Inversion of Plasmaspheric EUV Remote Sensing Data from the STP 72-1 Satellite

Observations of the extreme ultraviolet emission of helium ions at 30.4 nm can be used to study the global shape of the plasmasphere and its dynamical response to geomagnetic forcing. In order to retrieve number densities of plasmaspheric He+ from such observations, we have developed a new inversion technique based on discrete inverse theory, which uses the optical data to optimize a parameterized model of the He+ distribution. We apply this inversion technique to several orbits of data obtained from the Naval Research Laboratory extreme ultraviolet photometric experiment launched on the STP 72-1 satellite in October 1972. The inversion is limited to nighttime conditions where contamination from the topside ionosphere is minimal and where a simple parameterization of the He+ number density is applicable. We obtain excellent fits to the data; however, some of the retrieved model parameters have large uncertainties due to inadequate sampling of the plasmasphere. Our study shows that improved sampling using observations from different locations and view directions would significantly enhance the accuracy of the retrieved model parameters. Using a newly developed three-dimensional imaging tool to visualize the plasmaspheric regions being sampled remotely, we demonstrate that emission features observed from two of the STP 72-1 orbits originate beyond the plasmasphere. Estimated number densities of this feature are roughly consistent with observations of cold plasma seen at geosynchronous orbit by in situ experiments

Antigenic Relationships among Human Pathogenic Orientia tsutsugamushi Isolates from Thailand

Scrub typhus is a common cause of undiagnosed febrile illness in certain tropical regions, but can be easily treated with antibiotics. The causative agent, Orientia tsutsugamushi, is antigenically variable which complicates diagnosis and efforts towards vaccine development. Methodology/Principal Findings: This study aimed to dissect the antigenic and genetic relatedness of O. tsutsugamushi strains and investigate sero-diagnostic reactivities by titrating individual patient sera against their O. tsutsugamushi isolates (whole-cell antigen preparation), in homologous and heterologous serum-isolate pairs from the same endemic region in NE Thailand. The indirect immunofluorescence assay was used to titrate Orientia tsutsugamushi isolates and human sera, and a mathematical technique, antigenic cartography, was applied to these data to visualise the antigenic differences and cross-reactivity between strains and sera. No functional or antigen-specific analyses were performed. The antigenic variation found in clinical isolates was much less pronounced than the genetic differences found in the 56kDa type-specific antigen genes. The Karp-like sera were more broadly reactive than the Gilliam-like sera. Conclusions/Significance: Antigenic cartography worked well with scrub typhus indirect immunofluorescence titres. The data from humoral responses suggest that a Karp-like strain would provide broader antibody cross-reactivity than a Gilliam-like strain. Although previous exposure to O. tsutsugamushi could not be ruled out, scrub typhus patient serum antibody responses were characterised by strong homologous, but weak heterologous antibody titres, with little evidence for cross-reactivity by Gilliam-like sera, but a broader response from some Karp-like sera. This work highlights the importance of antigenic variation in O. tsutsugamushi diagnosis and determination of new serotypes

Antigenic Relationships among Human Pathogenic Orientia tsutsugamushi Isolates from Thailand

Scrub typhus is a common cause of undiagnosed febrile illness in certain tropical regions, but can be easily treated with antibiotics. The causative agent, Orientia tsutsugamushi, is antigenically variable which complicates diagnosis and efforts towards vaccine development. Methodology/Principal Findings: This study aimed to dissect the antigenic and genetic relatedness of O. tsutsugamushi strains and investigate sero-diagnostic reactivities by titrating individual patient sera against their O. tsutsugamushi isolates (whole-cell antigen preparation), in homologous and heterologous serum-isolate pairs from the same endemic region in NE Thailand. The indirect immunofluorescence assay was used to titrate Orientia tsutsugamushi isolates and human sera, and a mathematical technique, antigenic cartography, was applied to these data to visualise the antigenic differences and cross-reactivity between strains and sera. No functional or antigen-specific analyses were performed. The antigenic variation found in clinical isolates was much less pronounced than the genetic differences found in the 56kDa type-specific antigen genes. The Karp-like sera were more broadly reactive than the Gilliam-like sera. Conclusions/Significance: Antigenic cartography worked well with scrub typhus indirect immunofluorescence titres. The data from humoral responses suggest that a Karp-like strain would provide broader antibody cross-reactivity than a Gilliam-like strain. Although previous exposure to O. tsutsugamushi could not be ruled out, scrub typhus patient serum antibody responses were characterised by strong homologous, but weak heterologous antibody titres, with little evidence for cross-reactivity by Gilliam-like sera, but a broader response from some Karp-like sera. This work highlights the importance of antigenic variation in O. tsutsugamushi diagnosis and determination of new serotypes

User-centric analytic approach to evaluate the performance of sports facilities: A study of swimming pools

While the performance of sports facilities such as swimming pools is crucial to the health, safety and enjoyment of pool users, little research has been conducted to explore how to analytically evaluate the holistic performance of such facilities from the users' perspective. Even an evaluation framework portraying the key performance attributes of swimming pools is yet to be available. Recognising this research gap, this study aims to adopt a user-centric approach to evaluate the performance of swimming pools and a multi-stage study was initiated. After a thorough literature review, a performance attribute hierarchy for swimming pools was established through a focus group study and then two surveys, covering four swimming pools and 103 pool users interviewed, were conducted in Hong Kong. Analysing the responses using the Analytic Hierarchy Process (AHP) method illustrates that the building services (i.e. utilitarian) aspect of swimming pools is more important than the architectural counterpart, and survey participants cared more about the performance attributes inside water than those outside. This study's novelty lies in that it adopted the user-centric approach, which can differentiate between the relative importance of different swimming pool components and prioritize resources for their maintenance and management. The evaluation framework as well as the findings of the study provides facilities managers with important benchmark criteria for optimising the performance of these sports facilities. In the long run, this study contributes to enabling the project stakeholders to conduct evidence-based decision making over the life cycle of sport facilities development and management

Quantum railroads and directed localization at the juncture of quantum Hall systems

The integer quantum Hall effect (QHE) and one-dimensional Anderson localization (AL) are limiting special cases of a more general phenomenon, directed localization (DL), predicted to occur in disordered one-dimensional wave guides called "quantum railroads" (QRR). Here we explain the surprising results of recent measurements by Kang et al. [Nature 403, 59 (2000)] of electron transfer between edges of two-dimensional electron systems and identify experimental evidence of QRR's in the general, but until now entirely theoretical, DL regime that unifies the QHE and AL. We propose direct experimental tests of our theory.Comment: 11 pages revtex + 3 jpeg figures, to appear in Phys. Rev.

Phonon-drag effects on thermoelectric power

We carry out a calculation of the phonon-drag contribution $S_g$ to the thermoelectric power of bulk semiconductors and quantum well structures for the first time using the balance equation transport theory extended to the weakly nonuniform systems. Introducing wavevector and phonon-mode dependent relaxation times due to phonon-phonon interactions, the formula obtained can be used not only at low temperatures where the phonon mean free path is determined by boundary scattering, but also at high temperatures. In the linear transport limit, $S_g$ is equivalent to the result obtained from the Boltzmann equation with a relaxation time approximation. The theory is applied to experiments and agreement is found between the theoretical predictions and experimental results. The role of hot-electron effects in $S_g$ is discussed. The importance of the contribution of $S_g$ to thermoelectric power in the hot-electron transport condition is emphasized.Comment: 8 pages, REVTEX 3.0, 7 figures avilable upon reques

Preparation and Application of an Inexpensive α‐Formylglycine Building Block Compatible with Fmoc Solid-Phase Peptide Synthesis

α-Formylglycine (fGly) is a rare residue located in the active site of sulfatases and serves as a precursor to pharmaceutically relevant motifs. The installation of fGly motifs into peptides is currently challenging due to degradation under the acidic and nucleophile-rich conditions accompanying resin cleavage during solid-phase peptide synthesis. We report the synthesis of acid- and nucleophile-tolerant α-formylglycine building blocks from vitamin C and use them to prepare callyaerin A, a macrocyclic peptide containing an fGly-derived motif

Genetic variation associated with differential educational attainment in adults has anticipated associations with school performance in children

Genome-wide association study results have yielded evidence for the association of common genetic variants with crude measures of completed educational attainment in adults. Whilst informative, these results do not inform as to the mechanism of these effects or their presence at earlier ages and where educational performance is more routinely and more precisely assessed. Single nucleotide polymorphisms exhibiting genome-wide significant associations with adult educational attainment were combined to derive an unweighted allele score in 5,979 and 6,145 young participants from the Avon Longitudinal Study of Parents and Children with key stage 3 national curriculum test results (SATS results) available at age 13 to 14 years in English and mathematics respectively. Standardised (z-scored) results for English and mathematics showed an expected relationship with sex, with girls exhibiting an advantage over boys in English (0.433 SD (95%CI 0.395, 0.470), p<10-10) with more similar results (though in the opposite direction) in mathematics (0.042 SD (95%CI 0.004, 0.080), p = 0.030). Each additional adult educational attainment increasing allele was associated with 0.041 SD (95%CI 0.020, 0.063), p = 1.79×10-04 and 0.028 SD (95%CI 0.007, 0.050), p = 0.01 increases in standardised SATS score for English and mathematics respectively. Educational attainment is a complex multifactorial behavioural trait which has not had heritable contributions to it fully characterised. We were able to apply the results from a large study of adult educational attainment to a study of child exam performance marking events in the process of learning rather than realised adult end product. Our results support evidence for common, small genetic contributions to educational attainment, but also emphasise the likely lifecourse nature of this genetic effect. Results here also, by an alternative route, suggest that existing methods for child examination are able to recognise early life variation likely to be related to ultimate educational attainment

Systematic analysis of driverless technologies

The advent of Industry 4.0 has engendered opportunities for a coalescence of digital technologies that collectively enable driverless vehicles to operate during the construction and use of a highway. Yet, hitherto scant research has been conducted to review these collective developments and/or sample construction practitioner opinion on them. This study aims to present a systematic review of extant literature on the application of driverless technologies in civil engineering and in particular, the highways infrastructure sector and offers insight into the limitations of associated barriers to full adoption, namely, current technological development processes, legal deficiencies and societal concerns. In so doing, this work presents a vignette of contemporary developments augmented by a critical analysis from practitioners’ perceptions. Design/methodology/approach A mixed philosophical methodological approach is adopted for this inductive research study. Interpretivism is used to critically analyse the literature and post-positivism to perform content analysis of the literature and synthesis of the discourse with practitioners. A total of 44 related papers published between 1998 and 2019 have been included in this study. Emergent themes identified from literature are then discussed in some further detail, namely, 1) automation and robotics; 2) case studies and simulations; and 3) safety and ergonomics). A focus group is then held with leading industrialists to discuss their experiences of advanced driverless technology applications in practice. Based upon a culmination of emergent evidence, a conceptual model of prevailing barriers is then developed to further elucidate upon the challenges facing the highways infrastructure sector. Findings Research into driverless technologies within the highways infrastructure sector has received relatively scant academic attention. Hitherto, most advancements made have stemmed from multidisciplinary teams consisting of engineering, information technology and social scientist researchers. There is insufficient supporting evidence of civil engineering and construction academics input into developments made – suggesting that prototype products often fail to adequately consider practical applications in the highways infrastructure sector at the design and use case stage. This view is substantiated by feedback from leading industry experts who participated in unstructured telephone interviews. Their feedback suggests that practical applications of products have been beset with problems, thus creating a perception that advanced technologies are largely “unusable” within the highways infrastructure sector and so are unsuitable for large-scale (and particularly bespoke) industrial applications. Originality/value This research critically synthesises the prevailing scientific discourse within extant literature on driverless technologies implemented but also garners practitioner feedback from leading UK industrialists on their applications in practice. Hitherto, this combined analysis approach has been rarely used in spite of it having significant advantages of tacit knowledge reflection on technologies used, where such can be used as a basis for further informed discourse and/or development. Moreover, this work culminates in a conceptual model that acts as a catalyst for future research investigations

Noise Kernel and Stress Energy Bi-Tensor of Quantum Fields in Hot Flat Space and Gaussian Approximation in the Optical Schwarzschild Metric

Continuing our investigation of the regularization of the noise kernel in curved spacetimes [N. G. Phillips and B. L. Hu, Phys. Rev. D {\bf 63}, 104001 (2001)] we adopt the modified point separation scheme for the class of optical spacetimes using the Gaussian approximation for the Green functions a la Bekenstein-Parker-Page. In the first example we derive the regularized noise kernel for a thermal field in flat space. It is useful for black hole nucleation considerations. In the second example of an optical Schwarzschild spacetime we obtain a finite expression for the noise kernel at the horizon and recover the hot flat space result at infinity. Knowledge of the noise kernel is essential for studying issues related to black hole horizon fluctuations and Hawking radiation backreaction. We show that the Gaussian approximated Green function which works surprisingly well for the stress tensor at the Schwarzschild horizon produces significant error in the noise kernel there. We identify the failure as occurring at the fourth covariant derivative order.Comment: 21 pages, RevTeX