9 research outputs found
Microscopic View on Short-Range Wetting at the Free Surface of the Binary Metallic Liquid Gallium-Bismuth: An X-ray Reflectivity and Square Gradient Theory Study
We present an x-ray reflectivity study of wetting at the free surface of the
binary liquid metal gallium-bismuth (Ga-Bi) in the region where the bulk phase
separates into Bi-rich and Ga-rich liquid phases. The measurements reveal the
evolution of the microscopic structure of wetting films of the Bi-rich,
low-surface-tension phase along different paths in the bulk phase diagram. A
balance between the surface potential preferring the Bi-rich phase and the
gravitational potential which favors the Ga-rich phase at the surface pins the
interface of the two demixed liquid metallic phases close to the free surface.
This enables us to resolve it on an Angstrom level and to apply a mean-field,
square gradient model extended by thermally activated capillary waves as
dominant thermal fluctuations. The sole free parameter of the gradient model,
i.e. the so-called influence parameter, , is determined from our
measurements. Relying on a calculation of the liquid/liquid interfacial tension
that makes it possible to distinguish between intrinsic and capillary wave
contributions to the interfacial structure we estimate that fluctuations affect
the observed short-range, complete wetting phenomena only marginally. A
critical wetting transition that should be sensitive to thermal fluctuations
seems to be absent in this binary metallic alloy.Comment: RevTex4, twocolumn, 15 pages, 10 figure
Zinc deficiency-induced changes in the composition of microsomal membranes and in the enzymatic regulation of glycerolipid synthesis
T-cell nature of leukaemic cells in a case of Sezary's syndrome with 'null-cell' features.
Visualization of the Specific Gene Transcription in the Nucleus with a Novel In Situ RNase Protection Method.
Restorative Justice Programs, Gender, and Recidivism
Restorative justice programs, which attempt to reintegrate offenders into society by building and strengthening interpersonal relationships, may provide the juvenile justice system with an effective option for female offenders. If women and men have different values, and women value connections with others while men value independence and autonomy [Gilligan, C. (1982). In A Different Voice. Cambridge, Massachusetts: Harvard University Press], then programs that explicitly focus on strengthening social bonds may be compatible with the value orientation of women. However, research on the operation of the juvenile justice system has noted a history of gender bias, as traditional notions of gender roles were reinforced by juvenile justice system professionals. While restorative justice programs may be effective in reducing recidivism among female offenders, at the same time, the informal nature of these programs may lead to the reinforcement of traditional gender roles. Copyright Springer Science + Business Media, Inc. 2005restorative justice, gender bias, recidivism,
ARF1·GTP, Tyrosine-based Signals, and Phosphatidylinositol 4,5-Bisphosphate Constitute a Minimal Machinery to Recruit the AP-1 Clathrin Adaptor to Membranes
At the trans-Golgi network, clathrin coats containing AP-1 adaptor complexes are formed in an ARF1-dependent manner, generating vesicles transporting cargo proteins to endosomes. The mechanism of site-specific targeting of AP-1 and the role of cargo are poorly understood. We have developed an in vitro assay to study the recruitment of purified AP-1 adaptors to chemically defined liposomes presenting peptides corresponding to tyrosine-based sorting motifs. AP-1 recruitment was found to be dependent on myristoylated ARF1, GTP or nonhydrolyzable GTP-analogs, tyrosine signals, and small amounts of phosphoinositides, most prominently phosphatidylinositol 4,5-bisphosphate, in the absence of any additional cytosolic or membrane bound proteins. AP-1 from cytosol could be recruited to a tyrosine signal independently of the lipid composition, but the rate of recruitment was increased by phosphatidylinositol 4,5-bisphosphate. The results thus indicate that cargo proteins are involved in coat recruitment and that the local lipid composition contributes to specifying the site of vesicle formation