427 research outputs found

    Archives of the Daughters of Charity, Northeast Province, Albany, New York

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    This is an inventory of the archives of the Northeast Province of the Daughters of Charity. It includes letters of Vincent de Paul; books and pamphlets by and about him; letters of Louise de Marillac and documents pertaining to her; books and pamphlets by and about her; letters of Elizabeth Ann Seton; books and pamphlets about her; conferences and circulars of the superiors general; the personal correspondence of Superior General William Slattery; books and other materials on the Congregation’s saints, blessed, and notable others; histories and annals of the Congregation; materials on the Vincentians in the United States; items relating to the Daughters of Charity’s government; materials on Catherine Laboure and other notable figures of the Daughters of charity; circulars and other items, including books, by and about the superioresses; books, pamphlets, etc. on the Daughters’ history; materials relating to early superiors and superioresses in the United States; items related to the Northeast Province’s government, history, and apostolates; and more

    On the Progenitors of Core-Collapse Supernovae

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    Theory holds that a star born with an initial mass between about 8 and 140 times the mass of the Sun will end its life through the catastrophic gravitational collapse of its iron core to a neutron star or black hole. This core collapse process is thought to usually be accompanied by the ejection of the star's envelope as a supernova. This established theory is now being tested observationally, with over three dozen core-collapse supernovae having had the properties of their progenitor stars directly measured through the examination of high-resolution images taken prior to the explosion. Here I review what has been learned from these studies and briefly examine the potential impact on stellar evolution theory, the existence of "failed supernovae", and our understanding of the core-collapse explosion mechanism.Comment: 7 Pages, invited review accepted for publication by Astrophysics and Space Science (special HEDLA 2010 issue

    The shape of SN 1993J re-analysed

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    SN 1993J is one of the best-studied Type IIb supernovae. Spectropolarimetric data analyses were published over two decades ago at a time when the field of supernova spectropolarimetry was in its infancy. Here, we present a new analysis of the spectropolarimetric data of SN 1993J and an improved estimate of its interstellar polarization (ISP) as well as a critical review of ISP removal techniques employed in the field. The polarization of SN 1993J is found to show significant alignment on the q − u plane, suggesting the presence of a dominant axis and therefore of continuum polarization. We also see strong line polarization features, including H ÎČ, He I λ5876, H α, He I λ6678, He I λ7065, and high velocity (HV) components of He I λ5876 and H α. SN 1993J is therefore the second example of a stripped-envelope supernova, alongside iPTF13bvn, with prominent HV helium polarization features, and the first to show a likely HV H α contribution. Overall, we determine that the observed features can be interpreted as the superposition of anisotropically distributed line forming regions over ellipsoidal ejecta. We cannot exclude the possibility of an off-axis energy source within the ejecta. These data demonstrate the rich structures that are inaccessible if solely considering the flux spectra but can be probed by spectropolarimetric observations. In future studies, the new ISP corrected data can be used in conjunction with 3D radiative transfer models to better map the geometry of the ejecta of SN 1993J

    Randomized multicentre pilot study of sacubitril/valsartan versus irbesartan in patients with chronic kidney disease: United Kingdom Heart and Renal Protection (HARP)- III—rationale, trial design and baseline data

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    BACKGROUND: Patients with chronic kidney disease (CKD) are at risk of progression to end-stage renal disease and cardiovascular disease. Data from other populations and animal experiments suggest that neprilysin inhibition (which augments the natriuretic peptide system) may reduce these risks, but clinical trials among patients with CKD are required to test this hypothesis. METHODS: UK Heart and Renal Protection III (HARP-III) is a multicentre, double-blind, randomized controlled trial comparing sacubitril/valsartan 97/103 mg two times daily (an angiotensin receptor-neprilysin inhibitor) with irbesartan 300 mg one time daily among 414 patients with CKD. Patients ≄18 years of age with an estimated glomerular filtration rate (eGFR) of ≄45 but <60 mL/min/1.73 m2 and urine albumin:creatinine ratio (uACR) >20 mg/mmol or eGFR ≄20 but <45 mL/min/1.73 m2 (regardless of uACR) were invited to be screened. Following a 4- to 7-week pre-randomization single-blind placebo run-in phase (during which any current renin-angiotensin system inhibitors were stopped), willing and eligible participants were randomly assigned either sacubitril/valsartan or irbesartan and followed-up for 12 months. The primary aim was to compare the effects of sacubitril/valsartan and irbesartan on measured GFR after 12 months of therapy. Important secondary outcomes include effects on albuminuria, change in eGFR over time and the safety and tolerability of sacubitril/valsartan in CKD. RESULTS: Between November 2014 and January 2016, 620 patients attended a screening visit and 566 (91%) entered the pre-randomization run-in phase. Of these, 414 (73%) participants were randomized (mean age 63 years; 72% male). The mean eGFR was 34.0 mL/min/1.73 m2 and the median uACR was 58.5 mg/mmol. CONCLUSIONS: UK HARP-III will provide important information on the short-term effects of sacubitril/valsartan on renal function, tolerability and safety among patients with CKD

    Supporting ethical, independent learning behavior among university students in the Arabian Gulf

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    © Springer International Publishing Switzerland 2014. Students in the Arabian Gulf region and the world over confront plagiarism temptations wittingly or unwittingly due to the multitude of free and easily available electronic sources of information. Rather than develop independent learning skills and academic integrity, students are often taken advantage of by essay mills that sell readymade essays. Instructors at times compound the problem by repeatedly recycling course assignments and tasks. Furthermore, there have been reports of the use of social networking sites for outsourcing and contract cheating in student assignments. This paper discusses how educators in an institution of higher learning in the UAE assist students to develop good academic skills. Data collection is with the use of an online survey questionnaire. Concurring with Wheeler and Anderson (2010) who call for appropriate and comprehensive institutional policies and guidelines for dealing with plagiarism, practical examples of the processes and procedures used at these institutions are provided

    The Use of Statistical Quality Control Charts to Evaluate Changes in Individual Performance

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    An employee's readiness to perform (RTP) has become an important issue facing today's industries. Some industries have turned to cognitive performance testing to provide answers regarding their employee's abilities to work safely and effectively. Such tests are designed to assess the employee's current state of preparedness for work without identifying specific causes for any noted performance impairment. This paper evaluates performance-based RTP tests with regard to the metrics by which performance change is judged. In addition to evaluating a current commonly used metric, several statistical quality control charts were examined as alternate methods for identifying impaired performance. Traditional Shewhart charts were used as well as exponentially weighted moving average charts and cumulative sum charts. A comparative analysis of the various methods revealed that control chart techniques provided superior effectiveness over the current method. Specifically, exponentially weighted moving average charts were effective in evaluating continuous performance measures and Shewhart p charts were effective in evaluating discrete measure data.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

    Blood pressure in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) controversies conference

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    In September 2017, KDIGO (Kidney Disease: Improving Global Outcomes) convened a Controversies Conference titled Blood Pressure in Chronic Kidney Disease (CKD). The purpose of the meeting was to consider which recommendations from the 2012 KDIGO Clinical Practice Guideline for the Management of Blood Pressure in CKD should be reevaluated based on new evidence from clinical trials. Participants included a multidisciplinary panel of clinical and scientific experts. Discussions focused on the optimal means for measuring blood pressure (BP) as well as managing BP in CKD patients. Consistent with the 2012 Guideline, the conference did not address BP management in patients on maintenance dialysis

    Field Theoretical Quantum Effects on the Kerr Geometry

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    We study quantum aspects of the Einstein gravity with one time-like and one space-like Killing vector commuting with each other. The theory is formulated as a \coset nonlinear σ\sigma-model coupled to gravity. The quantum analysis of the nonlinear σ\sigma-model part, which includes all the dynamical degrees of freedom, can be carried out in a parallel way to ordinary nonlinear σ\sigma-models in spite of the existence of an unusual coupling. This means that we can investigate consistently the quantum properties of the Einstein gravity, though we are limited to the fluctuations depending only on two coordinates. We find the forms of the beta functions to all orders up to numerical coefficients. Finally we consider the quantum effects of the renormalization on the Kerr black hole as an example. It turns out that the asymptotically flat region remains intact and stable, while, in a certain approximation, it is shown that the inner geometry changes considerably however small the quantum effects may be.Comment: 16 pages, LaTeX. The hep-th number added on the cover, and minor typos correcte

    Survival on four-times-per-week compared with three times a week haemodialysis in high ultrafiltration patients : an observational study

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    Background The harm caused by the long interdialytic interval in three-times-per-week haemodialysis regimens (3×WHD) may relate to fluid accumulation and associated high ultrafiltration rate (UFR). Four-times-per-week haemodialysis (4×WHD) may offer a solution, but its impact on mortality, hospitalization and vascular access complications is unknown. Methods From the AROii cohort of incident in-centre haemodialysis patients, 3×WHD patients with a UFR >10 mL/kg/h were identified. The hazard for the outcomes of mortality, hospitalization and vascular access complications in those who switched to 4×WHD compared with staying on 3×WHD was estimated using a marginal structural Cox proportional hazards model. Adjustment included baseline patient and treatment characteristics with inverse probability weighting used to adjust for time-varying UFR and cardiovascular comorbidities. Results From 10 637 European 3×WHD patients, 3842 (36%) exceeded a UFR >10 mL/kg/h. Of these, 288 (7.5%) started 4×WHD and at baseline were more comorbid. Event rates while receiving 4×WHD compared with 3×WHD were 12.6 compared with 10.8 per 100 patient years for mortality, 0.96 compared with 0.65 per year for hospitalization and 14.7 compared with 8.0 per 100 patient years for vascular access complications. Compared with 3×WHD, the unadjusted hazard ratio (HR) for mortality on 4×WHD was 1.05 [95% confidence interval (CI) 0.78–1.42]. Following adjustment for baseline demographics, time-varying treatment probability and censoring risks, this HR was 0.73 (95% CI 0.50–1.05; P = 0.095). Despite these adjustments on 4×WHD, the HR for hospitalization remained elevated and vascular access complications were similar to 3×WHD. Conclusions This observational study was not able to demonstrate a mortality benefit in patients switched to 4×WHD. To demonstrate the true benefits of 4×WHD requires a large, well-designed clinical trial. Our data may help in the design of such a study

    Tobacco Retail Outlets, Neighborhood Deprivation and the Risk of Prenatal Smoke Exposure

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    INTRODUCTION: Smoking and smoke exposure among pregnant women remain persistent public health issues. Recent estimates suggest that approximately one out of four nonsmokers have measurable levels of cotinine, a marker indicating regular exposure to secondhand smoke. Epidemiological research has attempted to pinpoint individual-level and neighborhood-level factors for smoking during pregnancy. However, most of these studies have relied upon self-reported measures of smoking. AIMS AND METHODS: To more accurately assess smoke exposure resulting from both smoking and secondhand exposure in mothers during pregnancy, we used Bayesian regression models to estimate the association of cotinine levels with tobacco retail outlet (TRO) exposure and a neighborhood deprivation index (NDI) in six counties in North Carolina centered on Durham County. RESULTS: Results showed a significant positive association between TRO exposure (ÎČ = 0.008, 95% credible interval (CI) = [0.003, 0.013]) and log cotinine after adjusting for individual covariates (eg, age, race/ethnicity, education, marital status). TRO exposure was not significant after including the NDI, which was significantly associated with log cotinine (ÎČ = 0.143, 95% CI = [0.030, 0.267]). However, in a low cotinine stratum (indicating secondhand smoke exposure), TRO exposure was significantly associated with log cotinine (ÎČ = 0.005, 95% CI = [0.001, 0.009]), while in a high cotinine stratum (indicating active smoking), the NDI was significantly associated with log cotinine (ÎČ = 0.176, 95% CI = [0.005, 0.372]). CONCLUSIONS: In summary, our findings add to the evidence that contextual factors are important for active smoking during pregnancy. IMPLICATIONS: In this study, we found several significant associations that suggest a more nuanced understanding of the potential influence of environmental- and individual-level factors for levels of prenatal smoke exposure. Results suggested a significant positive association between TRO exposure and cotinine levels, after adjusting for the individual factors such as race, education, and marital status. Individually, NDI was similarly positively associated with cotinine levels as well. However, when combining TRO exposure alongside NDI in the same model, TROs were no longer significantly associated with overall cotinine levels
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