RCW 49 at mid-infrared wavelengths: A glimpse from the Spitzer Space Telescope

The luminous, massive star formation region RCW 49, located in the southern Galactic plane, was imaged with the Infrared Array Camera (IRAC) on the Spitzer Space Telescope as part of the Galactic Legacy Infrared Mid-Plane Survey Extraordinaire (GLIMPSE) program. The IRAC bands contain polycyclic aromatic hydrocarbon (PAH) features at 3.3, 6.2, 7.7, and 8.6 μm, as well as the Brα line. These features are the major contributors to the diffuse emission from RCW 49 in the IRAC bands. The Spitzer IRAC images show that the dust in RCW 49 is distributed in a network of fine filaments, pillars, knots, sharply defined boundaries, bubbles, and bow shocks. The regions immediately surrounding the ionizing star cluster and W-R stars are evacuated of dust by stellar winds and radiation. The IRAC images of RCW 49 suggest that the dust in RCW 49 has been sculpted by the winds and radiation from the embedded luminous stars in the inner 5′ (inner ∼6 pc) of the nebula. At projected angular radii φ > 5′ from the central ionizing cluster, the azimuthally averaged infrared intensity falls off as ∼φ-3. Both high-resolution radio and mid-IR images suggest that the nebula is density bounded along its western boundary. The filamentary structure of the dust in RCW 49 suggests that the nebula has a small dust filling factor and, as a consequence, the entire nebula may be slightly density bounded to H-ionizing photons

Identification of main-sequence stars with mid-infrared excesses using glimpse: β pictoris analogs?

Spitzer IRAC 3.6-8 μm photometry obtained as part of the GLIMPSE survey has revealed mid-infrared excesses for 33 field stars with known spectral types in a 1.2 deg2 field centered on the southern Galactic H II region RCW 49. These stars comprise a subset of 184 stars with known spectral classification, most of which were preselected to have unusually red IR colors. We propose that the mid-IR excesses are caused by circumstellar dust disks that are either very late remnants of stellar formation or debris disks generated by planet formation. Of these 33 stars, 29 appear to be main-sequence stars on the basis of optical spectral classifications. Five of the 29 main-sequence stars are O or B stars with excesses that can be plausibly explained by thermal bremsstrahlung emission, and four are post-main-sequence stars. The lone O star is an O4 V((f)) at a spectrophotometric distance of 3233-535 +540 pc and may be the earliest member of the Westerlund 2 cluster. Of the remaining 24 main-sequence stars, 18 have spectral energy distributions that are consistent with hot dusty debris disks, a possible signature of planet formation. Modeling the excesses as blackbodies demonstrates that the blackbody components have fractional bolometric disk-to-star luminosity ratios, L IR/L*, ranging from 10-3 to 10-2 with temperatures ranging from 220 to 820 K. The inferred temperatures are more consistent with asteroid belts than with the cooler temperatures expected for Kuiper belts. Mid-IR excesses are found in all spectral types from late B to early K

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

Renal cell carcinoma(RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers. Somatic alteration of BAP1, PBRM1, and PTEN and altered metabolic pathways correlated with subtype-specific decreased survival, while CDKN2A alteration, increased DNA hypermethylation, and increases in the immune-related Th2 gene expression signature correlated with decreased survival within all major histologic subtypes. CIMP-RCC demonstrated an increased immune signature, and a uniform and distinct metabolic expression pattern identified a subset of metabolically divergent (MD) ChRCC that associated with extremely poor survival

Responses of the HPA axis after chronic variable stress: Effects of novel and familiar stressors

OBJECTIVES: We examined the role that novelty plays in determining interactions between chronic and acute stress, when both the chronic and acute stressors emphasize emotional processing (i.e. stressful stimuli that do not present immediate threats to somatic homeostasis, and are processed primarily by limbic and forebrain circuits). METHODS: Rats were exposed to a chronic variable stress (CVS) regimen, and were subsequently tested to evaluate responses to novel and familiar acute stressors. One group was exposed to CVS that included restraint, and was then tested with this familiar stressor. Another group was exposed to CVS that did not include restraint, and were tested with restraint as a novel stressor. Additional rats were not chronically stressed. Plasma adrenocorticotrophic hormone (ACTH) and corticosterone (CORT) were assayed. RESULTS: When the rats were exposed to familiar acute stress after CVS, ACTH responses were blunted. The ACTH responses were normal in the rats that were tested with novel acute stress--the responses resembled those of rats that had no prior stress experience. CORT responses did not differ between the groups, regardless of stress history. CONCLUSIONS: Despite the fact that all the chronic and acute stressors emphasized emotional processing of aversive stimuli, and thus likely involved overlapping limbic and forebrain circuits, the hormonal responses differed depending upon familiarity with the acute stressor. Further research is required to identify the neuronal mechanisms that mediate these differing responses to novel and familiar emotional stressors

Glutamate-mediated neuroplasticity in a limbic input to the hypothalamus

Emotionally-salient stressors are processed by cortical and limbic circuits that provide important regulatory input to the hypothalamic-pituitary-adrenal (HPA) axis. However, exposure to chronic or severe stress may cause disregulation of the axis and a variety of physiological and psychological symptoms. The mechanisms that underlie stress-induced alterations in HPA axis function are not well characterized, but one possibility is that severe stress causes plastic changes in limbic inputs to the hypothalamus. We examined plasticity within the bed nucleus of stria terminalis (BNST) and the hypothalamic paraventricular nucleus (PVN) with a stimulating electrode in the BNST and a recording electrode in the PVN. High-frequency BNST stimulation produced long-lasting suppression of evoked field potentials recorded from the PVN, and this effect was blocked by administration of MK-801. Accordingly, rapid glutamate-mediated neuroplasticity in the BNST to PVN neurocircuitry may contribute to plasticity in limbic regulation of the HPA axis