Cannabis use and risk of schizophrenia: a Mendelian randomization study.

Cannabis use is observationally associated with an increased risk of schizophrenia, but whether the relationship is causal is not known. Using a genetic approach, we took 10 independent genetic variants previously identified to associate with cannabis use in 32 330 individuals to determine the nature of the association between cannabis use and risk of schizophrenia. Genetic variants were employed as instruments to recapitulate a randomized controlled trial involving two groups (cannabis users vs nonusers) to estimate the causal effect of cannabis use on risk of schizophrenia in 34 241 cases and 45 604 controls from predominantly European descent. Genetically-derived estimates were compared with a meta-analysis of observational studies reporting ever use of cannabis and risk of schizophrenia or related disorders. Based on the genetic approach, use of cannabis was associated with increased risk of schizophrenia (odds ratio (OR) of schizophrenia for users vs nonusers of cannabis: 1.37; 95% confidence interval (CI), 1.09-1.67; P-value=0.007). The corresponding estimate from observational analysis was 1.43 (95% CI, 1.19-1.67; P-value for heterogeneity =0.76). The genetic markers did not show evidence of pleiotropic effects and accounting for tobacco exposure did not alter the association (OR of schizophrenia for users vs nonusers of cannabis, adjusted for ever vs never smoker: 1.41; 95% CI, 1.09-1.83). This adds to the substantial evidence base that has previously identified cannabis use to associate with increased risk of schizophrenia, by suggesting that the relationship is causal. Such robust evidence may inform public health messages about cannabis use, especially regarding its potential mental health consequences

Sequential Decay Distortion of Goldhaber Model Widths for Spectator Fragments

Momentum widths of the primary fragments and observed final fragments have been investigated within the framework of an Antisymmetrized Molecular Dynamics transport model code (AMD-V) with a sequential decay afterburner (GEMINI). It is found that the secondary evaporation effects cause the values of a reduced momentum width, $\sigma_0$, derived from momentum widths of the final fragments to be significantly less than those appropriate to the primary fragment but close to those observed in many experiments. Therefore, a new interpretation for experiemental momentum widths of projectile-like fragments is presented.Comment: 4 pages, 3 figs. Accepted for publication in Phys. Rev. C as a Rapid Communicatio

Sequential Decay Distortion of Goldhaber Model Widths for Spectator Fragments

Momentum widths of the primary fragments and observed final fragments have been investigated within the framework of an Antisymmetrized Molecular Dynamics transport model code (AMD-V) with a sequential decay afterburner (GEMINI). It is found that the secondary evaporation effects cause the values of a reduced momentum width, $\sigma_0$, derived from momentum widths of the final fragments to be significantly less than those appropriate to the primary fragment but close to those observed in many experiments. Therefore, a new interpretation for experiemental momentum widths of projectile-like fragments is presented.Comment: 4 pages, 3 figs. Accepted for publication in Phys. Rev. C as a Rapid Communicatio

Thermodynamics of Large-N_f QCD at Finite Chemical Potential

We extend the previously obtained results for the thermodynamic potential of hot QCD in the limit of large number of fermions to non-vanishing chemical potential. We give exact results for the thermal pressure in the entire range of temperature and chemical potential for which the presence of a Landau pole is negligible numerically. In addition we compute linear and non-linear quark susceptibilities at zero chemical potential, and the entropy at small temperatures. We compare with the available perturbative results and determine their range of applicability. Our numerical accuracy is sufficiently high to check and verify existing results, including the recent perturbative results by Vuorinen on quark number susceptibilities and the older results by Freedman and McLerran on the pressure at zero temperature and high chemical potential. We also obtain a number of perturbative coefficients at sixth order in the coupling that have not yet been calculated analytically. In the case of both non-zero temperature and non-zero chemical potential, we investigate the range of validity of a scaling behaviour noticed recently in lattice calculations by Fodor, Katz, and Szabo at moderately large chemical potential and find that it breaks down rather abruptly at $\mu_q \gtrsim \pi T$, which points to a presumably generic obstruction for extrapolating data from small to large chemical potential. At sufficiently small temperatures $T \ll \mu_q$, we find dominating non-Fermi-liquid contributions to the interaction part of the entropy, which exhibits strong nonlinearity in the temperature and an excess over the free-theory value.Comment: 18 pages, 7 figures, JHEP style; v2: several updates, rewritten and extended sect. 3.4 covering now "Entropy at small temperatures and non-Fermi-liquid behaviour"; v3: additional remarks at the end of sect. 3.4; v4: minor corrections and additions (version to appear in JHEP

New Insights into White-Light Flare Emission from Radiative-Hydrodynamic Modeling of a Chromospheric Condensation

(abridged) The heating mechanism at high densities during M dwarf flares is poorly understood. Spectra of M dwarf flares in the optical and near-ultraviolet wavelength regimes have revealed three continuum components during the impulsive phase: 1) an energetically dominant blackbody component with a color temperature of T $\sim$ 10,000 K in the blue-optical, 2) a smaller amount of Balmer continuum emission in the near-ultraviolet at lambda $<$ 3646 Angstroms and 3) an apparent pseudo-continuum of blended high-order Balmer lines. These properties are not reproduced by models that employ a typical "solar-type" flare heating level in nonthermal electrons, and therefore our understanding of these spectra is limited to a phenomenological interpretation. We present a new 1D radiative-hydrodynamic model of an M dwarf flare from precipitating nonthermal electrons with a large energy flux of $10^{13}$ erg cm$^{-2}$ s$^{-1}$. The simulation produces bright continuum emission from a dense, hot chromospheric condensation. For the first time, the observed color temperature and Balmer jump ratio are produced self-consistently in a radiative-hydrodynamic flare model. We find that a T $\sim$ 10,000 K blackbody-like continuum component and a small Balmer jump ratio result from optically thick Balmer and Paschen recombination radiation, and thus the properties of the flux spectrum are caused by blue light escaping over a larger physical depth range compared to red and near-ultraviolet light. To model the near-ultraviolet pseudo-continuum previously attributed to overlapping Balmer lines, we include the extra Balmer continuum opacity from Landau-Zener transitions that result from merged, high order energy levels of hydrogen in a dense, partially ionized atmosphere. This reveals a new diagnostic of ambient charge density in the densest regions of the atmosphere that are heated during dMe and solar flares.Comment: 50 pages, 2 tables, 13 figures. Accepted for publication in the Solar Physics Topical Issue, "Solar and Stellar Flares". Version 2 (June 22, 2015): updated to include comments by Guest Editor. The final publication is available at Springer via http://dx.doi.org/10.1007/s11207-015-0708-

Electroweak Corrections to the Charged Higgs Boson Decay into Chargino and Neutralino

The electroweak corrections to the partial widths of the $H^+ \to \tilde{\chi}^+_i \tilde{\chi}_j^0 (i=1,j=1,2)$ decays including one-loop diagrams of the third generation quarks and squarks, are investigated within the Supersymmetric Standard Model. The relative corrections can reach the values about 10%, therefore they should be taken into account for the precise experimental measurement at future colliders.Comment: 21 pages, 6 eps figures, 1 Latex fil

Measurement of the branching fraction for Υ(1S)→τ+τ−\Upsilon (1S) \to \tau^+ \tau^-

We have studied the leptonic decay of the $\Upsilon (1S)$ resonance into tau pairs using the CLEO II detector. A clean sample of tau pair events is identified via events containing two charged particles where exactly one of the particles is an identified electron. We find $B(\Upsilon(1S) \to \tau^+ \tau^-) = (2.61~\pm~0.12~{+0.09\atop{-0.13}})$. The result is consistent with expectations from lepton universality.Comment: 9 pages, RevTeX, two Postscript figures available upon request, CLNS 94/1297, CLEO 94-20 (submitted to Physics Letters B

Study of the B^0 Semileptonic Decay Spectrum at the Upsilon(4S) Resonance

We have made a first measurement of the lepton momentum spectrum in a sample of events enriched in neutral B's through a partial reconstruction of B0 --> D*- l+ nu. This spectrum, measured with 2.38 fb**-1 of data collected at the Upsilon(4S) resonance by the CLEO II detector, is compared directly to the inclusive lepton spectrum from all Upsilon(4S) events in the same data set. These two spectra are consistent with having the same shape above 1.5 GeV/c. From the two spectra and two other CLEO measurements, we obtain the B0 and B+ semileptonic branching fractions, b0 and b+, their ratio, and the production ratio f+-/f00 of B+ and B0 pairs at the Upsilon(4S). We report b+/b0=0.950 (+0.117-0.080) +- 0.091, b0 = (10.78 +- 0.60 +- 0.69)%, and b+ = (10.25 +- 0.57 +- 0.65)%. b+/b0 is equivalent to the ratio of charged to neutral B lifetimes, tau+/tau0.Comment: 14 page, postscript file also available at http://w4.lns.cornell.edu/public/CLN

Measurement of the Decay Asymmetry Parameters in Λc+→Λπ+\Lambda_c^+ \to \Lambda\pi^+ and Λc+→Σ+π0\Lambda_c^+ \to \Sigma^+\pi^0

We have measured the weak decay asymmetry parameters (\aLC ) for two \LC\ decay modes. Our measurements are \aLC = -0.94^{+0.21+0.12}_{-0.06-0.06} for the decay mode $\Lambda_c^+ \to \Lambda\pi^+$ and \aLC = -0.45\pm 0.31 \pm 0.06 for the decay mode $\Lambda_c \to \Sigma^+\pi^0$. By combining these measurements with the previously measured decay rates, we have extracted the parity-violating and parity-conserving amplitudes. These amplitudes are used to test models of nonleptonic charmed baryon decay.Comment: 11 pages including the figures. Uses REVTEX and psfig macros. Figures as uuencoded postscript. Also available as http://w4.lns.cornell.edu/public/CLNS/1995/CLNS95-1319.p

Observation of the Ξc+\Xi_c^+ Charmed Baryon Decays to Σ+K−π+\Sigma^+ K^-\pi^+, Σ+Kˉ∗0\Sigma^+ \bar{K}^{*0}, and ΛK−π+π+\Lambda K^-\pi^+\pi^+

We have observed two new decay modes of the charmed baryon $\Xi_c^+$ into $\Sigma^+ K^-\pi^+$ and $\Sigma^+ \bar{K}^{*0}$ using data collected with the CLEO II detector. We also present the first measurement of the branching fraction for the previously observed decay mode $\Xi_c^+\to\Lambda K^-\pi^+\pi^+$. The branching fractions for these three modes relative to $\Xi_c^+\to\Xi^-\pi^+\pi^+$ are measured to be $1.18 \pm 0.26 \pm 0.17$, $0.92 \pm 0.27 \pm 0.14$, and $0.58 \pm 0.16 \pm 0.07$, respectively.Comment: 12 page uuencoded postscript file, postscript file also available through http://w4.lns.cornell.edu/public/CLN