Simulating Turbulence Using the Astrophysical Discontinuous Galerkin Code TENET

In astrophysics, the two main methods traditionally in use for solving the Euler equations of ideal fluid dynamics are smoothed particle hydrodynamics and finite volume discretization on a stationary mesh. However, the goal to efficiently make use of future exascale machines with their ever higher degree of parallel concurrency motivates the search for more efficient and more accurate techniques for computing hydrodynamics. Discontinuous Galerkin (DG) methods represent a promising class of methods in this regard, as they can be straightforwardly extended to arbitrarily high order while requiring only small stencils. Especially for applications involving comparatively smooth problems, higher-order approaches promise significant gains in computational speed for reaching a desired target accuracy. Here, we introduce our new astrophysical DG code TENET designed for applications in cosmology, and discuss our first results for 3D simulations of subsonic turbulence. We show that our new DG implementation provides accurate results for subsonic turbulence, at considerably reduced computational cost compared with traditional finite volume methods. In particular, we find that DG needs about 1.8 times fewer degrees of freedom to achieve the same accuracy and at the same time is more than 1.5 times faster, confirming its substantial promise for astrophysical applications.Comment: 21 pages, 7 figures, to appear in Proceedings of the SPPEXA symposium, Lecture Notes in Computational Science and Engineering (LNCSE), Springe

The equation of state for two flavor QCD at N_t=6

We calculate the two flavor equation of state for QCD on lattices with lattice spacing a=(6T)^{-1} and find that cutoff effects are substantially reduced compared to an earlier study using a=(4T)^{-1}. However, it is likely that significant cutoff effects remain. We fit the lattice data to expected forms of the free energy density for a second order phase transition at zero-quark-mass, which allows us to extrapolate the equation of state to m_q=0 and to extract the speed of sound. We find that the equation of state depends weakly on the quark mass for small quark mass.Comment: 24 pages, latex, 11 postscipt figure

The deconfining phase transition in full QCD with two dynamical flavors

We investigate the deconfining phase transition in SU(3) pure gauge theory and in full QCD with two flavors of staggered fermions. The phase transition is detected by measuring the free energy in presence of an abelian monopole background field. In the pure gauge case our finite size scaling analysis is in agreement with the well known presence of a weak first order phase transition. In the case of 2 flavors full QCD we find, using the standard pure gauge and staggered fermion actions, that the phase transition is consistent with weak first order, contrary to the expectation of a crossover for not too large quark masses and in agreement with results obtained by the Pisa group.Comment: 23 pages, 11 figures, 4 tables (minor typos corrected, references updated, accepted for publication on JHEP

Resummations of free energy at high temperature

We discuss resummation strategies for free energy in quantum field theories at nonzero temperatures T. We point out that resummations should be performed for the short- and long-distance parts separately in order to avoid spurious interference effects and double-counting. We then discuss and perform Pade resummations of these two parts for QCD at high T. The resummed results are almost invariant under variation of the renormalization and factorization scales. We perform the analysis also in the case of the massless scalar $\phi^4$ theory.Comment: 16 pages, revtex4, 15 eps-figures; minor typographic errors corrected; the version as it appears in Phys.Rev.

Production and Clinical Evaluation of Norwalk GI.1 Virus Lot 001-09NV in Norovirus Vaccine Development

Background: Human noroviruses (HuNoV) are the leading cause of gastroenteritis. No vaccine is currently available to prevent norovirus illness or infection. Safe, infectious challenge strains are needed to assess vaccine efficacy in the controlled human infection model (CHIM). Methods: A stock of HuNoV strain Norwalk virus ([NV] GI.1) was prepared. Healthy, genetically susceptible adults were inoculated with NV Lot 001-09NV and monitored for infection, gastroenteritis symptoms, and immune responses. Results: Lot 001-09NV induced gastroenteritis in 9 (56%) and infection in 11 (69%) of 16 genetically susceptible subjects. All infected subjects developed strong immune responses to GI.1 with a 30-fold (geometric mean titer) increase in blocking titers (BT50) and a 161-fold increase in GI.1-specific immunoglobulin (Ig)G titers when compared with baseline. GI.1-specific cellular responses in peripheral blood were observed 9 days postchallenge with an average of 3253 IgA and 1227 IgG antibody-secreting cells per million peripheral blood mononuclear cells. Conclusions: GI.1 Lot 001-09NV appears to be similar in virulence to previous passages of NV strain 8fIIa. The safety profile, attack rate, and duration of illness make GI.1 Lot 001-09NV a useful challenge strain for future vaccine studies aimed at establishing immune correlates

Exome-wide meta-analysis identifies rare 3'-UTR variant in ERCC1/CD3EAP associated with symptoms of sleep apnea

Obstructive sleep apnea (OSA) is a common sleep breathing disorder associated with an increased risk of cardiovascular and cerebrovascular diseases and mortality. Although OSA is fairly heritable (~40%), there have been only few studies looking into the genetics of OSA. In the present study, we aimed to identify genetic variants associated with symptoms of sleep apnea by performing a whole-exome sequence meta-analysis of symptoms of sleep apnea in 1,475 individuals of European descent. We identified 17 rare genetic variants with at least suggestive evidence of significance. Replication in an independent dataset confirmed the association of a rare genetic variant (rs2229918; minor allele frequency = 0.3%) with symptoms of sleep apnea (p-valuemeta = 6.98 × 10-9, ßmeta = 0.99). Rs2229918 overlaps with the 3' untranslated regions of ERCC1 and CD3EAP genes on chromosome 19q13. Both genes are expressed in tissues in the neck area, such as the tongue, muscles, cartilage and the trachea. Further, CD3EAP is localized in the nucleus and mitochondria and involved in the tumor necrosis factor-alpha/nuclear factor kappa B signaling pathway. Our results and biological functions of CD3EAP/ERCC1 genes suggest that the 19q13 locus is interesting for further OSA research

‘O sibling, where art thou?’ – a review of avian sibling recognition with respect to the mammalian literature

Avian literature on sibling recognition is rare compared to that developed by mammalian researchers. We compare avian and mammalian research on sibling recognition to identify why avian work is rare, how approaches differ and what avian and mammalian researchers can learn from each other. Three factors: (1) biological differences between birds and mammals, (2) conceptual biases and (3) practical constraints, appear to influence our current understanding. Avian research focuses on colonial species because sibling recognition is considered adaptive where ‘mixing potential’ of dependent young is high; research on a wider range of species, breeding systems and ecological conditions is now needed. Studies of acoustic recognition cues dominate avian literature; other types of cues (e.g. visual, olfactory) deserve further attention. The effect of gender on avian sibling recognition has yet to be investigated; mammalian work shows that gender can have important influences. Most importantly, many researchers assume that birds recognise siblings through ‘direct familiarisation’ (commonly known as associative learning or familiarity); future experiments should also incorporate tests for ‘indirect familiarisation’ (commonly known as phenotype matching). If direct familiarisation proves crucial, avian research should investigate how periods of separation influence sibling discrimination. Mammalian researchers typically interpret sibling recognition in broad functional terms (nepotism, optimal outbreeding); some avian researchers more successfully identify specific and testable adaptive explanations, with greater relevance to natural contexts. We end by reporting exciting discoveries from recent studies of avian sibling recognition that inspire further interest in this topic

The emergence of a new source of X-rays from the binary neutron star merger GW170817

The binary neutron-star (BNS) merger GW170817 is the first celestial object from which both gravitational waves (GWs) and light have been detected enabling critical insight on the pre-merger (GWs) and post-merger (light) physical properties of these phenomena. For the first $\sim 3$ years after the merger the detected radio and X-ray radiation has been dominated by emission from a structured relativistic jet initially pointing $\sim 15-25$ degrees away from our line of sight and propagating into a low-density medium. Here we report on observational evidence for the emergence of a new X-ray emission component at $\delta t>900$ days after the merger. The new component has luminosity $L_x \approx 5\times 10^{38}\rm{erg s^{-1}}$ at 1234 days, and represents a $\sim 3.5\sigma$ - $4.3\sigma$ excess compared to the expectations from the off-axis jet model that best fits the multi-wavelength afterglow of GW170817 at earlier times. A lack of detectable radio emission at 3 GHz around the same time suggests a harder broadband spectrum than the jet afterglow. These properties are consistent with synchrotron emission from a mildly relativistic shock generated by the expanding merger ejecta, i.e. a kilonova afterglow. In this context our simulations show that the X-ray excess supports the presence of a high-velocity tail in the merger ejecta, and argues against the prompt collapse of the merger remnant into a black hole. However, radiation from accretion processes on the compact-object remnant represents a viable alternative to the kilonova afterglow. Neither a kilonova afterglow nor accretion-powered emission have been observed before.Comment: 66 pages, 12 figures, Submitte

Quantum walks: a comprehensive review

Quantum walks, the quantum mechanical counterpart of classical random walks, is an advanced tool for building quantum algorithms that has been recently shown to constitute a universal model of quantum computation. Quantum walks is now a solid field of research of quantum computation full of exciting open problems for physicists, computer scientists, mathematicians and engineers. In this paper we review theoretical advances on the foundations of both discrete- and continuous-time quantum walks, together with the role that randomness plays in quantum walks, the connections between the mathematical models of coined discrete quantum walks and continuous quantum walks, the quantumness of quantum walks, a summary of papers published on discrete quantum walks and entanglement as well as a succinct review of experimental proposals and realizations of discrete-time quantum walks. Furthermore, we have reviewed several algorithms based on both discrete- and continuous-time quantum walks as well as a most important result: the computational universality of both continuous- and discrete- time quantum walks.Comment: Paper accepted for publication in Quantum Information Processing Journa