Transient changes in magnetospheric‐ionospheric currents caused by the passage of an interplanetary shock: Northward interplanetary magnetic field case

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94908/1/jgra20240.pd

Twists in U(sl(3)) and their quantizations

The solution of the Drinfeld equation corresponding to the full set of different carrier subalgebras in sl(3) are explicitly constructed. The obtained Hopf structures are studied. It is demonstrated that the presented twist deformations can be considered as limits of the corresponding quantum analogues (q-twists) defined for the q-quantized algebras.Comment: 31 pages, Latex 2e, to be published in Journ. Phys. A: Math. Ge

PREVENTION OF ONCOLOGICAL DISEASES AS THE BASIS OF INTERACTION OF ONCOLOGICAL SERVICE WITH PRIMARY LINK OF HEALTH CARE

Malignant neoplasms (MN) are the second cause of death for the population of Russia, resulted in 15.5% of all deaths in 2015. Their share in the structure of the male population mortality rate was 16.4%, female — 14.4%. Among both sexes, deaths of working age, the proportion of deaths from MN was 16.0%, among women of reproductive age — 16.3%. More than half of the working age population of deaths in Russia falls on the disease from the group of preventable death, and a third — to preventable causes, depending on the primary and secondary prevention, quality of care, along with a high prevalence of behavioral risk factors (RF), demographic characteristics, marked medical and social reasons for the high mortality rate of the MN: late uptake of the population for health care, lack of alertness in oncology healthcare professionals, patients defects in routing.The leading factor in increasing life expectancy is prevention. Today, prevention is regarded as active method of strengthening and preservation of health, and the currently existing approaches in promoting healthy life mostly only directed at the prevention of behavioral risk factors: tobacco use, poor diet, physical inactivity and harmful use of alcohol. Experts estimate the impact on them will prevent, at least 40% of the cases of MN.In Russia we have a 3-step system of health care. In general preventive health orientation is implemented on the 1st level: in the provision of primary health care. In this regard, particular attention should be paid to the implementation of measures for specific clinical examination of the adult population, which plays an important role in the early detection of both the disease and the risk factors for their development. Properly organized conduct of the clinical examination can provide a substantial, up to 30%, the contribution to the reduction of total mortality, including mortality from MN. The necessity of increasing the role of the oncology service in the organizational and methodological support of the preventive measures implemented by primary health care is performed

Independent estimation of T\u3csup\u3e*\u3c/sup\u3e2 for water and fat for improved accuracy of fat quantification

Noninvasive biomarkers of intracellular accumulation of fat within the liver (hepatic steatosis) are urgently needed for detection and quantitative grading of nonalcoholic fatty liver disease, the most common cause of chronic liver disease in the United States. Accurate quantification of fat with MRI is challenging due the presence of several confounding factors, including T z.ast;2 decay. The specific purpose of this work is to quantify the impact of Tz.ast;2decay and develop a multiexponential Tz.ast;2 correction method for improved accuracy of fat quantification, relaxing assumptions made by previous T z.ast;2 correction methods. A modified Gauss-Newton algorithm is used to estimate the Tz.ast;2 for water and fat independently. Improved quantification of fat is demonstrated, with independent estimation of Tz.ast;2 for water and fat using phantom experiments. The tradeoffs in algorithm stability and accuracy between multiexponential and single exponential techniques are discussed. © 2010 Wiley-Liss, Inc

PREDICTION BACKUP TESTICULAR FUNCTION IN PATIENTS WITH NONOBSTRUCTIVE AZOOSPERMIA

Modern authors believe that male infertility accounts for 40–50%. The most severe form of male infertility is azoospermia, which is observed in 10–15% of cases. The only method of diagnosis of azoospermia is testicular biopsy, which allows not only to differentiate the secretory and excretory forms of infertility, but also to determine the degree of impairment of spermatogenesis.Purpose. To improve the diagnosis of male infertility.Materials and methods. We have examined 26 men with non-obstructive azoospermia (according to semen). The comparison group included healthy men – 22 people. Patients underwent biopsy of the testicle, followed by morphological analysis of biopsies. Sections of testicular tissue was stained with hematoxylin and eosin, indirect immunohistochemical studies – definition of Inhibin B, a protein prolife ration and apoptosis (ki-67)Results. According to clinical and instrumental examination (ultrasound) we found no abnormalities. Patients set idiopathic form of infertility. When painting testice slices with hematoxylin and eosin, we recorded significant changes in the convoluted seminiferous tubules in patients with azoospermia: the diameter is reduced to 1.5–2 times (hypoplasia), the basement membrane with a strong fiber component (fibrosis) (p < 0,05). Expressed Inhibin tissue expression observed in Sertoli cells (“+++”) and to a lesser extent in spermatogonia ( «±»), located closer to the basal membrane convoluted seminiferous tubule. The expression level of Inhibin in germ cells - up to 5%. ki-67 protein expression was observed in the nuclei (S-phase of mitosis) spermatogonia (“++”) at stages II and III and spermatogenesis in some primary nuclei (“+”) and secondary (“+”) spermatocytes. Expression of ki-67 level in the germ cells – up to 25%.Conclusion. Determination of tissue levels of Inhibin-B can be used as a p rognostic test backup testicular function

Biomarkers of Myopic Choroidal Neovascularization in Women, Determining the Clinical Course and Response to Anti-VEGF Therapy

Aim: to identify clinical and laboratory biomarkers that determine the nature of the course of myopic choroidal neovascularization (mCNV) and the response to anti-VEGF therapy in women.Material and methods. A prospective non-randomized study was conducted in 52 patients (52 eyes) with active mCNV, treated with ranibizumab intravitreally, 0.5mg. After 12months, the suppression of CNV activity, the number of injections and the fellow eye inclusion in the pathological process were taken into account. There were 2 groups: with a favorable clinical course (n = 31, age – 33,0 ± 5,1 years, anterior-posterior axis (APA) 28,5 ± 0,3 mm) and an unfavorable clinical course (n = 21, age – 34,0 ± 4,1 years, APA – 29,01 ± 0,1 mm). Structural retinal changes, choroid thickness, retinal blood flow, and heart rate were evaluated using OCT and OCTA protocols (Optovue XR Avanti, USA). Studies were conducted before the start of therapy and then one time per month. The concentration of sex and pituitary hormones (ELISA analyzer “Immunohem-2100”), lipoprotein A, Apo B/Apo A (Accent 200 Cormay, Poland), coagulogram data (Helena C-2, UK), and the concentration of highly sensitive C-reactive protein in blood serum before the start of antiangiogenic therapy were studied once.Results. In the first group, 1.4 ± 0.7 ranibizumab injections were administered to suppress the CNV activity. In the opposite group – 3.5 ± 2.1 injections, in 73.7 % of cases, relapses were diagnosed, in 3 cases – primary CNV in the fellow eye. Clinical and laboratory biomarkers of the unfavorable clinical course of mCNV were identified: extreme choroidal thinning, highly organized membranes of a large area, dome-shaped deformation of the posterior pole, excess of the reference values of lipoprotein A, fibrinogen and highly sensitive C-reactive protein by two or more times, an imbalance of sex and pituitary hormones (excess of the reference values of prolactin, follicle stimulating hormone, cortisol, progesterone concentration decrease), a predominant change in the menstrual-ovarian cycle according to the type of amenorrhea and opsomenorrhea.Conclusion. Myopic CNV biomarkers in women allow predicting the response to anti-VEGF therapy, the formation of relapses and the inclusion of the fellow eye in the pathological process

Nuclear dependence of the transverse single-spin asymmetry in the production of charged hadrons at forward rapidity in polarized p+pp+p, p+p+Al, and p+p+Au collisions at sNN=200\sqrt{s_{_{NN}}}=200 GeV

We report on the nuclear dependence of transverse single-spin asymmetries (TSSAs) in the production of positively-charged hadrons in polarized $p^{\uparrow}+p$, $p^{\uparrow}+$Al and $p^{\uparrow}+$Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV. The measurements have been performed at forward rapidity ($1.4<\eta<2.4$) over the range of $1.8<p_{T}<7.0$ GeV$/c$ and $0.1<x_{F}<0.2$. We observed a positive asymmetry $A_{N}$ for positively-charged hadrons in \polpp collisions, and a significantly reduced asymmetry in $p^{\uparrow}$+$A$ collisions. These results reveal a nuclear dependence of charged hadron $A_N$ in a regime where perturbative techniques are relevant. These results provide new opportunities to use \polpA collisions as a tool to investigate the rich phenomena behind TSSAs in hadronic collisions and to use TSSA as a new handle in studying small-system collisions.Comment: 303 authors from 66 institutions, 9 pages, 2 figures, 1 table. v1 is version accepted for publication in Physical Review Letters. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm