The LHCb upgrade I

The LHCb upgrade represents a major change of the experiment. The detectors have been almost completely renewed to allow running at an instantaneous luminosity five times larger than that of the previous running periods. Readout of all detectors into an all-software trigger is central to the new design, facilitating the reconstruction of events at the maximum LHC interaction rate, and their selection in real time. The experiment's tracking system has been completely upgraded with a new pixel vertex detector, a silicon tracker upstream of the dipole magnet and three scintillating fibre tracking stations downstream of the magnet. The whole photon detection system of the RICH detectors has been renewed and the readout electronics of the calorimeter and muon systems have been fully overhauled. The first stage of the all-software trigger is implemented on a GPU farm. The output of the trigger provides a combination of totally reconstructed physics objects, such as tracks and vertices, ready for final analysis, and of entire events which need further offline reprocessing. This scheme required a complete revision of the computing model and rewriting of the experiment's software

Social Media Guidelines for Anatomists

Social Media has changed the way that individuals interact with each other ‐ it has brought considerable benefits, yet also some challenges. Social media in anatomy has enabled anatomists all over the world to engage, interact and form new collaborations that otherwise would not have been possible. In a relatively small discipline where individuals may be working as the only anatomist in an institution, having such a virtual community can be important. Social media is also being used as a means for anatomists to communicate with the current generation of students as well as members of the public. Posting appropriate content is one of the challenges raised by social media use in anatomy. Human cadaveric material is frequently shared on social media and there is divided opinion among anatomists on whether or not such content is appropriate. This article explores the uses and challenges of social media use in the field of anatomy and outlines guidelines on how social media can be used by anatomists globally, while maintaining professional and ethical standards. Creating global guidelines has shown to be difficult due to the differences in international law for the use of human tissue and also the irregularities in acquiring informed consent for capturing and sharing cadaveric images. These nuances may explain why cadaveric images are frequently shared on social media. This article proposes that as standard practice, anatomists obtain informed consent from donors before sharing images of cadaveric material on social media and ensure posts include a statement stating the same

Exome Sequencing in an Admixed Isolated Population Indicates NFXL1 Variants Confer a Risk for Specific Language Impairment

Contains fulltext : 144496.pdf (publisher's version ) (Open Access)Children affected by Specific Language Impairment (SLI) fail to acquire age appropriate language skills despite adequate intelligence and opportunity. SLI is highly heritable, but the understanding of underlying genetic mechanisms has proved challenging. In this study, we use molecular genetic techniques to investigate an admixed isolated founder population from the Robinson Crusoe Island (Chile), who are affected by a high incidence of SLI, increasing the power to discover contributory genetic factors. We utilize exome sequencing in selected individuals from this population to identify eight coding variants that are of putative significance. We then apply association analyses across the wider population to highlight a single rare coding variant (rs144169475, Minor Allele Frequency of 4.1% in admixed South American populations) in the NFXL1 gene that confers a nonsynonymous change (N150K) and is significantly associated with language impairment in the Robinson Crusoe population (p = 2.04 x 10-4, 8 variants tested). Subsequent sequencing of NFXL1 in 117 UK SLI cases identified four individuals with heterozygous variants predicted to be of functional consequence. We conclude that coding variants within NFXL1 confer an increased risk of SLI within a complex genetic model

Homozygous microdeletion of exon 5 in znf277 in a girl with specific language impairment

Contains fulltext : 133117.pdf (publisher's version ) (Open Access

Types for Security in a Mobile World

Abstract. Our society is increasingly moving towards richer forms of information exchange where mobility of processes and devices plays a prominent role. This tendency has prompted the academic community to study the security problems arising from such mobile environments, and in particular, the security policies regulating who can access the information in question. In this paper we propose a mechanisms for specifying access privileges based on a combination of the identity of the user seeking access, its credentials, and the location from which he seeks it, within a reconfigurable nested structure. We define BACIR, a boxed ambient calculus extended with a Distributed Role-Based Access Control mechanism where each ambient controls its own access policy. A process in BACIR is associated with an owner and a set of activated roles that grant permissions for mobility and communication. The calculus includes primitives to activate and deactivate roles. The behavior of these primitives is determined by the process’s owner, its current location and its currently activated roles. We consider two forms of security violations that our type system prevents: 1) attempting to move into an ambient without having the authorizing roles granting entry activated and 2) trying to use a communication port without having the roles required for access activated. We accomplish 1) and 2) by giving a static type system, an untyped transition semantics, and a typed transition semantics. We then show that a well-typed program never violates the dynamic security checks.