities. Our solution consists of two components: the first that enables users to train for several essential quotidian activities and the second that is meant to offer real time guidance feedback for immediate support. In order to illustrate the functionality of our proposed system, we chose to train and support navigation skills. Thus, we conducted a preliminary study on people with Down Syndrome (DS) based on a navigation task. Our experiment was aimed at evaluating the visual and spatial perception of people with DS when interacting with different elements of our system. We provide a preliminary evaluation that illustrates how people with DS perceive different landmarks and types of visual feedback, in static images and videos. Although we focused our study on people with DS, people with different cognitive disabilities could also benefit from the features of our solution. This analysis is mandatory in the design of a virtual intelligent system with several functionalities that aims at helping disabled people in developing basic knowledge in every day tasks

Co-creation of smart technology with (and for) people with special needs

We report on the lessons learnt during the application of a methodology to develop Intelligent Environments. This methodology was applied to a project which aimed at helping people with Down’s Syndrome and those with similar conditions and needs, to be more included in society. The project is developed by a consortium of commercial, academic, and enduser supporting organizations. One important feature of the methodology is that of being strongly user-centred and we report on how that interaction with users took place and how it continuously shaped the projec

A survey on the evolution of the notion of context-awareness

The notion of Context has been considered for a long time in different areas of Computer Science. This article considers the use of context-based reasoning from the earlier perspective of AI as well as the newer developments in Ubiquitous Computing. Both communities have been somehow interested in the potential of context-reasoning to support real-time meaningful reactions from systems. We explain how the concept evolved in each of these different approaches. We found initially each of them considered this topic quite independently and separated from each other, however latest developments have started to show signs of cross-fertilization amongst these areas. The aim of our survey is to provide an understanding on the way context and context-reasoning were approached, to show that work in each area is complementary, and to highlight there are positive synergies arising amongst them. The overarching goal of this article is to encourage further and longer-term synergies between those interested in further understanding and using context-based reasoning

Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage.

Somatic mutations in the endoplasmic reticulum chaperone calreticulin (CALR) are detected in approximately 40% of patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF). Multiple different mutations have been reported, but all result in a +1-bp frameshift and generate a novel protein C terminus. In this study, we generated a conditional mouse knockin model of the most common CALR mutation, a 52-bp deletion. The mutant novel human C-terminal sequence is integrated into the otherwise intact mouse CALR gene and results in mutant CALR expression under the control of the endogenous mouse locus. CALRdel/+ mice develop a transplantable ET-like disease with marked thrombocytosis, which is associated with increased and morphologically abnormal megakaryocytes and increased numbers of phenotypically defined hematopoietic stem cells (HSCs). Homozygous CALRdel/del mice developed extreme thrombocytosis accompanied by features of MF, including leukocytosis, reduced hematocrit, splenomegaly, and increased bone marrow reticulin. CALRdel/+ HSCs were more proliferative in vitro, but neither CALRdel/+ nor CALRdel/del displayed a competitive transplantation advantage in primary or secondary recipient mice. These results demonstrate the consequences of heterozygous and homozygous CALR mutations and provide a powerful model for dissecting the pathogenesis of CALR-mutant ET and PMF