38 research outputs found

    Polymorphism: an evaluation of the potential risk to the quality of drug products from the Farmácia Popular Rede Própria

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    Polymorphism in solids is a common phenomenon in drugs, which can lead to compromised quality due to changes in their physicochemical properties, particularly solubility, and, therefore, reduce bioavailability. Herein, a bibliographic survey was performed based on key issues and studies related to polymorphism in active pharmaceutical ingredient (APIs) present in medications from the Farmácia Popular Rede Própria. Polymorphism must be controlled to prevent possible ineffective therapy and/or improper dosage. Few mandatory tests for the identification and control of polymorphism in medications are currently available, which can result in serious public health concerns

    Low‐slow‐small target detection using stepped‐frequency signals in a strong folded clutter environment

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    Frequency‐modulated magneto‐acoustic detection and imaging

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