60 research outputs found

    Tissue distribution of the laminin β1 and β2 chain during embryonic and fetal human development

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    Laminins are the major glycoproteins present in all basement membranes. Previously, we showed that perlecan is present during human development. Although an overview of mRNA-expression of the laminin β1 and β2 chains in various developing fetal organs is already available, a systematic localization of the laminin β1 and β2 chains on the protein level during embryonic and fetal human development is missing. Therefore, we studied the immunohistochemical expression and tissue distribution of the laminin β1 and β2 chains in various developing embryonic and fetal human organs between gestational weeks 8 and 12. The laminin β1 chain was ubiquitously expressed in the basement membrane zones of the brain, ganglia, blood vessels, liver, kidney, skin, pancreas, intestine, heart and skeletal system. Furthermore, the laminin β2 chain was present in the basement membrane zones of the brain, ganglia, skin, heart and skeletal system. The findings of this study support and expand upon the theory that these two laminin chains are important during human development

    Resonant photoemission studies of the magnetic-nonmagnetic U(Sn,In)3U(Sn,In)_3 system

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    Results of 5d-5f resonant photoemission studies on the related series of uranium intermetallic compounds, U(Sn_xIn_{1-x})_3} for x=1.0, 0.5 and 0.0 are presented. Various features seen in the spectra are analyzed in terms of calculated partial densities of states. With the help of difference spectra between on and off resonance spectra obtained at photon energies of 98 and 92 eV, respectively, it is shown that spectral shapes of the U 5f related features do not exhibit any significant change within the series, even though the electronic and magnetic properties of these compounds are drastically different. A brief discussion of the implications of these observations is also presente
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