36 research outputs found

    Cardiovascular and renal outcomes with empagliflozin in heart failure

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    BACKGROUND Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of hospitalization for heart failure in patients regardless of the presence or absence of diabetes. More evidence is needed regarding the effects of these drugs in patients across the broad spectrum of heart failure, including those with a markedly reduced ejection fraction. METHODS In this double-blind trial, we randomly assigned 3730 patients with class II, III, or IV heart failure and an ejection fraction of 40% or less to receive empagliflozin (10 mg once daily) or placebo, in addition to recommended therapy. The primary outcome was a composite of cardiovascular death or hospitalization for worsening heart failure. RESULTS During a median of 16 months, a primary outcome event occurred in 361 of 1863 patients (19.4%) in the empagliflozin group and in 462 of 1867 patients (24.7%) in the placebo group (hazard ratio for cardiovascular death or hospitalization for heart failure, 0.75; 95% confidence interval [CI], 0.65 to 0.86; P<0.001). The effect of empagliflozin on the primary outcome was consistent in patients regardless of the presence or absence of diabetes. The total number of hospitalizations for heart failure was lower in the empagliflozin group than in the placebo group (hazard ratio, 0.70; 95% CI, 0.58 to 0.85; P<0.001). The annual rate of decline in the estimated glomerular filtration rate was slower in the empagliflozin group than in the placebo group (-0.55 vs. -2.28 ml per minute per 1.73 m2 of body-surface area per year, P<0.001), and empagliflozin-treated patients had a lower risk of serious renal outcomes. Uncomplicated genital tract infection was reported more frequently with empagliflozin. CONCLUSIONS Among patients receiving recommended therapy for heart failure, those in the empagliflozin group had a lower risk of cardiovascular death or hospitalization for heart failure than those in the placebo group, regardless of the presence or absence of diabetes

    Search for the Zγ decay mode of new high-mass resonances in pp collisions at s = 13 TeV with the ATLAS detector

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    This letter presents a search for narrow, high-mass resonances in the Zγ final state with the Z boson decaying into a pair of electrons or muons. The TeV pp collision data were recorded by the ATLAS detector at the CERN Large Hadron Collider and have an integrated luminosity of 140 fb−1. The data are found to be in agreement with the Standard Model background expectation. Upper limits are set on the resonance production cross section times the decay branching ratio into Zγ. For spin-0 resonances produced via gluon–gluon fusion, the observed limits at 95% confidence level vary between 65.5 fb and 0.6 fb, while for spin-2 resonances produced via gluon–gluon fusion (or quark–antiquark initial states) limits vary between 77.4 (76.1) fb and 0.6 (0.5) fb, for the mass range from 220 GeV to 3400 GeV

    Luminosity determination in pp collisions at √s=13TeV using the ATLAS detector at the LHC

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    Pursuit of paired dijet resonances in the Run 2 dataset with ATLAS

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    New particles with large masses that decay into hadronically interacting particles are predicted by many models of physics beyond the Standard Model. A search for a massive resonance that decays into pairs of dijet resonances is performed using..

    Measurement of the HγγH \rightarrow \gamma \gamma and HZZ4H \rightarrow ZZ^* \rightarrow 4 \ell cross-sections in pp collisions at s=13.6\sqrt{s}=13.6 TeV with the ATLAS detector

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    Performance of the reconstruction of large impact parameter tracks in the inner detector of ATLAS

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    Search for exclusive Higgs and Z boson decays to ωγ and Higgs boson decays to K ⁎ γ with the ATLAS detector

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    Searches for the exclusive decays of the Higgs boson to an ω meson and a photon or a K⁎ meson and a photon can probe flavour-conserving and flavour-violating Higgs boson couplings to light quarks, respectively. Searches for these decays, along with the analogous Z boson decay to an ω meson and a photon, are performed with a pp collision data sample corresponding to integrated luminosities of up to 134 fb−1 collected at √s=13 TeV with the ATLAS detector at the CERN Large Hadron Collider. The obtained 95% confidence-level upper limits on the respective branching fractions are B(H→ωγ)<5.5×10−4, B(H→K⁎γ)<2.2×10−4 and B(Z→ωγ)<3.9×10−6. The limits for H→ωγ and Z→ωγ are 370 times and 140 times the Standard Model expected values, respectively. The result for Z→ωγ corresponds to a two-orders-of-magnitude improvement over the limit obtained by the DELPHI experiment at LEP
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