308 research outputs found
Believability of new diseases reported in the 2014 Surgeon General's Report on smoking: Experimental results from a national survey of US adults
Background Tobacco use is the leading cause of preventable disease and death globally. The 2014 Surgeon General's Report included new diseases linked to smoking, including liver and colon cancer, diabetes and tuberculosis. As more diseases are linked to smoking, which diseases should we communicate to the public and what message source has the most impact? Methods Data were collected through a nationally representative phone survey of US adults (N = 5014), conducted from September 2014 through May 2015. We experimentally randomized participants to a 2 (new smoking disease messages - liver and colon cancers compared to diabetes and tuberculosis) by 4 (message sources - CDC, FDA, Surgeon General, and none) experiment. The outcome was message believability. Results About half the sample was female (51.5%) and 17.8% were a current smoker. Overall, 56% of participants said the messages were very believable. Cancer messages (liver and colon cancer) were significantly more believable than messages about chronic disease (tuberculosis and diabetes), 61% vs. 52%. Smokers were less likely to report both sets of new disease messages as very believable compared to non-smokers. Significantly more smokers intending to quit (44.5%) found the messages to be very believable compared to smokers not intending to quit (22.6%). Believability did not differ by message source. Conclusion Important differences exist in believability of disease messages about new tobacco-related information. Messages emphasizing the causal link between smoking and new diseases should be considered for use in mass media campaigns
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Biogenic Versus Anthropogenic Sources of CO in the United States
Aircraft observations of carbon monoxide (CO) from the ICARTT campaign over the eastern United States in summer 2004 (July 1–August 15), interpreted with a global 3-D model of tropospheric chemistry (GEOS-Chem), show that the national anthropogenic emission inventory from the U.S. Environmental Protection Agency (93 Tg CO y−1) is too high by 60% in summer. Our best estimate of the CO anthropogenic source for the ICARTT period is 6.4 Tg CO, including 4.6 Tg from direct emission and 1.8 Tg CO from oxidation of anthropogenic volatile organic compounds (VOCs). The biogenic CO source for the same period from the oxidation of isoprene and other biogenic VOCs is 8.3 Tg CO, and is independently constrained by ICARTT observations of formaldehyde (HCHO). Anthropogenic emissions of CO in the U.S. have decreased to the point that they are now lower than the biogenic source in summer.Earth and Planetary SciencesEngineering and Applied Science
A microscopic derivation of the quantum mechanical formal scattering cross section
We prove that the empirical distribution of crossings of a "detector''
surface by scattered particles converges in appropriate limits to the
scattering cross section computed by stationary scattering theory. Our result,
which is based on Bohmian mechanics and the flux-across-surfaces theorem, is
the first derivation of the cross section starting from first microscopic
principles.Comment: 28 pages, v2: Typos corrected, layout improved, v3: Typos corrected.
Accepted for publication in Comm. Math. Phy
Constraining the expansion rate of the Universe using low-redshift ellipticals as cosmic chronometers
We present a new methodology to determine the expansion history of the
Universe analyzing the spectral properties of early type galaxies (ETG). We
found that for these galaxies the 4000\AA break is a spectral feature that
correlates with the relative ages of ETGs. In this paper we describe the
method, explore its robustness using theoretical synthetic stellar population
models, and apply it using a SDSS sample of 14 000 ETGs. Our motivation
to look for a new technique has been to minimise the dependence of the cosmic
chronometer method on systematic errors. In particular, as a test of our
method, we derive the value of the Hubble constant (stat)
(syst) (68% confidence), which is not only fully compatible with the
value derived from the Hubble key project, but also with a comparable error
budget. Using the SDSS, we also derive, assuming w=constant, a value for the
dark energy equation of state parameter (stat)
(syst). Given the fact that the SDSS ETG sample only reaches , this
result shows the potential of the method. In future papers we will present
results using the high-redshift universe, to yield a determination of H(z) up
to .Comment: 25 pages, 17 figures, JCAP accepte
A genome-wide screen for variants influencing certolizumab pegol response in a moderate to severe rheumatoid arthritis population
Certolizumab pegol (CZP) is a PEGylated Fc-free tumor necrosis factor (TNF) inhibitor antibody approved for use in the treatment of rheumatoid arthritis (RA), Crohn's disease, psoriatic arthritis, axial spondyloarthritis and psoriasis. In a clinical trial of patients with severe RA, CZP improved disease symptoms in approximately half of patients. However, variability in CZP efficacy remains a problem for clinicians, thus, the aim of this study was to identify genetic variants predictive of CZP response. We performed a genome-wide association study (GWAS) of 302 RA patients treated with CZP in the REALISTIC trial to identify common single nucleotide polymorphisms (SNPs) associated with treatment response. Wholeexome sequencing was also performed for 74 CZP extreme responders and non-responders within the same population, as well as 1546 population controls. No common SNPs or rare functional variants were significantly associated with CZP response, though a non-significant enrichment in the RA-implicated KCNK5 gene was observed. Two SNPs near spondin- 1 and semaphorin-4G approached genome-wide significance. The results of the current study did not provide an unambiguous predictor of CZP response
Large-scale pathways-based association study in amyotrophic lateral sclerosis
Sporadic amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease, most likely results from complex genetic and environmental interactions. Although a number of association studies have been performed in an effort to find genetic components of sporadic ALS, most of them resulted in inconsistent findings due to a small number of genes investigated in relatively small sample sizes, while the replication of results was rarely attempted. Defects in retrograde axonal transport, vesicle trafficking and xenobiotic metabolism have been implicated in neurodegeneration and motor neuron death both in human disease and animal models. To assess the role of common genetic variation in these pathways in susceptibility to sporadic ALS, we performed a pathway-based candidate gene case-control association study with replication. Furthermore, we determined reliability of whole genome amplified DNA in a large-scale association study. In the first stage of the study, 1277 putative functional and tagging SNPs in 134 genes spanning 8.7 Mb were genotyped in 822 British sporadic ALS patients and 872 controls using whole genome amplified DNA. To detect variants with modest effect size and discriminate among false positive findings 19 SNPs showing a trend of association in the initial screen were genotyped in a replication sample of 580 German sporadic ALS patients and 361 controls. We did not detect strong evidence of association with any of the genes investigated in the discovery sample (lowest uncorrected P-value 0.00037, lowest permutation corrected P-value 0.353). None of the suggestive associations was replicated in a second sample, further excluding variants with moderate effect size. We conclude that common variation in the investigated pathways is unlikely to have a major effect on susceptibility to sporadic ALS. The genotyping efficiency was only slightly decreased (∼1%) and genotyping quality was not affected using whole genome amplified DNA. It is reliable for large scale genotyping studies of diseases such as ALS, where DNA sample collections are limited because of low disease prevalence and short survival time. © 2007 The Author(s)
Electromagnetic form factors of the nucleon in a covariant diquark model
We present a simple covariant constituent diquark-quark model for the
nucleon. The nucleon is assumed to be composed of a scalar diquark and a quark
which interact via a quark exchange. Starting from the Bethe-Salpeter equation,
the instantaneous approximation leads to a diquark-quark Salpeter equation. In
the Mandelstam formalism, the electromagnetic form factors of the nucleon are
calculated for momentum transfers up to q^2 = - 3 \; (\mbox{GeV/c})^2. A
remarkable description of the experimental data is obtained. Especially, the
model gives nearly the right values for the proton and (negative) neutron
charge radii, and a qualitative description of the magnetic form factors.Comment: 17 pages, revtex, 8 figures in additional fil
Active Brownian Particles. From Individual to Collective Stochastic Dynamics
We review theoretical models of individual motility as well as collective
dynamics and pattern formation of active particles. We focus on simple models
of active dynamics with a particular emphasis on nonlinear and stochastic
dynamics of such self-propelled entities in the framework of statistical
mechanics. Examples of such active units in complex physico-chemical and
biological systems are chemically powered nano-rods, localized patterns in
reaction-diffusion system, motile cells or macroscopic animals. Based on the
description of individual motion of point-like active particles by stochastic
differential equations, we discuss different velocity-dependent friction
functions, the impact of various types of fluctuations and calculate
characteristic observables such as stationary velocity distributions or
diffusion coefficients. Finally, we consider not only the free and confined
individual active dynamics but also different types of interaction between
active particles. The resulting collective dynamical behavior of large
assemblies and aggregates of active units is discussed and an overview over
some recent results on spatiotemporal pattern formation in such systems is
given.Comment: 161 pages, Review, Eur Phys J Special-Topics, accepte
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