31 research outputs found

    MicroRNA Expression in Alzheimer Blood Mononuclear Cells

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    Timeline Localization

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    International audienceThe research findings provide evidence that time-oriented data visualizations can contribute to faster information processing, bet-ter understanding and improved recall. Thus, they are used in many application domains – medicine, law enforcement, traffic and navigation control to name but a few. Simultaneously, human's time perception varies depending inter alia on culture, language, personal experience and situational factors. Although, the differences caused by the aforemen-tioned aspects were acknowledged and addressed in the Human Com-puter Interaction (HCI) field for decades their impact on time-oriented data visualizations was largely neglected. To fill this gap, we investigate the influence of time spatializations (or-ganization of time along axes) on the response time and accuracy of inferences based on time-oriented data visualizations. Moreover, we ex-amine users' preferences toward different time arrangements. Our find-ings show that user-adapted organization of time along axes can speed up the decision-making process and increase the user experience

    New measurement of double beta decays of 100^{100}Mo to excited states of 100^{100}Ru with the CUPID-Mo experiment

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    The CUPID-Mo experiment, located at Laboratoire Souterrain de Modane (France), was a demonstrator experiment for CUPID. It consisted of an array of 20 Li2100_2^{100}MoO4_4 (LMO) calorimeters each equipped with a Ge light detector (LD) for particle identification. In this work, we present the result of a search for two-neutrino and neutrinoless double beta decays of 100^{100}Mo to the first 0+^+ and 2+2^+ excited states of 100^{100}Ru using the full CUPID-Mo exposure (2.71 kg×\timesyr of LMO). We measure the half-life of 2νββ2\nu\beta\beta decay to the 01+0^{+}_1 state as T1/22ν01+=7.5±0.8 (stat.) 0.3+0.4 (syst.))×1020 yrT_{1/2}^{2\nu \rightarrow 0_1^+}=7.5\pm 0.8 \ \text{(stat.)} \ ^{+ 0.4}_{-0.3} \ \text{(syst.)} )\times 10^{20} \ \mathrm{yr}. The bolometric technique enables measurement of the electron energies as well as the gamma rays from nuclear de-excitation and this allows us to set new limits on the two-neutrino decay to the 21+2_1^+ state of T^{2\nu \rightarrow 2_1^+}_{1/2}>4.4\times 10^{21} \ \mathrm{yr} \ \text{(90 % c.i.)} and on the neutrinoless modes of T_{1/2}^{0\nu\rightarrow 2_1^+}>2.1\times10^{23} \ \mathrm{yr}\ \text{(90 % c.i.)}, T_{1/2}^{0\nu\rightarrow 0_1^+}>1.2\times10^{23} \ \mathrm{yr}\ \text{(90 % c.i.)}. Information on the electrons spectral shape is obtained which allows us to make the first comparison of the single state (SSD) and higher state (HSD) 2νββ2\nu\beta\beta decay models for the 01+0_1^+ excited state of 100^{100}Ru

    Final results on the 0νββ0\nu\beta\beta decay half-life limit of 100^{100}Mo from the CUPID-Mo experiment

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    The CUPID-Mo experiment to search for 0νββ\nu\beta\beta decay in 100^{100}Mo has been recently completed after about 1.5 years of operation at Laboratoire Souterrain de Modane (France). It served as a demonstrator for CUPID, a next generation 0νββ\nu\beta\beta decay experiment. CUPID-Mo was comprised of 20 enriched Li2_2100^{100}MoO4_4 scintillating calorimeters, each with a mass of \sim 0.2 kg, operated at \sim20 mK. We present here the final analysis with the full exposure of CUPID-Mo (100^{100}Mo exposure of 1.47 kg×\timesyr) used to search for lepton number violation via 0νββ\nu\beta\beta decay. We report on various analysis improvements since the previous result on a subset of data, reprocessing all data with these new techniques. We observe zero events in the region of interest and set a new limit on the 100^{100}Mo 0νββ\nu\beta\beta decay half-life of T1/20ν>1.8×1024T^{0\nu}_{1/2} > 1.8 \times 10^{24} year (stat.+syst.) at 90% C.I. Under the light Majorana neutrino exchange mechanism this corresponds to an effective Majorana neutrino mass of \left < (0.28--0.49)0.49) eV, dependent upon the nuclear matrix element utilized

    The background model of the CUPID-Mo 0νββ0\nu\beta\beta experiment

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    International audienceCUPID-Mo, located in the Laboratoire Souterrain de Modane (France), was a demonstrator for the next generation 0νββ0\nu\beta\beta decay experiment, CUPID. It consisted of an array of 20 enriched Li2_{2}100 ^{100}MoO4_4 bolometers and 20 Ge light detectors and has demonstrated that the technology of scintillating bolometers with particle identification capabilities is mature. Furthermore, CUPID-Mo can inform and validate the background prediction for CUPID. In this paper, we present a detailed model of the CUPID-Mo backgrounds. This model is able to describe well the features of the experimental data and enables studies of the 2νββ2\nu\beta\beta decay and other processes with high precision. We also measure the radio-purity of the Li2_{2}100^{100}MoO4_4 crystals which are found to be sufficient for the CUPID goals. Finally, we also obtain a background index in the region of interest of 3.70.8+0.9^{+0.9}_{-0.8}(stat)0.7+1.5^{+1.5}_{-0.7}(syst)×103\times10^{-3}counts/Δ\DeltaEFWHM_{FWHM}/moliso_{iso}/yr, the lowest in a bolometric 0νββ0\nu\beta\beta decay experiment

    Final results on the 0νββ0\nu\beta\beta decay half-life limit of 100^{100}Mo from the CUPID-Mo experiment

    No full text
    The CUPID-Mo experiment to search for 0νββ\nu\beta\beta decay in 100^{100}Mo has been recently completed after about 1.5 years of operation at Laboratoire Souterrain de Modane (France). It served as a demonstrator for CUPID, a next generation 0νββ\nu\beta\beta decay experiment. CUPID-Mo was comprised of 20 enriched Li2_2100^{100}MoO4_4 scintillating calorimeters, each with a mass of \sim 0.2 kg, operated at \sim20 mK. We present here the final analysis with the full exposure of CUPID-Mo (100^{100}Mo exposure of 1.47 kg×\timesyr) used to search for lepton number violation via 0νββ\nu\beta\beta decay. We report on various analysis improvements since the previous result on a subset of data, reprocessing all data with these new techniques. We observe zero events in the region of interest and set a new limit on the 100^{100}Mo 0νββ\nu\beta\beta decay half-life of T1/20ν>1.8×1024T^{0\nu}_{1/2} > 1.8 \times 10^{24} year (stat.+syst.) at 90% C.I. Under the light Majorana neutrino exchange mechanism this corresponds to an effective Majorana neutrino mass of \left < (0.28--0.49)0.49) eV, dependent upon the nuclear matrix element utilized

    New measurement of double beta decays of 100^{100}Mo to excited states of 100^{100}Ru with the CUPID-Mo experiment

    No full text
    The CUPID-Mo experiment, located at Laboratoire Souterrain de Modane (France), was a demonstrator experiment for CUPID. It consisted of an array of 20 Li2100_2^{100}MoO4_4 (LMO) calorimeters each equipped with a Ge light detector (LD) for particle identification. In this work, we present the result of a search for two-neutrino and neutrinoless double beta decays of 100^{100}Mo to the first 0+^+ and 2+2^+ excited states of 100^{100}Ru using the full CUPID-Mo exposure (2.71 kg×\timesyr of LMO). We measure the half-life of 2νββ2\nu\beta\beta decay to the 01+0^{+}_1 state as T1/22ν01+=7.5±0.8 (stat.) 0.3+0.4 (syst.))×1020 yrT_{1/2}^{2\nu \rightarrow 0_1^+}=7.5\pm 0.8 \ \text{(stat.)} \ ^{+ 0.4}_{-0.3} \ \text{(syst.)} )\times 10^{20} \ \mathrm{yr}. The bolometric technique enables measurement of the electron energies as well as the gamma rays from nuclear de-excitation and this allows us to set new limits on the two-neutrino decay to the 21+2_1^+ state of T^{2\nu \rightarrow 2_1^+}_{1/2}>4.4\times 10^{21} \ \mathrm{yr} \ \text{(90 % c.i.)} and on the neutrinoless modes of T_{1/2}^{0\nu\rightarrow 2_1^+}>2.1\times10^{23} \ \mathrm{yr}\ \text{(90 % c.i.)}, T_{1/2}^{0\nu\rightarrow 0_1^+}>1.2\times10^{23} \ \mathrm{yr}\ \text{(90 % c.i.)}. Information on the electrons spectral shape is obtained which allows us to make the first comparison of the single state (SSD) and higher state (HSD) 2νββ2\nu\beta\beta decay models for the 01+0_1^+ excited state of 100^{100}Ru
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