73 research outputs found
The capabilities approach and critical social policy: lessons from the majority world?
The capabilities approach (CA) most closely associated with the thinner and thicker versions of Sen and Nussbaum has the potential to provide a paradigm shift for critical social policy, encompassing but also transcending some of the limitations associated with the Marshallian social citizenship approach. The article argues, however, that it cannot simply be imported from the majority world, rather there is a need to bear in mind the critical literature that developed around it. This is generally discussed and then critically applied to case studies of CA in the developed capitalist world, particularly the Equalities Review conducted for the Equality and Human Rights Commission
Measurement of the Charged Multiplicities in b, c and Light Quark Events from Z0 Decays
Average charged multiplicities have been measured separately in , and
light quark () events from decays measured in the SLD experiment.
Impact parameters of charged tracks were used to select enriched samples of
and light quark events, and reconstructed charmed mesons were used to select
quark events. We measured the charged multiplicities:
,
, from
which we derived the differences between the total average charged
multiplicities of or quark events and light quark events: and . We compared
these measurements with those at lower center-of-mass energies and with
perturbative QCD predictions. These combined results are in agreement with the
QCD expectations and disfavor the hypothesis of flavor-independent
fragmentation.Comment: 19 pages LaTex, 4 EPS figures, to appear in Physics Letters
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 Ă 10-20), ER-negative BC (P=1.1 Ă 10-13), BRCA1-associated BC (P=7.7 Ă 10-16) and triple negative BC (P-diff=2 Ă 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 Ă 10-3) and ABHD8 (P<2 Ă 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3âČ-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk
A Robust Design Approach to Cost Estimation: Solar Energy for Marine Corps Expeditionary Operations
Annual Acquisition Research SymposiumNaval Postgraduate School Naval Postgraduate School Acquisition Research Progra
Human well-being and social structures: relating the universal and the local
There exists a contradiction between the domination of postmodernism and cultural relativism in intellectual life and the universalism and globalism dominant in the real world of institutions and politics. In this topsy-turvy world, core values and needs are relative and local, while means and policies are global and universal. This article contributes to those challenging this world-view. The first part looks at human well-being and contrasts the intellectual case for a universalist understanding of all peopleâs capabilities and the case for localism, respect for peopleâs values and knowledge, before exploring theoretical attempts to reconcile the two. The second part turns to the world of institutions and structures. It considers ideas of globalization as a universal trajectory before moving on to defend multi-level and middle-range frameworks. The article concludes by arguing for a clearer distinction between universal needs, local need satisfiers and subjective understandings, together with a comparative middle-range theory to explain contemporary success and failure in improving human well-being
Touts and the Control of Facilities in âBleedingâ Harare: A Theoretical Explanation of the Dynamics of Corruption in an African City
- âŠ